Cytotoxicity and biocompatibility evaluation of a poly(magnesium acrylate) hydrogel synthesized for drug delivery

Cheddadi, Maha; López-Cabarcos, Enrique; Slowing, Karla; Barcia, Emilia; Fernández-Carballido, Ana

doi:10.1016/j.ijpharm.2011.04.042

Cited by 30 publications

(16 citation statements)

References 26 publications

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“…The in vitro cytotoxicity of the gels was evaluated by using a direct contact method according to ISO 10933 . The hydrogel samples were cut into 100 µm thickness disks with vibroslicer (752M Vibroslice, Campden Instruments, UK).…”

Section: Methodsmentioning

confidence: 99%

Poly (Ethylene Glycol)‐Based Hydrogels as Self‐Inflating Tissue Expanders with Tunable Mechanical and Swelling Properties

Jamadi

Shokrollahi

Houshmand

et al. 2017

Macromolecular Bioscience

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Tissue expansion is used by plastic/reconstructive surgeons to grow additional skin/tissue for replacing or repairing lost or damaged soft tissues. Recently, hydrogels have been widely used for tissue expansion applications. Herein, a self-inflating tissue expander blend composition from three different molecular weights (2, 6, and 10 kDa) of poly (ethylene glycol) diacrylate (PEGDA) hydrogel with tunable mechanical and swelling properties is presented. The in vitro results demonstrate that, of the eight studied compositions, P6 (PEGDA 6 kDa:10 kDa (50:50)) and P8 (PEGDA 6 kDa:10 kDa (35:65)) formulations provide a balance of mechanical property and swelling capability suitable for tissue expansion. Furthermore, these expanders can be compressed up to 60% of their original height and can be loaded and unloaded cyclically at least ten times with no permanent deformation. The in vivo results indicate that these two engineered blend compositions are capable to generate a swelling pressure sufficient to dilate the surrounding tissue while retaining their original shape. The histological analyses reveal the formation of fibrous capsule at the interface between the implant and the subcutaneous tissue with no signs of inflammation. Ultimately, controlling the PEGDA chain length shows potential for the development of self-inflating tissue expanders with tunable mechanical and swelling properties.

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Section: Methodsmentioning

confidence: 99%

Poly (Ethylene Glycol)‐Based Hydrogels as Self‐Inflating Tissue Expanders with Tunable Mechanical and Swelling Properties

Jamadi

Shokrollahi

Houshmand

et al. 2017

Macromolecular Bioscience

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show abstract

“…In addition, cytotoxicity studies in human cells were carried out. For this purpose, we used the MTT ((3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay and a cytofluorometric analysis to determine their impact on human neutrophil apoptosis and survival [24][25][26]. All of them were devoid of any toxic effect in these in vitro assays.…”

Section: Introductionmentioning

confidence: 99%

2,3,9- and 2,3,11-Trisubstituted tetrahydroprotoberberines as D2 dopaminergic ligands

Párraga

Cabedo

Andújar

et al. 2013

European Journal of Medicinal Chemistry

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“…The increased viscosity may be the reason for the slight toxicity demonstrated at these polymer concentrations, as also suggested by others, studying the cytotoxicity of hydrogels. 52 Indeed, we have seen in many cases that dispersions of large multilamellar liposomes demonstrate significant toxicity toward various cell types, whereas small unilamellar liposomes incubated at the same lipidic concentrations do not. This is explained by the hypothesis that the toxicity demonstrated (in the case of the MLV liposomes) is not directly caused by the lipid components of the liposomes but by their size and perhaps the fact that dispersions of large liposomes have higher viscosity compared with dispersions of nanosized ones (of identical composition and lipid concentration).…”

Section: ' Results and Discussionmentioning

confidence: 98%

pH-Responsive Hydrogel/Liposome Soft Nanocomposites For Tuning Drug Release

et al. 2011

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A novel liposome/hydrogel soft nanocomposite was explored as a controlled drug delivery system. A P2VP-PAA-PnBMA biocompatible, pH-responsive triblock terpolymer was used as an injectable gelator, entrapping PC/Chol liposomes loaded with calcein as hydrophilic model drug. The composite hydrogel was formed in vitro through a pH-induced sol-gel transition by dialysis against buffer under physiological conditions and at polymer concentration as low as 1 wt %. Excellent control of the calcein release was achieved just by adjusting the gelator concentration; that is, from 1 to 1.5 wt %, the drug release period was significantly prolonged from 14 to 32 days.

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Cytotoxicity and biocompatibility evaluation of a poly(magnesium acrylate) hydrogel synthesized for drug delivery

Cited by 30 publications

References 26 publications

Poly (Ethylene Glycol)‐Based Hydrogels as Self‐Inflating Tissue Expanders with Tunable Mechanical and Swelling Properties

Poly (Ethylene Glycol)‐Based Hydrogels as Self‐Inflating Tissue Expanders with Tunable Mechanical and Swelling Properties

2,3,9- and 2,3,11-Trisubstituted tetrahydroprotoberberines as D2 dopaminergic ligands

pH-Responsive Hydrogel/Liposome Soft Nanocomposites For Tuning Drug Release

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