“…Cytotoxicity results showed that Ca(OH) 2 resulted in less cell viability at a concentration of 160 mg mL −1 and higher due to high pH and hydroxyl ions. 45 Contrarily, MCSN possessed lower cytotoxicity in vitro in the studied dosage range and induced ≤15% HDPC death even when the concentration reached the highest of 640 mg mL −1 . But when loaded with CHX, MCSN induced severe cell death when the concentration of 2%CHX–MCSN was up to 320 μg mL −1 .…”
MCSNs could be used as a promising biomaterial for occluding the dentinal tubules in vitro and in vivo. Also, the outstanding drug delivery and antibacterial properties enable it to carry antibiotics easily for inhibiting deeper pulp infection.
“…Cytotoxicity results showed that Ca(OH) 2 resulted in less cell viability at a concentration of 160 mg mL −1 and higher due to high pH and hydroxyl ions. 45 Contrarily, MCSN possessed lower cytotoxicity in vitro in the studied dosage range and induced ≤15% HDPC death even when the concentration reached the highest of 640 mg mL −1 . But when loaded with CHX, MCSN induced severe cell death when the concentration of 2%CHX–MCSN was up to 320 μg mL −1 .…”
MCSNs could be used as a promising biomaterial for occluding the dentinal tubules in vitro and in vivo. Also, the outstanding drug delivery and antibacterial properties enable it to carry antibiotics easily for inhibiting deeper pulp infection.
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