Cytotoxicity and cellular uptake of ZnS:Mn nanocrystals biofunctionalized with chitosan and aminoacids

Augustine, M. Sajimol; Anas, Abdulaziz; Das, Ani V.; Sreekanth, Sreekumaran; Jayalekshmi, S.

doi:10.1016/j.saa.2014.08.147

Cited by 10 publications

(2 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…ZnS or ZnS-capped chitosan nanoparticles were prepared by several methods, e.g., γ-radiation [20], colloidal synthesis [21], or co-precipitation [22]. The wet mechanochemical approach was also successfully applied for the preparation of nanoparticles covered by biocompatible material [11, 13, 16].…”

Section: Introductionmentioning

confidence: 99%

Mechanochemistry of Chitosan-Coated Zinc Sulfide (ZnS) Nanocrystals for Bio-imaging Applications

et al. 2017

View full text Add to dashboard Cite

The ZnS nanocrystals were prepared in chitosan solution (0.1 wt.%) using a wet ultra-fine milling. The obtained suspension was stable and reached high value of zeta potential (+57 mV). The changes in FTIR spectrum confirmed the successful surface coating of ZnS nanoparticles by chitosan. The prepared ZnS nanocrystals possessed interesting optical properties verified in vitro. Four cancer cells were selected (CaCo-2, HCT116, HeLa, and MCF-7), and after their treatment with the nanosuspension, the distribution of ZnS in the cells was studied using a fluorescence microscope. The particles were clearly seen; they passed through the cell membrane and accumulated in cytosol. The biological activity of the cells was not influenced by nanoparticles, they did not cause cell death, and only the granularity of cells was increased as a consequence of cellular uptake. These results confirm the potential of ZnS nanocrystals using in bio-imaging applications.

show abstract

Section: Introductionmentioning

confidence: 99%

Mechanochemistry of Chitosan-Coated Zinc Sulfide (ZnS) Nanocrystals for Bio-imaging Applications

et al. 2017

View full text Add to dashboard Cite

show abstract

“…In this regard, there have been several papers published regarding the attempt to synthesize water-soluble semiconductor nanocrystals by the modification of their surfaces with polar organic molecules [ 15 ]. Among these, thioglycolic acid [ 16 , 17 ] and conventional amino acids [ 18 , 19 ] were found to be effective capping agents in the synthesis of water-soluble and non-toxic semiconductor nanocrystals. However, the ligand-dependent surface properties of water-dispersible nanocrystals are not yet fully understood.…”

Section: Introductionmentioning

confidence: 99%

Application of L-Aspartic Acid-Capped ZnS:Mn Colloidal Nanocrystals as a Photosensor for the Detection of Copper (II) Ions in Aqueous Solution

Heo

Hwang

2016

Nanomaterials

View full text Add to dashboard Cite

Water-dispersible ZnS:Mn nanocrystals (NCs) were synthesized by capping the surface with polar L-aspartic acid (Asp) molecules. The obtained ZnS:Mn-Asp NC product was optically and physically characterized using the corresponding spectroscopic methods. The ultra violet-visible (UV-VIS) absorption spectrum and photoluminescence (PL) emission spectrum of the NCs showed broad peaks at 320 and 590 nm, respectively. The average particle size measured from the obtained high resolution-transmission electron microscopy (HR-TEM) image was 5.25 nm, which was also in accordance with the Debye-Scherrer calculations using the X-ray diffraction (XRD) data. Moreover, the surface charge and degree of aggregation of the ZnS:Mn-Asp NCs were determined by electrophoretic and hydrodynamic light scattering methods, respectively. These results indicated the formation of agglomerates in water with an average size of 19.8 nm, and a negative surface charge (−4.58 mV) in water at ambient temperature. The negatively-charged NCs were applied as a photosensor for the detection of specific cations in aqueous solution. Accordingly, the ZnS:Mn-Asp NCs showed an exclusive luminescence quenching upon addition of copper (II) cations. The kinetic mechanism study on the luminescence quenching of the NCs by the addition of the Cu2+ ions proposed an energy transfer through the ionic binding between the two oppositely-charged ZnS:Mn-Asp NCs and Cu2+ ions.

show abstract

Biomolecules in Metal and Semiconductor Nanoparticle Growth

Baumann

Muhammed

Blanch

et al. 2015

Israel Journal of Chemistry

View full text Add to dashboard Cite

Exerting control over the size, morphology, and complexity of metal and semiconductor nanoparticles and nanostructures is a requisite for exploring novel phenomena, and the potential applications of these nanomaterials. Bottom‐up colloidal chemistry syntheses can benefit from using biomolecules as active elements to influence the formation of inorganic nanoparticles. In this review, we will discuss how three main biomolecule types, (namely DNA; amino acids, peptides, and proteins; and enzymes), can affect the growth of metal and semiconductor nanoparticles. We will present and discuss the templating and non‐templating roles of those biomolecules, featuring key aspects and prospects of biomolecule‐assisted metal and semiconductor nanoparticle growth.

show abstract

Cytotoxicity and cellular uptake of ZnS:Mn nanocrystals biofunctionalized with chitosan and aminoacids

Cited by 10 publications

References 54 publications

Mechanochemistry of Chitosan-Coated Zinc Sulfide (ZnS) Nanocrystals for Bio-imaging Applications

Mechanochemistry of Chitosan-Coated Zinc Sulfide (ZnS) Nanocrystals for Bio-imaging Applications

Application of L-Aspartic Acid-Capped ZnS:Mn Colloidal Nanocrystals as a Photosensor for the Detection of Copper (II) Ions in Aqueous Solution

Biomolecules in Metal and Semiconductor Nanoparticle Growth

Contact Info

Product

Resources

About