2017
DOI: 10.2147/ijn.s139004
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Cytotoxicity induced by carbon nanotubes in experimental malignant glioma

Abstract: Despite multiple advances in the diagnosis of brain tumors, there is no effective treatment for glioblastoma. Multiwalled carbon nanotubes (MWCNTs), which were previously used as a diagnostic and drug delivery tool, have now been explored as a possible therapy against neoplasms. However, although the toxicity profile of nanotubes is dependent on the physicochemical characteristics of specific particles, there are no studies exploring how the effectivity of the carbon nanotubes (CNTs) is affected by different m… Show more

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Cited by 31 publications
(14 citation statements)
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“…Some studies in animal models should be performed to corroborate the induction of no relevant toxicity in the brain tissue from the N-CNSs. However, it is possible that carbon nanomaterials within the brain tissue cannot degrade and can remain at the implant site without being naturally eliminated, as we have observed in previous studies with other MWCNTs [ 21 ]. Nevertheless, N-CNSs have additional advantages with respect to the MWCNTs, as N-CNSs have presented high biocompatibilities that allow them to function as scaffolding for fibroblast growth, allowing brain plasticity [ 22 ].…”
Section: Discussionmentioning
confidence: 97%
“…Some studies in animal models should be performed to corroborate the induction of no relevant toxicity in the brain tissue from the N-CNSs. However, it is possible that carbon nanomaterials within the brain tissue cannot degrade and can remain at the implant site without being naturally eliminated, as we have observed in previous studies with other MWCNTs [ 21 ]. Nevertheless, N-CNSs have additional advantages with respect to the MWCNTs, as N-CNSs have presented high biocompatibilities that allow them to function as scaffolding for fibroblast growth, allowing brain plasticity [ 22 ].…”
Section: Discussionmentioning
confidence: 97%
“…Previous studies have found the critical role of CNTs as an important carrier for the treatment of cancers. It has been reported that CNTs induce an inhibitory effect on the viability of malignant glioma cells [ 31 ]. CNTs handle the perturbing calcium to promote cancer cell apoptosis via low-intensity nanosecond electric pulse [ 32 ].…”
Section: Discussionmentioning
confidence: 99%
“…By modified with functionalized groups and polymers on surface, CNTs garnered superior properties such as hydrophilicity, biocompatibility and specificity. Samuel et al [ 24 ] designed chemical functionalized nitrogen-doped MWCNT by acid treatment. The products N-MWCNT-ox specifically eliminated RG2 cells through DNA damage and oxidative stress without inducing reactive inflammation or systemic toxicity.…”
Section: Carbon Allotropesmentioning
confidence: 99%