Cytotoxic Triterpenoids from the Leaves of <i>Microtropis fokienensis</i>

Chen, I-Hsiao; Chang, Fang‐Rong; Wu, Chueh-Hung; Chen, Shuli; Hsieh, Pei‐Wen; Yen, Hsin-Fu; Du, Ying-Chi; Wu, Yang‐Chang

doi:10.1021/np060369n

Cited by 29 publications

(31 citation statements)

References 23 publications

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“…On the other hand, the singlet peak at δ 5. [20]. This was further supported by the medium intensity diagnostic EI-MS fragmentation peaks which appeared at m/z 289 and 248.…”

Section: Resultsmentioning

confidence: 60%

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Terpenoids of Boswellia neglecta oleo-gum resin

Manguro¹,

Wagai²,

Onyango³

2016

Bull. Chem. Soc. Eth.

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“…On the other hand, the singlet peak at δ 5. [20]. This was further supported by the medium intensity diagnostic EI-MS fragmentation peaks which appeared at m/z 289 and 248.…”

Section: Resultsmentioning

confidence: 60%

“…Compounds 1, 2, 11, 12 and 13 are reported from B. neglecta gum resin for the first time. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] showed no spot and solvent recovered. Sub-fraction II (fractions 30-60) produced colorless oil and was kept under freezing conditions a waiting GC-MS analysis.…”

Section: Introductionmentioning

confidence: 99%

Terpenoids of Boswellia neglecta oleo-gum resin

Manguro¹,

Wagai²,

Onyango³

2016

Bull. Chem. Soc. Eth.

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“…Compound 55 was found to be the strongest cytotoxic activity against HepG2 and Hep3B cancer cell lines, with IC 50 values of 3.8 and 4.5 lg/ml, respectively. Compound 56 also exhibited cytotoxic activity against the HepG2 cell line, with IC 50 values of 4.6 lg/ml (Chen et al 2006).…”

Section: Introductionmentioning

confidence: 98%

Anti-hepatocellular carcinoma activity and mechanism of chemopreventive compounds: ursolic acid derivatives

Huang

Chen

Ren

et al. 2016

Pharmaceutical Biology

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Context: Hepatocellular carcinoma (HCC) is a common cancer around the world, with high mortality rate. Currently, there is no effective drug for the therapy of HCC. Ursolic acid (UA) is a natural product which exists in various medicinal herbs and fruits, exhibiting multiple biological effects such as its outstanding anticancer and hepatoprotective activity, which has drawn many pharmacists' attention. Objective: This paper summarizes the current status of the hepatoprotective activity of UA analogues and explains the related mechanism, providing a clear direction for the development of novel anti-HCC drugs. Methods: All of the data resources were derived from PubMed. By comparing the IC 50 values and analyzing the structure-activity relationships, we listed compounds with good pharmacological activity from the relevant literature, and summarized their anti-HCC mechanism. Results: From the database, 58 new UA derivatives possessing wonderful anticancer and hepatoprotective effects were listed, and the relevant anti-HCC mechanism were discussed. Conclusion: UA's anti-HCC effect is the result of combined action of many mechanisms. These 58 new UA derivatives, particularly compounds 45 and 53, can be used as potential drugs for the treatment of liver cancer. ARTICLE HISTORY

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“…The chemical constituents of the Microtropis species in Taiwan include sesquiterpenoids, diterpenoids, and triterpenoids [2][3][4][5]. Pentacyclic triterpenoids are the dominant constituents within the genus Microtropis and have a basic framework that is similar to that of oleanane, ursane or lupane.…”

Section: Introductionmentioning

confidence: 99%

“…Pentacyclic triterpenoids are the dominant constituents within the genus Microtropis and have a basic framework that is similar to that of oleanane, ursane or lupane. Previously, we reported various cytotoxic triterpenoids that worked against cancer cell lines isolated from M. fokienensis and M. japonica [4][5][6]. There are no prior reports on the anti-inflammatory effects of metabolites from the genus Microtropis.…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory Triterpenoids from the Stems of Microtropis Fokienensis

Chen

Du²,

Hwang

et al. 2014

Molecules

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Three new ursane-and four new oleanane-type triterpenoids 1-7 were isolated, along with six known compounds 8-13, from the methanolic extract of Microtropis fokienensis. All structures were elucidated by mass and NMR spectroscopic methods. The isolates 4-10 and known compounds 14-17 that were previously isolated from this material were evaluated for anti-inflammatory activity based on effects against superoxide anion generation and elastase release by neutrophils in response to fMLP/CB. 11α,30-Dihydroxy-2,3-seco-olean-12-en-2,3-dioic anhydride (7) was the first triterpene anhydride from the genus of Microtropis to have the ring A expanded to a seven-membered ring; it showed significant anti-inflammatory activity against superoxide anion generation and elastase release. Unexpectedly, 30-hydroxy-2,3-seco-lup-20(29)-ene-2,3-dioic acid (17) showed the best effect against superoxide anion generation and elastase release with IC 50 values of 0.06 ± 0.01 and 1.03 ± 0.35 µg/mL, respectively. Compound 17 had a dioic acid function, and compound 7 had an anhydride function modification in ring A; both showed promising activity in the target assays.

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Cytotoxic Triterpenoids from the Leaves of Microtropis fokienensis

Cited by 29 publications

References 23 publications

Terpenoids of Boswellia neglecta oleo-gum resin

Terpenoids of Boswellia neglecta oleo-gum resin

Anti-hepatocellular carcinoma activity and mechanism of chemopreventive compounds: ursolic acid derivatives

Anti-Inflammatory Triterpenoids from the Stems of Microtropis Fokienensis

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