Cytotoxicity and physicochemical properties of hafnium oxide nanoparticles

Field, James A.; Luna-Velasco, Antonia; Boitano, Scott; Shadman, Farhang; Ratner, Buddy D.; Barnes, Chris; Sierra-Álvarez, Reyes

doi:10.1016/j.chemosphere.2011.04.067

Cited by 52 publications

(41 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, hafnium based nanoparticles were grown in situ in GdBa2Cu3O7-δ coated conductors to improve the critical current of the superconductor (Tobita et al 2012). Even the use in biological applications should not be excluded because of the negligible cytotoxicity of HfO2 (Field et al 2011). Hafnium oxide nanoparticles have already been synthesized with a variety of methods, such as surfactant based (Dahal and Chikan 2012;Tang et al 2004;Chaubey et al 2012;Tirosh and Markovich 2007), hydrothermal (Stefanic et al 2005), microwave assisted hydrothermal (Eliziario et al 2009), ultrasonically assisted hydrothermal (Meskin et al 2007), solvothermal (Pinna et al 2004;Pucci et al 2009;Boyle et al 2012;Buha et al 2010), precipitation ) and sonochemical synthesis .…”

Section: Introductionmentioning

confidence: 99%

Fast, microwave-assisted synthesis of monodisperse HfO2 nanoparticles

et al. 2013

View full text Add to dashboard Cite

A conventional solvothermal synthesis was compared to a microwave assisted method for the synthesis of HfO2 nanoparticles. In a microwave, the reaction could be completed in three hours, compared to three days in an autoclave. In the microwave synthesis the ensemble of particles was found to have a better size dispersion and a smaller average size (4 nm). The reaction mechanism was investigated and proof for an ether elimination process was provided. Post-synthetic modification with dopamine or dodecanoic acid permitted the suspension of the synthesized particles in both polar and apolar solvents, which is an advantage for further processing.keywords: Benzyl alcohol, microwave, ligand exchange, hafnium oxide 2

show abstract

Section: Introductionmentioning

confidence: 99%

Fast, microwave-assisted synthesis of monodisperse HfO2 nanoparticles

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Nanotechnology-enabled diagnostic and therapeutics based on dendrimers 67–69 , gold 70–72 , silica 73–75 , iron oxide 71,76,77 and hafnium oxide 78,79 are also currently under clinical investigation, with the majority intended for oncological applications (TABLE 1). For example gold NPs decorated with a surface of PEG conjugated to TNFα molecules are in phase I/II trials for solid tumour therapy 80 .…”

Section: Nanomedicinesmentioning

confidence: 99%

Nanomedicines for renal disease: current status and future applications

et al. 2016

View full text Add to dashboard Cite

Treatment and management of kidney disease currently presents an enormous global burden, and the application of nanotechnology principles to renal disease therapy, although still at an early stage, has profound transformative potential. The increasing translation of nanomedicines to the clinic, alongside research efforts in tissue regeneration and organ-on-a-chip investigations, are likely to provide novel solutions to treat kidney diseases. Our understanding of renal anatomy and of how the biological and physicochemical properties of nanomedicines (the combination of a nanocarrier and a drug) influence their interactions with renal tissues has improved dramatically. Tailoring of nanomedicines in terms of kidney retention and binding to key membranes and cell populations associated with renal diseases is now possible and greatly enhances their localization, tolerability, and efficacy. This Review outlines nanomedicine characteristics central to improved targeting of renal cells and highlights the prospects, challenges, and opportunities of nanotechnology-mediated therapies for renal diseases.

show abstract

“…Surgery will follow, which should provide interesting pathologic and pharmacokinetic information. Preclinical, in vitro data have shown this NP to be relatively inert and nontoxic, raising the hope for an effective clinical application of metal NPs [107]. …”

Section: Np Therapeutics Used In Chemoradiationmentioning

confidence: 99%

Nanomedicine in Chemoradiation

Miller¹,

Wang²

2013

Therapeutic Delivery

View full text Add to dashboard Cite

Chemoradiotherapy, the concurrent administration of chemotherapy and radiotherapy, is a treatment paradigm in oncology. It is part of the standard of care and curative treatment of many cancers. Given its importance, one of the primary goals of cancer research has been to identify agents and/or strategies that can improve the therapeutic index of chemoradiation. Recent advances in nanomedicine have provided a unique and unprecedented opportunity for improving chemoradiotherapy. Nanoparticles possess properties that are ideally suited for delivering chemotherapy in the chemoradiation setting. The goal of this review is to examine the role of incorporating nanomedicine into chemoradiation and the potential impact of nanomedicine to chemoradiotherapy.

show abstract

Cytotoxicity and physicochemical properties of hafnium oxide nanoparticles

Cited by 52 publications

References 35 publications

Fast, microwave-assisted synthesis of monodisperse HfO2 nanoparticles

Fast, microwave-assisted synthesis of monodisperse HfO2 nanoparticles

Nanomedicines for renal disease: current status and future applications

Nanomedicine in Chemoradiation

Contact Info

Product

Resources

About