Cytotoxicity and degradation product identification of thermally treated ceftiofur

Zhang, Hong; Lu, Shiying; Ren, Hong-Lin; Zhao, Ke; Li, Yansong; Guan, Yuting; Li, Hanxiao; Hu, Pan; Liu, Zengshan

doi:10.1039/c9ra10289b

Cited by 7 publications

(2 citation statements)

References 63 publications

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“…Penicillins and cephalosporins are jointly the second most popular antibacterial drugs in China since 2013 [7]. Ceftiofur sodium (CEF), a third-generation animal-specifc cephalosporin antibiotic, is widely used in clinical practice to control animal diseases and is one of the most commonly used antibiotics in animal husbandry to control infections and improve animal production [8][9][10][11][12][13]. Te widespread use of CEF induces the growth of drugresistant microorganisms due to its unique chemical structure [10].…”

Section: Introductionmentioning

confidence: 99%

Rapid and Efficient Degradation of Ceftiofur Sodium by 5,6-Dimethylbenzimidazole-Modified ZIF(Fe/Co)x@CNF Nanocomposites

Wang

et al. 2023

Journal of Chemistry

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The exploration of transforming various metals as metal sources into metal organic frameworks (MOFs) has attracted considerable attention in recent years. This study used triethylamine and 5,6-dimethylbenzimidazole (DMBIM) to modify the iron-doped cobalt zeolite imidazole framework on carbon fiber structure. The results showed that the ZIF(Fe/Co)1.25@CNF exhibited high CEF removal efficiency that over 97% of ceftiofur sodium (CEF) was removed within 10 min, which was significantly higher than that of the common ZIF-67 materials. Compared with other ZIF-67 composites, ZIF(Fe/Co)x@CNF has a larger specific surface area, resulting in a larger contact area and more active sites during the reaction. After the introduction of DMBIM, the ZIF(Fe/Co)1.25@CNF not only easily separated from the solution but also enhanced the hydrophobicity, which provided higher catalytic stability and catalytic performance. In addition, the effects of different catalyst ratios, pollutant concentrations, solution pH, and different radicals (•OH, SO4•−, 1O2) on the activation of peroxymonosulfate (PMS) were investigated. The mechanism of degradation was elucidated by electron paramagnetic resonance experiments. This study provides a new perspective for the preparation of high-performance MOF catalysts with excellent catalytic performance and may facilitate the application of MOF materials in more practical situations.

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Section: Introductionmentioning

confidence: 99%

Rapid and Efficient Degradation of Ceftiofur Sodium by 5,6-Dimethylbenzimidazole-Modified ZIF(Fe/Co)x@CNF Nanocomposites

Wang

et al. 2023

Journal of Chemistry

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“…Moreover, with the growing demand for animal proteins, antibiotic residues in food and contamination of animal products with antibiotics has become a threat to public health. Hence, there is an urgent need to find novel therapeutic options and/or reduce the usage of antibiotics for treating bacterial infections in animals [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Enhancing Drug Efficacy against Mastitis Pathogens—An In Vitro Pilot Study in Staphylococcus aureus and Staphylococcus epidermidis

Rajamanickam

Yang

Babu

et al. 2020

Animals

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Background: Bovine mastitis is one of the major infectious diseases in dairy cattle, resulting in large economic loss due to decreased milk production and increased production cost to the dairy industry. Antibiotics are commonly used to prevent/treat bovine mastitis infections. However, increased antibiotic resistance and consumers’ concern regarding antibiotic overuse make it prudent and urgent to develop novel therapeutic protocols for this disease. Materials and methods: Potential druggable targets were found in 20 mastitis-causing pathogens and conserved and unique targets were identified. Bacterial strains Staphylococcus aureus (ATCC 29213, and two clinical isolates CI 1 and CI 2) and Staphylococcus epidermidis (ATCC 12228, and two clinical isolates CI 1 and CI 2) were used in the present study for validation of an effective drug combination. Results: In the current study, we identified the common and the unique druggable targets for twenty mastitis-causing pathogens using an integrative approach. Furthermore, we showed that phosphorylcholine, a drug for a unique target gamma-hemolysin component B in Staphylococcus aureus, and ceftiofur, the mostly used veterinary antibiotic that is FDA approved for treating mastitis infections, exhibit a synergistic effect against S. aureus and a strong additive effect against Staphylococcus epidermidis in vitro. Conclusion: Based on the data generated in this study, we propose that combination therapy with drugs that work synergistically against conserved and unique targets can help increase efficacy and lower the usage of antibiotics for treating bacterial infections. However, these data need further validations in animal models of infection.

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Sonocatalytic degrading antibiotics over activated carbon in cow milk

Liu,

Wu,

Lee

et al. 2024

Food Chemistry

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Cytotoxicity and degradation product identification of thermally treated ceftiofur

Abstract: Ceftiofur (CEF) is a cephalosporin antibiotic and is a commonly used drug in animal food production. This study investigated the cytotoxicity of thermally treated CEF.

Cited by 7 publications

References 63 publications

Rapid and Efficient Degradation of Ceftiofur Sodium by 5,6-Dimethylbenzimidazole-Modified ZIF(Fe/Co)x@CNF Nanocomposites

Rapid and Efficient Degradation of Ceftiofur Sodium by 5,6-Dimethylbenzimidazole-Modified ZIF(Fe/Co)x@CNF Nanocomposites

Enhancing Drug Efficacy against Mastitis Pathogens—An In Vitro Pilot Study in Staphylococcus aureus and Staphylococcus epidermidis

Sonocatalytic degrading antibiotics over activated carbon in cow milk

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