Cytotoxic withanolides from the aerial parts of Tubocapsicum anomalum

Osteosarcoma cell proliferation suppression via SHP-2-mediated inactivation of the JAK/STAT3 pathway by tubocapsenolide A

“…Therefore, agents that can inhibit STAT3 signal can be used in the treatment and prevention of cancer. TA is identified as a withanolide exhibiting cytotoxicity against a variety of human tumor cell lines [19] . However, the molecular mechanism and inhibitory effect of TA on JAK/STAT3 signaling remain largely unknown.…”

“…However, the specific mechanism underlying the suppressive effects of these agents on STAT3 remains largely unexplored. TA, a withanolide isolated from Tubocapsicum anomalum , has been shown to possess potent anti-proliferative activity in several cancer cell lines [18] , [19] . However, its in vitro and in vitro effects on osteosarcoma remain largely unknown.…”

Recent Advances in the Chemistry and Therapeutic Evaluation of Naturally Occurring and Synthetic Withanolides

“…Ten new withanolides were isolated from Tubocapsicum anomalum and were screened for anti-proliferative activities against four human tumor cell lines (HCT-116, HepG2, MCF-7, and A375) using cisplatin as a positive control [ 101 ]. Compounds 95 – 99 ( Figure 12 ) were the most potent among all the tested withanolides against all the tested cell lines, with IC 50 values ranging between 0.24–8.71 μM.…”

The complete chloroplast genome sequence of wild Japanese pepper Tubocapsicum anomalum Makino (Solanaceae)

“…Tubocapsicum anomalum Makino 1908 (Solanaceae) is a medicinal herb with small yellow flowers and red juicy berries (Arcy et al 2001). It is distributed in East Asia and Southeast Asia (Wang et al 2018). Previous studies have indicated that Tubocapsicum anomalum may be developed as a novel class of chemopreventive drugs for the treatment of human cancers (Chang et al 2007;Khan et al 2012).…”

“…It is distributed in East Asia and Southeast Asia (Wang et al. 2018 ). Previous studies have indicated that Tubocapsicum anomalum may be developed as a novel class of chemopreventive drugs for the treatment of human cancers (Chang et al.…”