Cytotoxicity and Genotoxicity of Copper oxide Nanoparticles in chickens

Morsy, E.A.; Hussien, Ahmed; Ibrahim, Marwa A.; Farroh, Khaled Yehia; Hassanen, Eman I.

doi:10.1007/s12011-021-02595-4

Cited by 39 publications

(23 citation statements)

References 57 publications

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“…This was supported by other literature stating that copper at sufficient dietary levels has favorable impacts, but severe toxic effects as a result of extra copper are well established [ 49 , 50 ]. The study of Morsy et al [ 51 ] investigated the oral administration of copper oxide nanoparticles (CuO-NPs) at doses 5 mg/kg and 15 mg/kg BW in broiler chickens. They showed a notable decrease in weight gain, FCR in a level-dependent manner.…”

Section: Discussionmentioning

confidence: 99%

“…Another study showed that curcumin supplementation reduced genomic and cellular DNA damage in mice exposed to 390 ppm Cu [ 91 ]. Morsy et al [ 51 ] reported increased DNA fragmentation percent and microscopic recording in various inspected organs of chickens received CuO-NPs.…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, other studies exhibited a significant inflammatory cell infiltration and hepatocyte vacuolar degeneration [ 105 ], severe microscopic changes, including vacuolar degeneration, local tissue necrosis, and blurred hepatic lobules in birds-supplemented with 300 mg Cu/kg diet [ 47 ]. Morsy et al [ 51 ] observed histopathological changes in chickens getting CuO-NPs with some differences in its severity. Our results differ from other findings that showed that birds fed a high level of copper diet did not alter any histological tissue [ 106 ].…”

Section: Discussionmentioning

confidence: 99%

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Mitigating the Growth, Biochemical Changes, Genotoxic and Pathological Effects of Copper Toxicity in Broiler Chickens by Supplementing Vitamins C and E

Hashem

Hamied

Ahmed

et al. 2021

Animals

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This experiment was carried out to explore the efficiency of an individual or combined doses of vitamin C (Vit. C) and vitamin E (Vit. E) in alleviating biochemical, genotoxicity, and pathological changes in the liver induced by copper sulfate (CuSO4) toxicity in broiler chickens. Two hundred and fifty-one-day-old broiler chicks were haphazardly allotted into five groups (five replicates/group, ten chicks/replicate). The birds were fed five experimental diets; (1) basal diet with no additives (CON), (2) basal diets supplemented with 300 mg CuSO4/kg diet (CuSO4), (3) basal diets supplemented with 300 mg CuSO4/kg diet + 250 mg Vit. C /kg diet, (4) basal diets supplemented with 300 mg CuSO4/kg diet +250 mg Vit. E /kg diet, (5) basal diets supplemented with 300 mg CuSO4/kg diet + 250 mg Vit. C /kg diet + 250 mg Vit. E /kg diet for six weeks. The results displayed that CuSO4-intoxicated birds had significantly (p < 0.05) decreased bodyweight, weight gain, and feed intake with increased feed conversion ratio from the 2nd week till the 6th week compared with the CON. However, these changes were minimized by single or combined supplementation of vitamin C and E. The FCR was insignificantly different in birds-fed diets complemented with vitamin C and E singly or in combination from the 3rd week of age compared to the CON. Serum aminotransferases (ALT, AST) and alkaline phosphatase (ALP) were elevated in CuSO4-intoxicated birds (p < 0.05). Additionally, they showed a drop in serum total protein (TP), albumin, globulins, triglycerides (TG), total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), very low-density lipoprotein-cholesterol (VLDL-C), and high-density lipoprotein-cholesterol (HDL-C) levels compared to the CON (p < 0.05). Concomitantly, histopathological and DNA changes were perceived in the liver of CuSO4-intoxicated birds. Co-supplementation of Vit. C and Vit. E single-handedly or combined with CuSO4-intoxicated chickens enhanced the performance traits and abovementioned changes, especially with those given combinations of vitamins. From the extant inquiry, it could be established that supplementation of vitamin C and E was beneficial for mitigating the harmful effects of CuSO4 toxicity on growth performance and liver histoarchitecture in broiler chickens.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Mitigating the Growth, Biochemical Changes, Genotoxic and Pathological Effects of Copper Toxicity in Broiler Chickens by Supplementing Vitamins C and E

Hashem

Hamied

Ahmed

et al. 2021

Animals

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“…e body reacts in a different way with similar mass composed of billions of NPs in comparison with many microparticles. e engineered nanoparticles possess high surface reactivity, as well as high surface area, which could result in producing higher reactive oxygen species level, thus leading to cytotoxicity and genotoxicity [17,18].…”

Section: Size and Surface Areamentioning

confidence: 99%

Toxicity of Nanoparticles in Biomedical Application: Nanotoxicology

Egbuna

Parmar

Jeevanandam

et al. 2021

Journal of Toxicology

194

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Nanoparticles are of great importance in development and research because of their application in industries and biomedicine. The development of nanoparticles requires proper knowledge of their fabrication, interaction, release, distribution, target, compatibility, and functions. This review presents a comprehensive update on nanoparticles’ toxic effects, the factors underlying their toxicity, and the mechanisms by which toxicity is induced. Recent studies have found that nanoparticles may cause serious health effects when exposed to the body through ingestion, inhalation, and skin contact without caution. The extent to which toxicity is induced depends on some properties, including the nature and size of the nanoparticle, the surface area, shape, aspect ratio, surface coating, crystallinity, dissolution, and agglomeration. In all, the general mechanisms by which it causes toxicity lie on its capability to initiate the formation of reactive species, cytotoxicity, genotoxicity, and neurotoxicity, among others.

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“…9 However, their increased exposure may cause inflammation, genotoxicity, and oxidative stress, leading to cancer and metabolic diseases. 10 Different types of inorganic nanoparticles and their associated toxicities are mentioned in Table 1.…”

Section: Types Of Inorganic Nanoparticles and Their Toxicitymentioning

confidence: 99%

Inorganic Nanoparticles: Toxic Effects, Mechanisms of Cytotoxicity and Phytochemical Interactions

et al. 2021

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During the last few decades, nanotechnology has gained many applications in almost all fields of life because of the unique properties of nanoparticles. Nanotechnology has specially marked its name in the field of medicine. However, nanoparticles toxicity is detrimental to human health and is a prime concern in applied medicine. They can cause insomnia, vertigo, madarosis, epistaxis, hypokalemia, lymphopenia, Alzheimer's and Parkinson's diseases, etc. There is a gap in knowledge regarding the study of the toxicological effects of nanoparticles. Mechanisms that are responsible for this toxicity are not fully understood yet. Phytochemicals have natural therapeutic effects of reducing metal nanoparticles' toxicity by acting as stabilizers and nontoxic reducing agents. However, the interaction between phytochemicals and nanoparticles is remained to be elucidated. This review will provide in-depth knowledge about the various types of inorganic nanoparticles and their associated toxicities, key parameters determining the toxic behaviour of nanoparticles, and the mechanisms behind their cytotoxicity. It also emphasizes the need for further research to understand the interaction between various phytochemicals and nanoparticles for therapeutic purposes.

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Cytotoxicity and Genotoxicity of Copper oxide Nanoparticles in chickens

Cited by 39 publications

References 57 publications

Mitigating the Growth, Biochemical Changes, Genotoxic and Pathological Effects of Copper Toxicity in Broiler Chickens by Supplementing Vitamins C and E

Mitigating the Growth, Biochemical Changes, Genotoxic and Pathological Effects of Copper Toxicity in Broiler Chickens by Supplementing Vitamins C and E

Toxicity of Nanoparticles in Biomedical Application: Nanotoxicology

Inorganic Nanoparticles: Toxic Effects, Mechanisms of Cytotoxicity and Phytochemical Interactions

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