Cytotoxicity and Internalization of Polymer Hydrogel Capsules by Mammalian Cells

Zelikin, Alexander N.; Breheney, Kerry; Robert, Rémy; Tjipto, Elvira; Wark, Kim L.

doi:10.1021/bm100500v

Cited by 40 publications

(52 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similarly for hydrogel discs, Merkel et al demonstrated prolonged circulation for particles with diameter comparable to RBCs, as compared to smaller particles of identical composition [46]. As discussed later in this review, carrier mechanical flexibility can generally confound trends relating clearance time to particle size, where softer particles generally exhibit longer circulation times related to altered hemodynamic behavior [43, 47] and interactions with phagocytic cells [48,49]. …”

Section: Modulation Of Pharmacokinetics and Targeting By Carrier Gmentioning

confidence: 99%

Non-affinity factors modulating vascular targeting of nano- and microcarriers

Myerson¹,

Anselmo

Liu

et al. 2016

Advanced Drug Delivery Reviews

View full text Add to dashboard Cite

Particles capable of homing and adhering to specific vascular biomarkers have potential as fundamental tools in drug delivery for mediation of a wide variety of pathologies, including inflammation, thrombosis, and pulmonary disorders. The presentation of affinity ligands on the surface of a particle provides a means of targeting the particle to sites of therapeutic interest, but a host of other factors come into play in determining the targeting capacity of the particle. This review presents a summary of several key considerations in nano- and microparticle design that modulate targeted delivery without directly altering epitope-specific affinity. Namely, we describe the effect of factors in definition of the base carrier (including shape, size, and flexibility) on the capacity of carriers to access, adhere to, and integrate in target biological milieus. Furthermore, we present a summary of fundamental dynamics of carrier behavior in circulation, taking into account interactions with cells in circulation and the role of hemodynamics in mediating the direction of carriers to target sites. Finally, we note non-affinity aspects to uptake and intracellular trafficking of carriers in target cells. In total, recent findings presented here may offer an opportunity to capitalize on mitigating factors in the behavior of ligand-targeted carriers in order to optimize targeting.

show abstract

Section: Modulation Of Pharmacokinetics and Targeting By Carrier Gmentioning

confidence: 99%

Non-affinity factors modulating vascular targeting of nano- and microcarriers

Myerson¹,

Anselmo

Liu

et al. 2016

Advanced Drug Delivery Reviews

View full text Add to dashboard Cite

show abstract

“…[76][77][78][79][80][81][82][83][84][85][86] PEG corona on capsules' surface Avoiding rapid clearance following in vivo administration…”

Section: Light-responsive Releasementioning

confidence: 99%

“…To date, only limited in vitro data have been reported while barely any in vivo data on their performance are available. Efficient uptake of redox-responsive capsules by various cell types has been demonstrated [81]. Yan and colleagues demonstrated that thiol groups and disulfide bonds in the poly(methacrylic acid) (PMA SH ) capsules enhance cellular association and uptake via exofacial thiols on the cell membrane.…”

Section: Redox-responsive Capsulesmentioning

confidence: 99%

See 1 more Smart Citation

Tailoring Layer-By-Layer Capsules for Biomedical Applications

et al. 2012

View full text Add to dashboard Cite

Polymeric capsules have attracted great interest as versatile carrier systems in the area of medicine and pharmaceutics. These capsules are made by stepwise layer-by-layer adsorption of polymers onto a template core, which can be removed to produce hollow capsules. The cavity of these capsules can host various cargo molecules while the capsules' wall can be functionalized towards desired properties by embedding specific moieties into the multilayers. Tuning of the capsules' properties influences their interaction with cells and tissues and paves the way towards the development of stimuli-responsive capsules releasing their payload at a target site. In this review, we describe the generation of tailored layer-by-layer capsules and focus hereby on numerous potential applications of this multifunctional delivery platform in biomedical settings. We review the current status in the field and discuss the opportunities, as well as the hurdles, to be overcome to successfully transfer this technology to therapeutic and diagnostic applications.

show abstract

“…Moreover, Zelikin et a. have synthesized a nanostructural material in form of polymer hydrogel capsules comprised of PMA chains and cross-linked via disulfide linkages (PMA HC) [45]. They investigated the interactions of PMA HC with a range of mammalian cells and demonstrated that the capsules were effectively internalized by all mammalian cells lines, both adherent and nonadherent.…”

Section: Covalent Attachment Of Polymermentioning

confidence: 99%

Nanostructural Hybrid Sensitizers for Photodynamic Therapy

Kępczyński

Dzieciuch²,

Nowakowska³

2012

CPD

View full text Add to dashboard Cite

Photodynamic therapy (PDT) is a clinically approved method for treatment of cancer, microbial infections, and some other diseases. PDT has proved effective in the treatment of malignancies of various organs, including lung, bladder, gastrointestinal tract, and skin, and in the therapy of bacterial infection of skin wounds and carious lesions. It employs a combination of light and a drug (photosensitizer, PS) to induce phototoxicity against cancerous cells or bacteria. The efficiency of currently used PSs is limited due to their hydrophobic nature, which causes aggregation of the PS in aqueous media and low tumor selectivity (a low value of the tumor-to-normal tissue ratio). The purpose of this review is to present some aspects of the current state of knowledge on nanostructural carriers for the PS delivery. In this paper we reviewed studies on the development of nanostructural materials for PDT, especially those based on the polymeric and liposomal formulation of PS. We focused mainly on the nanostructural PSs obtained by the covalent attachment of hydrophilic polymer chain to the low-molecular-weight PS, the incorporation of PS into polymeric nanostructures such as micelles, and the solubilization of PS in liposome carriers.

show abstract

Cytotoxicity and Internalization of Polymer Hydrogel Capsules by Mammalian Cells

Cited by 40 publications

References 41 publications

Non-affinity factors modulating vascular targeting of nano- and microcarriers

Non-affinity factors modulating vascular targeting of nano- and microcarriers

Tailoring Layer-By-Layer Capsules for Biomedical Applications

Nanostructural Hybrid Sensitizers for Photodynamic Therapy

Contact Info

Product

Resources

About