Cytotoxicity and osteogenic effects of aluminum ions

Mizuno, Kai; Boschetto, Francesco; Yamamoto, Kenta; Honma, Taigi; Miyamoto, Nao; Adachi, Tetsuya; Kanamura, Narisato; Yamamoto, Toshiro; Zhu, Wenliang; Marin, Elia; Pezzotti, Giuseppe

doi:10.1016/j.jinorgbio.2022.111884

Cited by 9 publications

(1 citation statement)

References 21 publications

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“…The results obtained thus far show that the Nb 2 O 5 thin films deposited on the surface of the Ti-6Al-4V alloy act as a protective physical barrier against the corrosion process in a medium containing Fions 8 . Consequently, they should prevent the release of aluminum (Al) and vanadium (V) ions that may be related to adverse reactions and that are harmful to the body [10][11][12] .…”

Section: Introductionmentioning

confidence: 99%

Influence of Reactive Sputtering-Deposited Nb2O5 Coating On the Ti-6Al-4V Alloy Surfaces: Biomineralization, Antibacterial Activity, and Cell Viability Tests

Nascimento,

Teixeira,

Obata

et al. 2023

Mat. Res.

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Biomedical engineering has been constantly looking for the development of new materials that have bioactive surfaces and that are responsible for new bone formation, induce osteoblast differentiation and present antibacterial properties. Here, we present innovative and applied research to evaluate the influence of niobium pentoxide thin films (Nb 2 O 5 ) deposited on the surface of a Ti-6Al-4V alloy via the reactive sputtering technique on antibacterial activity, on the cellular proliferation of MC3T3 cells and on biomineralization capacity. Results demonstrated the reactive sputtering technique improved the cell viability, the osteogenic performance of cells involved in the osseointegration process, the ability to delay bacterial proliferation within the first six hours of contact with S. aureus as well as the capacity to promote rapid amorphous apatite formation in vitro. These findings confirm the great potential of the Ti-6Al-4V alloy functionalized with Nb 2 O 5 for future applications in implantable devices.

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Section: Introductionmentioning

confidence: 99%

Influence of Reactive Sputtering-Deposited Nb2O5 Coating On the Ti-6Al-4V Alloy Surfaces: Biomineralization, Antibacterial Activity, and Cell Viability Tests

Nascimento,

Teixeira,

Obata

et al. 2023

Mat. Res.

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Rethinking Biomedical Titanium Alloy Design: A Review of Challenges from Biological and Manufacturing Perspectives

Rabbitt,

Villapún,

Carter

et al. 2024

Adv Healthcare Materials

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Current biomedical titanium alloys have been repurposed from other industries, which has contributed to several biologically driven implant failure mechanisms. This review highlights the added value that may be gained by building an appreciation of implant biological responses at the onset of alloy design. Specifically, the fundamental mechanisms associated with immune response, angiogenesis, osseointegration and the potential threat of infection are discussed, including how elemental selection can modulate these pivotal systems. With a view to expedite inclusion of these interactions in alloy design criteria, methods to analyze these performance characteristics are also summarized. While machine learning techniques are being increasingly used to unearth complex relationships between alloying elements and material properties, much is still unknown about the correlation between composition and some bio‐related properties. To bridge this gap, high‐throughput methods are also reviewed to validate biological response along with cutting edge manufacturing approaches that may support rapid discovery. Taken together, this review encourages the alloy development community to rethink their approach to enable a new generation of biomedical implants intrinsically designed for a life in the body, including functionality to tackle biological challenges thereby offering improved patient outcomes.

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From Ancient Remedies to Modern Contraptions: Tracing the Evolution of Biocompatible Materials

Marin,

Basoli

2024

Engineering Methodologies for Medicine and Sports

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Cytotoxicity and osteogenic effects of aluminum ions

Cited by 9 publications

References 21 publications

Influence of Reactive Sputtering-Deposited Nb2O5 Coating On the Ti-6Al-4V Alloy Surfaces: Biomineralization, Antibacterial Activity, and Cell Viability Tests

Influence of Reactive Sputtering-Deposited Nb2O5 Coating On the Ti-6Al-4V Alloy Surfaces: Biomineralization, Antibacterial Activity, and Cell Viability Tests

Rethinking Biomedical Titanium Alloy Design: A Review of Challenges from Biological and Manufacturing Perspectives

From Ancient Remedies to Modern Contraptions: Tracing the Evolution of Biocompatible Materials

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