Cytotoxicity control of silicon nanoparticles by biopolymer coating and ultrasound irradiation for cancer theranostic applications

Sviridov, Andrey; Осминкина, Л. А.; Kharin, Alexander; Gongalsky, M. B.; Kargina, J V; Kudryavtsev, A. A.; Bezsudnova, Yulia; Perova, Tatiana S.; Géloën, Alain; Lysenko, V.; Timoshenko, V. Yu.

doi:10.1088/1361-6528/aa5b7c

Cited by 45 publications

(26 citation statements)

References 43 publications

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“…Therapeutic ultrasound irradiation of cancer cells with the incorporated nSi resulted in a decrease in the number of living cells, while the total number of cells remained nearly constant. The results show the possibilities of applications of porous nSi with dextran coating in both diagnostics and cancer sonodynamic therapy [60].…”

Section: Biopolymers and Biopolymer Nanocompositesmentioning

confidence: 80%

Polymers and Polymer Nanocomposites for Cancer Therapy

Feldman

2019

Applied Sciences

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Synthetic polymers, biopolymers, and their nanocomposites are being studied, and some of them are already used in different medical areas. Among the synthetic ones that can be mentioned are polyolefins, fluorinated polymers, polyesters, silicones, and others. Biopolymers such as polysaccharides (chitosan, hyaluronic acid, starch, cellulose, alginates) and proteins (silk, fibroin) have also become widely used and investigated for applications in medicine. Besides synthetic polymers and biopolymers, their nanocomposites, which are hybrids formed by a macromolecular matrix and a nanofiller (mineral or organic), have attracted great attention in the last decades in medicine and in other fields due to their outstanding properties. This review covers studies done recently using the polymers, biopolymers, nanocomposites, polymer micelles, nanomicelles, polymer hydrogels, nanogels, polymersomes, and liposomes used in medicine as drugs or drug carriers for cancer therapy and underlines their responses to internal and external stimuli able to make them more active and efficient. They are able to replace conventional cancer drug carriers, with better results. Appl. Sci. 2019, 9, 3899 2 of 24 nanocomposites offer numerous opportunities in diverse applications, including nanocarriers, tissue engineering, antimicrobials, sensors, etc. These new groups of materials have gained significant research interest due to their novel properties, which are gained through the addition of nanofillers. Polymer nanocomposites have significant potential in disease theranostics, and nanotechnology brings great promise in cancer drug carriers [4].Chemotherapy implies the use of drugs and, besides the drugs, carriers. Common products used as carriers include synthetic polymers, biopolymers, and polymer nanocomposites.Some of the most useful drugs for chemotherapy are toxic chemicals able to inhibit the proliferation of cancer cells. The use of chemotherapeutic drugs has been in part hindered by their poor solubility in water, their short biological half-life, their lack of targeting ability, and the development of multidrug resistance [5]. In the last decades, nanoparticles have shown significant promise as an oncology treatment modality. Responsive polymers represent a promising class of nanoparticles that can trigger delivery through the exploitation of a specific stimuli. Response to a stimulus is one of the most basic processes found in living systems. A tutorial review highlighted the recent developments in polymer-based approaches to internally responsive nanoparticles for oncology [6].One important goal of medicine is to develop carriers that can selectively deliver anticancer drugs to tumor cells with no or minimal side effects in healthy cells [7,8].Polymers and their nanocomposites in different forms, such as micelles, hydrogels, polymersomes, and liposomes, have important potential in cancer diagnosis and treatment.Nanocomposites are popular in many areas due to properties such as their unique design capacity, eco-friendly nature, ...

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Section: Biopolymers and Biopolymer Nanocompositesmentioning

confidence: 80%

Polymers and Polymer Nanocomposites for Cancer Therapy

Feldman

2019

Applied Sciences

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“…3T3‐L1 cells were grown on special 96‐well plates with bottom electrodes, which possessed measurements of the electrical impedance. The measured cell index was proportional to the cell number, single cell surface area, and adhesion factor (see ref . for more details).…”

Section: Methodsmentioning

confidence: 99%

Bi‐Modal Nonlinear Optical Contrast from Si Nanoparticles for Cancer Theranostics

Kharin

Lysenko

Rogov

et al. 2019

Advanced Optical Materials

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Having negligible toxicity compared to quantum dots based on compound semiconductors [1,2] and being capable of providing efficient imaging and therapeutic functionalities based on its unique physicochemical characteristics, [3][4][5] nanosilicon occupies a particularly important niche related to biological applications. The imaging functionality of nanosilicon typically employs photoluminescence (PL) of quantum-confined excitonic states in silicon (Si) nanocrystals (NCs) with sizes smaller than the exciton Bohr's radius (≈5 nm for the bulk crystalline Si (c-Si)), which enables tracking the presence of Si nanoparticles (NPs) in cells or tissues. [6][7][8][9][10][11][12][13] On the other hand, Si NPs can serve as efficient sensitizers of local heating under external stimuli to initiate hyperthermia-based therapies. As an example, Presenting a safe alternative to conventional compound quantum dots and other functional nanostructures, nanosilicon can offer a series of breakthrough hyperthermia-based therapies under near-infrared, radiofrequency, ultrasound, etc., excitation, but the size range to sensitize these therapies is typically too large (>10 nm) to enable efficient imaging functionality based on photoluminescence properties of quantum-confined excitonic states. Here, it is shown that large Si nanoparticles (NPs) are capable of providing two-photon excited luminescence (TPEL) and second harmonic generation (SHG) responses, much exceeding that of smaller Si NPs, which promises their use as probes for bi-modal nonlinear optical bioimaging. It is finally demonstrated that the combination of TPEL and SHG channels makes possible efficient tracing of both separated Si NPs and their aggregations in different cell compartments, while the resolution of such an approach is enough to obtain 3D images. The obtained bi-modal contrast provides lacking imaging functionality for large Si NPs and promises the development of novel cancer theranostic modalities on their basis.

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“…The combined strategy can potentially overcome the MDR problem in cancer therapy. Sviridov et al 53 prepared SiNPs by mechanically grinding luminescent porous silicon decorated with dextran. They found that dextran-coated SiNPs could significantly decrease cytotoxicity.…”

Section: Nanoparticle-based Cancer Therapymentioning

confidence: 99%

Recent progress on nanoparticle-based drug delivery systems for cancer therapy

Xin

Yin

Zhao

et al. 2017

Cancer Biology & Medicine

229

103

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The development of cancer nanotherapeutics has attracted great interest in the recent decade. Cancer nanotherapeutics have overcome several limitations of conventional therapies, such as nonspecific biodistribution, poor water solubility, and limited bioavailability. Nanoparticles with tuned size and surface characteristics are the key components of nanotherapeutics, and are designed to passively or actively deliver anti-cancer drugs to tumor cells. We provide an overview of nanoparticle-based drug delivery methods and cancer therapies based on tumor-targeting delivery strategies that have been developed in recent years.

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Cytotoxicity control of silicon nanoparticles by biopolymer coating and ultrasound irradiation for cancer theranostic applications

Cited by 45 publications

References 43 publications

Polymers and Polymer Nanocomposites for Cancer Therapy

Polymers and Polymer Nanocomposites for Cancer Therapy

Bi‐Modal Nonlinear Optical Contrast from Si Nanoparticles for Cancer Theranostics

Recent progress on nanoparticle-based drug delivery systems for cancer therapy

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