Cytotoxicity Assessment of PM2.5 Collected from Specific Anthropogenic Activities in Taiwan

Ngo, Tuan Hung; Tsai, Pei Chun; Ueng, Yune-Fang; Hsien, Kai

doi:10.3390/ijerph16245043

Cited by 7 publications

(4 citation statements)

References 38 publications

(45 reference statements)

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“…Health impacts related to unsafe air quality have been the subject of many studies, and focus on correlating particulate matter concentrations and premature mortality as well as related economic losses [ 8 , 12 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 ]. Some of these studies were performed using Thai populations [ 27 , 28 , 29 , 30 ].…”

Section: Introductionmentioning

confidence: 99%

An Assessment of Annual Mortality Attributable to Ambient PM2.5 in Bangkok, Thailand

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Allison

Wood

et al. 2020

IJERPH

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Multiple studies indicate that PM2.5 is the most deleterious air pollutant for which there are ambient air quality standards. Daily concentrations of PM2.5 in Bangkok, Thailand, continuously exceed the World Health Organization (WHO) and the Thai National Ambient Air Quality Standards (NAAQSs). Bangkok has only recently begun to measure concentrations of PM2.5. To overcome this paucity of data, daily PM2.5/PM10 ratios were generated over the period 2012–2018 to interpolate missing values. Concentration-response coefficients (β values) for PM2.5 versus non-accidental, cardiopulmonary, and lung cancer mortalities were derived from the literature. Values were also estimated and were found to be comparable to those reported in the literature for a Chinese population, but considerably lower than those reported in the literature from the United States. These findings strongly suggest that specific regional β values should be used to accurately quantify the number of premature deaths attributable to PM2.5 in Asian populations. Health burden analysis using the Environmental Benefits Mapping and Analysis Program (BenMAP) showed that PM2.5 concentration in Bangkok contributes to 4240 non-accidental, 1317 cardiopulmonary, and 370 lung cancer mortalities annually. Further analysis showed that the attainment of PM2.5 levels to the NAAQSs and WHO guideline would reduce annual premature mortality in Bangkok by 33%and 75%, respectively.

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Section: Introductionmentioning

confidence: 99%

An Assessment of Annual Mortality Attributable to Ambient PM2.5 in Bangkok, Thailand

Fold

Allison

Wood

et al. 2020

IJERPH

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“…In our previous study of PM 2.5 in northern Taiwan, the results showed that traffic activity generates higher PM 2.5 concentration (mg/m 3 ) than long-range transport events and outdoor cooking (night market) 28 . The potential factors influencing the PM 2.5 composition in vehicle emissions include fuel type, engine age, running distance, vehicle displacement (c.c.…”

Section: Discussionmentioning

confidence: 85%

“…The aqueous extracts of PM 2.5 samples were filtered using a glass syringe and a 20 mm polytetrafluoroethylene (PTFE) filter (Advantec Toyo Kaisha, Ltd., Tokyo, Japan). The filtrate was subjected to ion chromatography using Dionex ICS-1000 (Thermo Fisher Scientific Inc., Waltham, MA, USA) to determine the ionic content (recovery range of 88–104%) 28 with a detection limit of 0.01–10.1 µg.…”

Section: Methodsmentioning

confidence: 99%

Sub-toxic events induced by truck speed-facilitated PM2.5 and its counteraction by epigallocatechin-3-gallate in A549 human lung cells

Pan

Hsien

Wang

et al. 2022

Sci Rep

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To distinguish the influences of fuel type and truck speed on chemical composition and sub-toxic effects of particulates (PM2.5) from engine emissions, biomarkers—interleukin-6 (IL-6), cytochrome P450 (CYP) 1A1, heme oxygenase (HO)-1, and NADPH-quinone oxidoreductase (NQO)-1—were studied in A549 human lung cells. Fuel type and truck speed preferentially affected the quantity and ion/polycyclic aromatic hydrocarbon (PAH) composition of PM2.5, respectively. Under idling operation, phenanthrene was the most abundant PAH. At high speed, more than 50% of the PAHs had high molecular weight (HMW), of which benzo[a]pyrene (B[a]P), benzo[ghi]perylene (B[ghi]P), and indeno[1,2,3-cd]pyrene (I[cd]P) were the main PAHs. B[a]P, B[ghi]P, and I[cd]P caused potent induction of IL-6, CYP1A1, and NQO-1, whereas phenanthrene mildly induced CYP1A1. Based on the PAH-mediated induction, the predicted increases in biomarkers were positively correlated with the measured increases. HMW-PAHs contribute to the biomarker induction by PM2.5, at high speed, which was reduced by co-exposure to epigallocatechin-3-gallate.

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“…[11] Different cell lines were used, depending on the environment assessed and exposure routes implicated. The A549 alveolar epithelial cell line was used in four outdoor environment studies [12,13] and for occupational exposure in the waste sorting industry [11,14]. Lymphocytes were used in two studies of occupational and outdoor environments [15,16].…”

Section: Cytotoxicity Of Filtering Respiratory Protective Devices Fro...mentioning

confidence: 99%

Are In Vitro Cytotoxicity Assessments of Environmental Samples Useful for Characterizing the Risk of Exposure to Multiple Contaminants at the Workplace? A Systematic Review

Viegas

Pena

Gomes

et al. 2022

Toxics

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In some occupational environments risk characterization is challenging or impossible to achieve due to the presence of multiple pollutants and contaminants. Thus, in vitro testing using the most relevant cell lines will provide information concerning health effects due to the co-exposure to multiple stressors. The aim of this review article is to identify studies where the cytotoxicity assessment was performed in environmental samples, as well as to describe the main outputs and challenges regarding risk characterization and management. This study is based on a study of the available information/data on cytotoxicity assessment performed on environmental samples following the PRISMA methodology. Different cell lines were used depending on the environment assessed and exposure routes implicated. The A549 alveolar epithelial cell line was applied in four studies for occupational exposure in the waste sorting industry and for outdoor environments; lymphocytes were used in two studies for occupational and outdoor environments; swine kidney cells were used in three studies performed in the waste industry and hepatocellular/Hep G2 in one study in the waste industry. Cytotoxicity assessments in environmental samples should have a more prominent role due to their contribution for identifying and better understanding the associations between co-exposure to environmental contaminants and adverse human health effects as a prioritization for risk management.

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Cytotoxicity Assessment of PM2.5 Collected from Specific Anthropogenic Activities in Taiwan

Cited by 7 publications

References 38 publications

An Assessment of Annual Mortality Attributable to Ambient PM2.5 in Bangkok, Thailand

An Assessment of Annual Mortality Attributable to Ambient PM2.5 in Bangkok, Thailand

Sub-toxic events induced by truck speed-facilitated PM2.5 and its counteraction by epigallocatechin-3-gallate in A549 human lung cells

Are In Vitro Cytotoxicity Assessments of Environmental Samples Useful for Characterizing the Risk of Exposure to Multiple Contaminants at the Workplace? A Systematic Review

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