2018
DOI: 10.1186/s13104-018-3145-8
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Cytotoxic T lymphocytes from cattle sharing the same MHC class I haplotype and immunized with live Theileria parva sporozoites differ in antigenic specificity

Abstract: ObjectivesThe objective of this study was to assess whether cytotoxic T cells (CTL) generated by the live vaccine, known as “ITM Muguga cocktail”, which is used for the cattle disease East Cost fever (ECF) in Sub-Saharan Africa, showed a broad reactivity against many different strains of the causative parasite Theileria parva. We also assessed whether immune responses were similar in cattle expressing the same MHC class I haplotypes.ResultsThe antigenic specificity of CTL from MHC class I-matched cattle vaccin… Show more

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Cited by 4 publications
(6 citation statements)
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“…Thus, it could be relevant to test an improved alternative vaccine in lowlands and midlands areas that include local parasite stocks to provide broad protection. In order to initiate a vaccination trial, the MHC class I diversity in cattle from the Great Lakes region could be assessed because of the differential immune responses between cattle of different MHC class I haplotypes [64].…”
Section: Discussionmentioning
confidence: 99%
“…Thus, it could be relevant to test an improved alternative vaccine in lowlands and midlands areas that include local parasite stocks to provide broad protection. In order to initiate a vaccination trial, the MHC class I diversity in cattle from the Great Lakes region could be assessed because of the differential immune responses between cattle of different MHC class I haplotypes [64].…”
Section: Discussionmentioning
confidence: 99%
“…The difference in response between the CTL lines toward the different Tp9 alanine mutant peptides and field variants is not an unusual phenomenon. A previous study from our group had observed that CTLs from cattle expressing the same BoLA class I molecules react differently toward the same T. parva strain ( 46 ). These differences can be caused by several factors, including differences in TCR repertoire, single-nucleotide polymorphism in innate or adaptive immunity genes, or difference in epigenetic factors.…”
Section: Discussionmentioning
confidence: 97%
“…This indicated that there are epitopes in T. parva leading to CTL cross-reaction. Nonetheless, recent studies have shown that differential specificities toward CTL Ags can emerge from immunization with the Muguga cocktail ITM vaccine, even in identical MHC background ( 46 ), and breakthroughs have been observed in the field with cattle immunized by ITM in a buffalo-endemic area ( 47 ). Moreover, partial cross-reaction of a Tp2 CTL line toward certain natural variants of the Tp2 49–59 T. parva CTL epitope has been demonstrated in vitro ( 48 ).…”
Section: Discussionmentioning
confidence: 99%
“…The majority (seven of eight) of studies reported the Muguga cocktail to be efficacious, with statements such as "very high degree of vaccine efficacy" [68], "good margin of vaccine efficacy" [70], and "efficacy is exemplified by the successful immunisation of some 400,000 cattle in Uganda and Tanzania in recent years" [72]. A single study by Steinaa et al [73] reported no substantive difference in protection with the Muguga cocktail in comparison to a single T. parva strain (Muguga), suggesting limited antigenic diversity in the cocktail. Although not stated explicitly, efficacy was implied.…”
Section: Discussionmentioning
confidence: 99%
“…Steinaa et al [73] compared the protection given with a single T. parva strain (Muguga) to immunizing with the trivalent Muguga cocktail, and found no substantive difference in protection, with no broader a CTL response when using the cocktail, suggesting limited antigenic diversity in the cocktail.…”
Section: Efficacy As a Statement (Qualitative)mentioning
confidence: 99%