Cytotoxicity evaluation and antimicrobial studies of starch capped water soluble copper nanoparticles

Valodkar, Mayur; Rathore, Puran Singh; Jadeja, Ravirajsinh N.; Thounaojam, Menaka C.; Devkar, Ranjitsinh; Thakore, Sonal

doi:10.1016/j.jhazmat.2011.11.077

Cited by 130 publications

(66 citation statements)

References 30 publications

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“…Among the biopolymers used, the polysaccharides, cellulose [8, 12], starch [13], and chitosan [14], have received special attention. These are renewable polymers with potential biocompatibility and biodegradability that can be used in a variety of formulations depending on the envisaged functionality [15].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Activity of Nanocomposites of Copper and Cellulose

Pinto

Daina

Sadocco

et al. 2013

BioMed Research International

125

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The design of cheap and safe antibacterial materials for widespread use has been a challenge in materials science. The use of copper nanostructures combined with abundant biopolymers such as cellulose offers a potential approach to achieve such materials though this has been less investigated as compared to other composites. Here, nanocomposites comprising copper nanofillers in cellulose matrices have been prepared by in situ and ex situ methods. Two cellulose matrices (vegetable and bacterial) were investigated together with morphological distinct copper particulates (nanoparticles and nanowires). A study on the antibacterial activity of these nanocomposites was carried out for Staphylococcus aureus and Klebsiella pneumoniae, as pathogen microorganisms. The results showed that the chemical nature and morphology of the nanofillers have great effect on the antibacterial activity, with an increase in the antibacterial activity with increasing copper content in the composites. The cellulosic matrices also show an effect on the antibacterial efficiency of the nanocomposites, with vegetal cellulose fibers acting as the most effective substrate. Regarding the results obtained, we anticipate the development of new approaches to prepare cellulose/copper based nanocomposites thereby producing a wide range of interesting antibacterial materials with potential use in diverse applications such as packaging or paper coatings.

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Section: Introductionmentioning

confidence: 99%

Antibacterial Activity of Nanocomposites of Copper and Cellulose

Pinto

Daina

Sadocco

et al. 2013

BioMed Research International

125

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“…In a study that evaluated the in vitro toxicity of CuNPs in fibroblast cells from mouse embryos showed that Cu 2+ ions are more cytotoxic than covered NPs (CuNPs) [26] as has been reported also for AgNPs and silver ions. Palladium has been used in alloy with gold, silver, and tin as a material for dental restoration for years, and health concerns about his use are due it known effect on the immune system [29,30].…”

Section: Journal Of Nanomaterialsmentioning

confidence: 76%

“…This is because, in the presence of water and oxygen, copper releases positive ions and generates hydroxyl radicals, both of which are highly toxic. In addition, the electrons produced by oxidation reactions interact with water molecules, forming other hydroxyl radicals [26,27].…”

Section: Journal Of Nanomaterialsmentioning

confidence: 99%

Synthesis and Bactericidal Properties of Hyaluronic Acid Doped with Metal Nanoparticles

Cárdenas-Triviño

Ruiz-Parra

Vergara-González

et al. 2017

Journal of Nanomaterials

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A study on the nanoparticles size and the antibacterial properties of hyaluronic acid (HA) doped with nanoparticles is reported. Nanoparticles from gold, silver, copper, and silver palladium with HA support were performed. The solvated metal atom dispersion (SMAD) method with 2-propanol and HA was used. High-resolution transmission electron microscopy (HRTEM), infrared spectroscopy (FT-IR), and thermogravimetric analysis (TGA) were conducted. The average sizes of nanoclusters were as follows: HA-Au = 17.88 nm; HA-Ag = 50.41 nm; HA-Cu = 13.33 nm; and HA-AgPd = 33.22 nm. The antibacterial activity of solutions and films containing nanoparticles against American Type Culture Collection (ATCC) bacterial strains Escherichia coli (EC), Staphylococcus aureus (SA), Staphylococcus epidermidis (SE), and Pseudomonas aeruginosa (PA) was determined. Inhibition was observed for HA-Ag, HA-Cu, and HA-AgPd. Toxicological tests were performed in rats that were injected intraperitoneally with two concentrations of gold, copper, silver, and silver-palladium nanoparticles. No alterations in hepatic parameters, including ALT (alanine aminotransferase), GGT (gamma-glutamyl transpeptidase) bilirubin, and albumin, were observed after 14 days. These films could be used as promoters of skin recovery and Grades I and II cutaneous burns and as scaffolds.

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“…Extensive use of chemotherapy for alleviating symptoms and for treating lung cancer also involves undesired physiological effects. In recent times, metal complexes (Singh et al, 2012;Vyas et al, 2013;Vyas et al, 2014;Ramadevi et al, 2015;Thakore et al, 2015), herbal extracts (Sankhari et al, 2012;Patel et al, 2012), structured nano sized particles (Valodkar et al, 2011;Valodkar et al, 2012) or novel proteins from bacterial or fungal origins (Huang et al, 2002) have been extensively researched as a therapeutic option.…”

Section: Introductionmentioning

confidence: 99%

Cyanobacterial phycoerythrin purified from marine <i>Lyngbya</i> sp. induces apoptosis in lung carcinoma cells

Madamwar

Kaushal

Patel

et al. 2015

Bangladesh J Pharmacol

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Phycoerythrins from various cyanobacterial sources have been extensively studied globally for their therapeutic potentials. This study shows the apoptotic potential of cyanobacterial phycoerythrin isolated, purified and characterized from marine Lyngbya sp. A09DM on human lung carcinoma cells (A549 cell). Results indicated that purified cyanobacterial phycoerythrin accounted for a dose-dependent decrement in cell viability, mitochondrial membrane potential and an increment in lactate dehydrogenase release. Higher dose of cyanobacterial phycoerythrin caused loss of cell viability and nuclear condensation/fragmentation. Flow cytometry accounted for more number of cells in G0/G1 phase and an increase in total number of early apoptotic cells (39.5%). Overall, this study is the first to report on apoptotic property of cyanobacterial phycoerythrin from marine Lyngbya sp. A09DM against A549 human lung carcinoma cells and requires a detailed scrutiny to establish its anti-cancer potential. Article Info

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Cytotoxicity evaluation and antimicrobial studies of starch capped water soluble copper nanoparticles

Cited by 130 publications

References 30 publications

Antibacterial Activity of Nanocomposites of Copper and Cellulose

Antibacterial Activity of Nanocomposites of Copper and Cellulose

Synthesis and Bactericidal Properties of Hyaluronic Acid Doped with Metal Nanoparticles

Cyanobacterial phycoerythrin purified from marine <i>Lyngbya</i> sp. induces apoptosis in lung carcinoma cells

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