Cytotoxicity and DNA/BSA binding ability of copper(II) complexes with dimethylbithiazole

Abedi, Anita; Lighvan, Zohreh Mehri; Ostad, Seyed Nasser

doi:10.1007/s00706-015-1652-z

Cited by 11 publications

(3 citation statements)

References 47 publications

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“…The quenching constant ( K SV ) is obtained by the classical Stern–Volmer formula (eqn (3)). 26 F 0 / F = 1 + K SV [Complex]where F 0 and F are the fluorescence intensity of the EB-CT-DNA system in the absence and presence of complexes, respectively, and [Complex] is the molar concentration of complexes. The slope is the quenching constant K SV by plotting F 0 / F against [Complex] (Fig.…”

Section: Resultsmentioning

confidence: 99%

Synthesis, characterization and biological activity of novel copper complexes containing a β-carboline derivative and amino acids

et al. 2023

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Section: Resultsmentioning

confidence: 99%

Synthesis, characterization and biological activity of novel copper complexes containing a β-carboline derivative and amino acids

et al. 2023

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“…The results suggested of binding compounds to the CT‐DNA. Typically, molecules containing extended planar aromatic systems could be inserted between base pairs of DNA through π‐π* stacking to give significant unwinding, stiffening and lengthening of the helix and thus function as intercalators . So, compound 1(H)Br could intercalate between base pairs and its cationic form (1(H) + ) could exert electrostatic interaction to anionic phosphate backbone of DNA.…”

Section: Resultsmentioning

confidence: 99%

Luminescent Palladacycles Containing a Pyrene Chromophor; Synthesis, Biological and Computational Studies of the Interaction with DNA and BSA

et al. 2019

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One of the most active areas within the field of bioorganometallic chemistry, complexes of N-heterocyclic carbenes (NHCs), have recently gained interest. Herein, we report two luminescent palladium N-heterocyclic carbene complexes; namely [Pd {(C,N)-C 6 H 4 CH 2 NH(CH 2 CH 3 )}(1)] (2) and [Pd{(C,N)-C 6 H 4 CH 2 NH 2 }(1)] (3) (1 = 1-methyl-3-(2-oxo-2-(pyren-1-yl)ethyl)-2,3-dihydroimidazol-2-ylidene) which were synthesized from the reaction of luminescent imidazolium salt (1(H)Br) and binuclear Palladacycles. The interactions of them with CT-DNA evaluated via absorption, emission and CD spectral techniques as well as measurements of viscosity and thermal denaturation and the results have been shown that they bounded to CT-DNA by intercalation and groove binding modes. The in vitro cytotox-icity of compounds 2-3 and 1(H)Br on human breast (MCF-7) and cervical epithelial carcinoma (HeLa) cancer cells lines, indicated the wide range of anticancer activities of them with low IC 50 values. Moreover, based on the protein binding ability studies, the intrinsic fluorescence of BSA could be strongly quenched by compounds via a static quenching mechanism. Competitive binding study using Eosin, Digoxin and Ibuprofen as site markers, indicated that the compounds could bind to sites I and II on BSA structure. Finally, all data obtained from biophysical studies were validated by molecular modeling study. Computational results showed that palladium complexes have the potential for detection of mismatch DNA.

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“…Binding to biomacromolecules is usually associated with modifications of the electronic spectrum of both the compounds, which is interacting or the biomolecule . It is generally agreed that hypochromism and bathochromism effects mean an intercalation of the metallodrug to DNA associated with strong (π → π*) stacking interactions between aromatic chromophores of the studied binding complex and DNA base pairs. , Additionally, the hyperchromism effect is usually associated with the interaction of the metal complex with the minor groove of DNA, meaning an unwinding of the DNA double helix leading to unstack and exposure of the nitrogen bases of the DNA chain. , As an example, Figure shows the electronic absorption spectra of 3 (one of the most active compounds of the present series) in the absence and presence of FS-DNA.…”

Section: Resultsmentioning

confidence: 99%

Bioactive Heterometallic Cu^II–Zn^II Complexes with Potential Biomedical Applications

Majumder

Chakraborty²,

Álvarez

et al. 2018

ACS Omega

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A series of multinuclear heterometallic Cu–Zn complexes of molecular formula [(CuL)2Zn(dca)2] (1), [(CuL)2Zn(NO3)2] (2), [(CuL)2Zn2(Cl)4] (3), and [(CuL)2Zn2(NO2)4] (4) have been synthesized by reacting [CuL] as a “metalloligand (ML)” (where HL = N,N′-bis(5-chloro-2-hydroxybenzylidene)-2,2-dimethylpropane-1,3-diamine) and by varying the anions or coligands using the same molar ratios of the reactants. All of the four products including the ML have been characterized by infrared and UV–vis spectroscopies and elemental and single-crystal X-ray diffraction analyses. By varying the anions, different structures and topologies are obtained which we have tried to rationalize by means of thorough density functional theory calculations. All of the complexes (1–4) have now been applied for several biological investigations to verify their therapeutic worth. First, their cytotoxicity properties were assessed against HeLa human cervical carcinoma along with the determination of IC50 values. The study was extended with extensive DNA and protein binding experiments followed by detailed fluorescence quenching study with suitable reagents to comprehend the mechanistic pathway. From all of these biological studies, it has been found that all of these heterometallic complexes show more than a few fold improvement of their therapeutic values as compared to the similar homometallic ones probably because of the simultaneous synergic effect of copper and zinc. Among all of the four heterometallic complexes, complex 3 exhibits highest binding constants and IC50 values suggest for their better interaction toward the biological targets and hence have better clinical importance.

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Cytotoxicity and DNA/BSA binding ability of copper(II) complexes with dimethylbithiazole

Cited by 11 publications

References 47 publications

Synthesis, characterization and biological activity of novel copper complexes containing a β-carboline derivative and amino acids

Synthesis, characterization and biological activity of novel copper complexes containing a β-carboline derivative and amino acids

Luminescent Palladacycles Containing a Pyrene Chromophor; Synthesis, Biological and Computational Studies of the Interaction with DNA and BSA

Bioactive Heterometallic Cu^II–Zn^II Complexes with Potential Biomedical Applications

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Cytotoxicity and DNA/BSA binding ability of copper(II) complexes with dimethylbithiazole

Cited by 11 publications

References 47 publications

Synthesis, characterization and biological activity of novel copper complexes containing a β-carboline derivative and amino acids

Synthesis, characterization and biological activity of novel copper complexes containing a β-carboline derivative and amino acids

Luminescent Palladacycles Containing a Pyrene Chromophor; Synthesis, Biological and Computational Studies of the Interaction with DNA and BSA

Bioactive Heterometallic CuII–ZnII Complexes with Potential Biomedical Applications

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Product

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Bioactive Heterometallic Cu^II–Zn^II Complexes with Potential Biomedical Applications