Cytotoxicent-Kaurane Diterpenoids fromIsodon eriocalyx

Abstract

Five new ent-kaurane diterpenoids, epi-maoecrystal N (1), eriocalyxin G (2), maoecrystal W (3), maoecrystal X (4), and maoecrystal Y (5), along with 22 known ones, were isolated from Isodon eriocalyx (Dunn.) Hara., and their structures were determined by spectroscopic methods. All diterpenoids, except for 3 and 13, were evaluated for inhibition of the K562, T-24, Me180, QGY-7701, and BIU87 cell lines (Table 2).

Maoecrystal Z, a Cytotoxic Diterpene from Isodon eriocalyx with a Unique Skeleton

“…Furthermore, it has been proven to be a rich source of novel ent -kauranoids with interesting structural features of daedal oxygenation and cleavage patterns. So far, more than 50 diterpenes including over 30 new ones have been isolated and identified from this herb in recent years. , Our further investigation on the bioactive ingredients of this herb has led to the isolation of a novel diterpene ( 1 ) with an unprecedented backbone. Its structure was established according to its NMR and MS spectral data, and confirmed by X-ray diffraction, to be 6β-hydroxy-11α-acetoxy-6,7:8,15-di -seco -7,20- olide -6,8-cyclo- ent -kaur-16-en-15-aldehyde.…”

Cytotoxic ent-kaurane diterpenoids from Isodon sinuolata

“…Phytochemical study of the ethyl acetate extract of I. sinuolata led to isolation of five new ent-kaurane diterpenoids, sinuolatins A-E (1-5), together with 17 known substances, including maoecrystal A (6) (Hou et al, 2000), maoecrystal G (7) (Xiang et al, 2004), longikaurin E (8) (Fujita et al, 1981), lasiodonin (9) , nodosin (10) , oreskaurin C (11) (Xiang et al, 2004), rubescensin Q (12) (Han et al, 2005), enmenin (13) (Shen et al, 2005), trichorabdal A (14) (Node et al, 1982), adenolin A (15) (Zhang et al, 1992), oreskaurin B (16) (Xiang et al, 2004), isodonal (17) , adenolin B (18) (Zhang et al, 1992), wikstroemioidin B (19) (Wu et al, 1993), wikstroemioidin C (20) (Wu et al, 1993), macrocalyxin J (21) (Shi et al, 2007), and effusanin E (22) (Fujita et al, 1980b) (Fig. 1).…”

Bioactive Natural Spirolactone-Type 6,7-seco-ent-Kaurane Diterpenoids and Synthetic Derivatives

“…Three new, together with six known, spirolactone-type diterpenoids were isolated by Shen and coworkers from I. eriocalyx (Dunn.) Hara in 2005 [ 74 ]. The cytotoxicity against T-24, K562, Me180 (human cervical epithelial cancer), QGY-7701 (human hepatoma), and BIU87 cell lines.…”