Cytotoxicity and antiviral activity of transition-metal salicylato complexes and crystal structure of Bis(diisopropylsalicylato)(1,10-phenanthroline)copper(II)

Ranford, John D.; Sadler, Peter J.; Tocher, Derek A.

doi:10.1039/dt9930003393

Cited by 228 publications

(135 citation statements)

References 19 publications

Supporting

Mentioning

130

Contrasting

Order By: Relevance

“…The Cu--N(amine) [average 2.003 (5).4,1 and the Cu--N(pyridine) [average 2.051 (6)A] bond lengths in the equatorial plane agree very well with those generally found in square-planar (Tamburini, Vigato & Casellato, 1989), square-pyramidal (Rajendran, Viswanathan, Palaniandavar & Lakshminarayanan, 1992) and distorted octahedral (Ranford, Sadler & Tocher, 1993) complexes. In addition, the Cun ion makes two axial Cu---O contacts to the O atoms of the two phenolic groups of the HBPA ligands.…”

Section: Bis[2-(2-pyridylmethylaminomethyl)-phenol]copper(ii)supporting

confidence: 73%

Bis[2-(2-pyridylmethylaminomethyl)phenol]copper(II) Diacetate Trihydrate [Cu(HBPA)2](CH3COO)2.3H2O

Neves¹,

Vencato²,

Verani³

1996

Acta Crystallogr C

View full text Add to dashboard Cite

Section: Bis[2-(2-pyridylmethylaminomethyl)-phenol]copper(ii)supporting

confidence: 73%

Bis[2-(2-pyridylmethylaminomethyl)phenol]copper(II) Diacetate Trihydrate [Cu(HBPA)2](CH3COO)2.3H2O

Neves¹,

Vencato²,

Verani³

1996

Acta Crystallogr C

View full text Add to dashboard Cite

“…Moreover, Ranford & al. [6] studied transition-metal salicylate complexes with (1,10-phenanthroline). So, we have been interested to synthesize nickel(II) complexes with salicylate and metformin instead of (1,10-phenanthroline).…”

Section: Discussionmentioning

confidence: 99%

Crystal structure of bis(N,N-dimethylbiguanide)nickel(II) salicylate, C22H32N10NiO6

Lemoine

Tomas

Viossat

et al. 1999

Zeitschrift Für Kristallographie - New Crystal Structures

View full text Add to dashboard Cite

Source of materialThis compound was obtained in methanolic medium by reaction of metformin hydrochloride (2·10~3 mol) and nickel salicylate (10~3 mol). The reaction mixture was stirred during 30 minutes. Orange-yellow parallelepipedic shaped crystals were obtained by slow evaporation of this solution under ambient air pressure. DiscussionBiguanide (imidodicarbonimidiamide) and its N-substituted derivatives are interesting ligands which form hightly coloured complexes with many transition metals [1]. On the other hand, some biguanides such as phenformin (phenylbiguanide), buformin (butylbiguanide) and metformin (iV,/V-dimethylbiguanide) were introduced as glucose-lowering agents for the treatment of non-insulin-dependent diabetes mellitus [2], Metformin which differs from other ligands in several important respects, is now accepted as the standard biguanide ligand. We have described ligand structural properties of metal complexes with metformin and Cu(II), Ni(II), Co(II) ions [3][4][5]. Moreover, Ranford & al. [6] studied transition-metal salicylate complexes with (1,10-phenanthroline). So, we have been interested to synthesize nickel(II) complexes with salicylate and metformin instead of (1,10-phenanthroline).

show abstract

“…Sadler and diimines as coligands exhibit cytotoxic and antiviral activities. Burstyn and coworker have found that copper(II) complexes of macrocyclic triamines promote the hydrolytic cleavage of plasmid DNA [42] . Chakravarty and his coworkers [43] have reported several Cu(II) complexes that could show photoinduced DNA and protein cleavage activity for their potential application as photodynamic therapy and anti-metastasis agents.…”

Section: Anticancer Activitymentioning

confidence: 99%

Synthesis, characterization and DNA binding of copper(II) complexes with mixed ligands of 1, 10-phenanthroline / 2-2’ bipyridyl, L-methionine and ethylamine: Studies on antimicrobial and anti-cancer activities

Ezhilarasan¹,

Krishnan²,

Arumugham³

2017

Int. J. Curr. Res. Chem. Pharm. Sci

View full text Add to dashboard Cite

Ternary copper(II) complexes [Cu(phen)(L-met)EA)] 1 & [Cu(Bpy)(L-met)EA] 2 ( phen = 1,10-phenanthroline Bpy = bipyridyl, LMethionine and EA= Ethylamine), have been synthesized and characterized by CHN analysis, molar conductance, electronic absorption, IR and EPR spectral studies. They have been tested for their in vitro DNA binding activities by the spectroscopic methods such as UV-Visible, Cyclic volumetric and viscosity measurement. Further, complexes 1 and 2 displayed significant cytotoxicity when examined in-vitro on a panel of cancerous cell line -human liver cancer cell line -HepG-2 cells (IC50= 40.82 and 29.74 μg/ml). Further complexes 1 & 2 were tested for their antimicrobial activities and it was found to have good antimicrobial activities.

show abstract

Cytotoxicity and antiviral activity of transition-metal salicylato complexes and crystal structure of Bis(diisopropylsalicylato)(1,10-phenanthroline)copper(II)

Cited by 228 publications

References 19 publications

Bis[2-(2-pyridylmethylaminomethyl)phenol]copper(II) Diacetate Trihydrate [Cu(HBPA)2](CH3COO)2.3H2O

Bis[2-(2-pyridylmethylaminomethyl)phenol]copper(II) Diacetate Trihydrate [Cu(HBPA)2](CH3COO)2.3H2O

Crystal structure of bis(N,N-dimethylbiguanide)nickel(II) salicylate, C22H32N10NiO6

Synthesis, characterization and DNA binding of copper(II) complexes with mixed ligands of 1, 10-phenanthroline / 2-2’ bipyridyl, L-methionine and ethylamine: Studies on antimicrobial and anti-cancer activities

Contact Info

Product

Resources

About