Cytotoxicity effect of degraded and undegraded kappa and iota carrageenan in human intestine and liver cell lines

Ariffin, Shahrul Hisham Zainal; Yeen, Wong Woan; Abidin, Intan Zarina Zainol; Wahab, Rohaya Megat Abdul; Senafi, Sahidan

doi:10.1186/1472-6882-14-508

Cited by 67 publications

(44 citation statements)

References 70 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For example, a 10 kDa carrageenan fraction obtained from native ι-carrageenan from Euchema spinosum by acid hydrolysis at high temperature did not induce colitis in rats while a 50 kDa fraction was colitogenic [ 84 ]. Inhibition of cell proliferation and induction of apoptosis was shown by a hydrocholic acid degraded κ-carrageenan in intestinal epithelial (Caco-2 and FHs 74 Int) and liver (HepG2 and Fa2N-4) cell lines [ 88 ].…”

Section: Red Seaweeds and Intestinal Mucosal Barrier Functionmentioning

confidence: 99%

“…The latter is characterized by having a greatly reduced molecular mass. While both types inhibit the expression of nitric oxide synthase, only dc-porphyran inhibits the consequent production of nitric oxide in LPS-stimulated RAW264.7 cells [ 88 ]. Likewise, dc-porphyran showed a slightly higher antioxidant activity.…”

Section: Red Seaweeds and Intestinal Mucosal Barrier Functionmentioning

confidence: 99%

“…In contrast to the inhibitory effects of proteins and peptides on macrophage activity, porphyran enriched fractions from P. yezoensis induce macrophage activation [ 69 , 88 ]. As we indicated above, the sulfations are important in the effect of red seaweed oligosaccharides on the activation of macrophages.…”

Section: Red Seaweeds and Intestinal Mucosal Barrier Functionmentioning

confidence: 99%

See 2 more Smart Citations

Proteins and Carbohydrates from Red Seaweeds: Evidence for Beneficial Effects on Gut Function and Microbiota

et al. 2015

View full text Add to dashboard Cite

Based on their composition, marine algae, and namely red seaweeds, are good potential functional foods. Intestinal mucosal barrier function refers to the capacity of the intestine to provide adequate containment of luminal microorganisms and molecules. Here, we will first outline the component of seaweeds and will summarize the effects of these on the regulation of mucosal barrier function. Special attention will be paid to unique components of red seaweeds: proteins and derived peptides (e.g., phycobiliproteins, glycoproteins that contain “cellulose binding domains”, phycolectins and the related mycosporine-like amino acids) together with polysaccharides (e.g., floridean starch and sulfated galactans, such as carrageenans, agarans and “dl-hybrid”) and minerals. These compounds have been shown to exert prebiotic effects, to regulate intestinal epithelial cell, macrophage and lymphocyte proliferation and differentiation and to modulate the immune response. Molecular mechanisms of action of peptides and polysaccharides are starting to be elucidated, and evidence indicating the involvement of epidermal growth factor receptor (EGFR), insulin-like growth factor receptor (IGFR), Toll-like receptors (TLR) and signal transduction pathways mediated by protein kinase B (PKB or AKT), nuclear factor-κB (NF-κB) and mitogen activated protein kinases (MAPK) will also be summarized. The need for further research is clear, but in vivo experiments point to an overall antiinflammatory effect of these algae, indicating that they can reinforce membrane barrier function.

show abstract

Section: Red Seaweeds and Intestinal Mucosal Barrier Functionmentioning

confidence: 99%

Section: Red Seaweeds and Intestinal Mucosal Barrier Functionmentioning

confidence: 99%

Section: Red Seaweeds and Intestinal Mucosal Barrier Functionmentioning

confidence: 99%

See 1 more Smart Citation

Proteins and Carbohydrates from Red Seaweeds: Evidence for Beneficial Effects on Gut Function and Microbiota

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Few studies have suggested carrageenans to have antitumoral activities. Another study reported apoptosis induction in human intestine (Caco-2) and hepatic (HepG2) cell lines, while no toxicity was observed on corresponding normal cell (Ariffin et al, 2014). Another study reported apoptosis induction in human intestine (Caco-2) and hepatic (HepG2) cell lines, while no toxicity was observed on corresponding normal cell (Ariffin et al, 2014).…”

Section: Carrageenansmentioning

confidence: 99%

Seaweeds in Human Health

Déléris

Nazih

Bard

2016

Seaweed in Health and Disease Prevention

View full text Add to dashboard Cite

“…The carrageenans suppressed the growth of breast, colon, liver, and osteosarcoma cell lines (30). In addition, carrageenan extracted from red seaweed of the Rhodophyceae family and L. papillosa showed cytotoxicity via inhibition of cell proliferation and induction of apoptosis in human intestinal cancer, breast cancer, and liver cancer cells (31,32). Consistent with the anticancer activity, the administration of λ-carrageenan stimulated the immune system via up-regulation of proinflammatory IL17A and TNF-α, thereby stimulating the activities of tumor infiltrating M1 macrophages, dendritic cells, and T lymphocytes (33).…”

Section: Inhibition Of Cancer Cell Proliferation and Survival Bymentioning

confidence: 98%

Therapeutic Application of Diverse Marine-derived Natural Products in Cancer Therapy

Yun

Kim

2019

Anticancer Res

View full text Add to dashboard Cite

Natural products (NPs) are useful sources of bioactive compounds and play important roles in the development and discovery of new drugs for diverse human diseases. Most natural products originate from terrestrial species, but diverse marine organisms are another source of new agents for cancer therapy. Natural products derived from marine organisms show diverse pharmacological activities via bioactive secondary metabolites. They regulate biological activities, such as cell proliferation, cell viability, induction of ROS production, ER stress, and apoptosis via modulation of cellular mechanisms in many cancers. Many natural products isolated from marine species require further study to elucidate the efficacy of their biological activity and anticancer effects. In this review, we summarize the biological properties and anticancer effects of diverse natural products extracted from marine organisms and their roles in tumor therapy. Cancer is one of the leading causes of death and an economic burden worldwide (1). Cancer involves an abnormal proliferation of cells and tissues, and is affected by various risk factors such as age, diet, genetics, and environmental factors (2, 3). It is also caused by the mutation of several cancer-related genes called tumor suppressors and oncogenes (4). Cancer also presents the ability of metastasis and recurrence, which are difficult to treat (5). Although conventional anticancer therapy includes both chemotherapy to induce apoptosis of target cancer cells and surgical therapy to remove tumors, these methods are limited by issues of therapeutic efficacy, safety, and side effects. Thus, it is necessary to develop novel strategies for cancer therapy, and natural products (NPs) are a promising source for novel drug development because they show diverse biological activities and anticancer effects via inhibition of tumor growth by interacting with several signaling pathways (6, 7). NPs have been a useful source of bioactive compounds and play an important role in the discovery and development of drugs. Most NPs, originated from terrestrial microbes, fungi, and plants, have been discovered to possess many pharmacologically active factors and used to treat several human diseases. Some of these are utilized as clinically valuable drugs for anticancer therapy (8-10). However, marine organisms have recently attracted substantial attention because 70% of the earth is covered by water, representing 95% of biodiversity (11-13). NPs derived from marine organisms have been researched for novel bioactive secondary metabolites due to their diverse pharmacological activities. Marine environments are estimated to harbor more than one million species and one billion different types of marine microbes (14). Today, around 28,000 new compounds isolated from marine species, such as algae, seaweed, sponges, and starfish, have been reported, and this species diversity provides a diverse array of secondary metabolic products (15, 16). In this review, we present NPs derived from marine environments, and summari...

show abstract

Cytotoxicity effect of degraded and undegraded kappa and iota carrageenan in human intestine and liver cell lines

Cited by 67 publications

References 70 publications

Proteins and Carbohydrates from Red Seaweeds: Evidence for Beneficial Effects on Gut Function and Microbiota

Proteins and Carbohydrates from Red Seaweeds: Evidence for Beneficial Effects on Gut Function and Microbiota

Seaweeds in Human Health

Therapeutic Application of Diverse Marine-derived Natural Products in Cancer Therapy

Contact Info

Product

Resources

About