Cytotoxicity, Mutagenicity and Antimicrobial Activity of Forty Jordanian Medicinal Plants

Alkofahi, Ahmad S.; Abdelaziz, Ahmad; Mahmoud, Ibrahim I.; Abuirjie, Mustafa; Hunaiti, Abdelrahim A.; El-Oqla, Ahmad

doi:10.3109/13880209009082798

Cited by 26 publications

(10 citation statements)

References 5 publications

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“…The development of drug resistance in human pathogens against commonly used antibiotics has necessitated a search for new antimicrobial substances from other sources including plants. Plants are known to produce a variety of compounds to protect them-selves against a variety of their own pathogens and therefore can be considered as potential source of different classes of antimicrobial substances (Alamagboul et al, 1985;Alkofahi et al, 1990;Grayer & Harborne, 1994;Olukoya et al, 1993).…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Activity of Jordanian Medicinal Plants

Nimri

Meqdam

Alkofahi

1999

Pharmaceutical Biology

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The antibacterial activity of ethanol extracts of 15 plant species used in the traditional medicine in Jordan and other Middle East countries were tested. Extracts of certain parts of these plants were tested in vitro against 14 pathogenic bacterial species and strains using the agar diffusion method. Results evaluated as the diameter of inhibition zone of bacterial growth showed that 25 mg/well of 12 plant extracts have antibacterial activity on one or more of the tested bacteria. Three plants exhibited broad spectrum antibacterial activity: Punica granatum L., Quercus infectoria Olive., and Rhus coriaria L. The most susceptible bacteria were Pseudomonas aeruginosa, Bacillus cereus and Streptococcus pyogenes (ATCC 12351), and the most resistant species were Escherichia coli (ATCC 25922 and clinical isolates), Klebsiella pneumoniae, Shigella dysentriae (ATCC 49345), and Yersinia enterocolitica (ATCC 9610). The minimum inhibitory concentrations (MIC) of active extracts ranged from 4-32 mg/ml while the minimum bactericidal concentrations (MBC) were exerted at higher doses 8-62 mg/ml.

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Section: Introductionmentioning

confidence: 99%

Antibacterial Activity of Jordanian Medicinal Plants

Nimri

Meqdam

Alkofahi

1999

Pharmaceutical Biology

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“…This kind of significant activity might be due to active compounds such as menthol, menthone, menthyl acetate, menthofuran, and limnone (Fleming, 1998). These compounds have higher medicinal value especially in the treatment of dyspepsia, epigastric bloating, impaired digestion, eructions, and flatulence, tropically used to relieve nasal congestion in the common cold and itch relieving used as tropic protective agents (Alkofahi et al, 1990). The antibacterial activity was expressed at varying degrees relying on both strain and dosage.…”

Section: Discussionmentioning

confidence: 99%

Antibacterial activity of Mentha piperita against selected food spoiling bacteria

Al-Dhabi¹,

Rajaram²,

Muthukumar³

et al. 2012

Afr. J. Biotechnol.

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Leaf and stem extracts of Mentha piperita plant were tested against four bacterial isolates namely: Bacillus sp. (S1), Bacillus sp. (S2), Bacillus halmapalus and Streptomyces sodiphilus, isolated from commercial Spirulina products. The extraction was carried out with solvents such as petroleum ether, acetone, methanol and ethanol. Antibacterial assay revealed that B. halmapalus was highly sensitive to both leaf and stem extracts. Bacillus sp. (S2) and S. sodiphilus was moderately sensitive to all extracts.

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“…The extraction was prepared by Abdelaziz et al [11] and Holopainen et al [12]. Dried spices and medical herbs were extracted with acetone at room temperature.…”

Section: Preparation Of Extractmentioning

confidence: 99%

Antibacterial and antifungal effects of acetone extracts from fifty spice and herb plants

Demirkol

Ertürk

2019

Herba Polonica

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Introduction: Chemical industry is obligatory to improve new chemically effective components. Spices are potential new antimicrobials.Objective: The present study was designed to evaluate the antibacterial and antifungal activity of fifty aromatic spices and medicinal herbs obtained from Turkey. Material and methods:In vitro antibacterial activities of a total of fifty acetone extracts from aromatic spices and medicinal herbs were studied by disc diffusion and agar diffusion method. The extracts were tested against three Gram-positive bacteria (Listeria monocytogenes, Staphylococcus aureus, Bacillus cereus), four Gram-negative bacteria (Proteus vulgaris, Escherichia coli, Pseudomonas aeruginosa, Salmonella typhimurium) and two fungi (Aspergillus niger, Candida albicans).Results: The highest antimicrobial activity was observed in the extract of Alpinia officinarum against Salmonella typhimurium and Cassia angustifolia against Bacillus cereus. Many of the extracts showed minimum inhibition concentration at even lowest dose. Conclusion:The obtained results showed that aromatic spices and medicinal herbs may be used as natural antimicrobials against diseases.Antibacterial activity was determined in acetone extracts with disc diffusion method [13]. Inhibition zones were evaluated after the incubation in 37°C for 24 h. All tests were performed in triplicate. Ampicillin and cefazolin were used for positive control, yet acetone as negative control. Antifungal assayAntifungal activity was determined in acetone extracts with disc diffusion method [13].

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Cytotoxicity, Mutagenicity and Antimicrobial Activity of Forty Jordanian Medicinal Plants

Cited by 26 publications

References 5 publications

Antibacterial Activity of Jordanian Medicinal Plants

Antibacterial Activity of Jordanian Medicinal Plants

Antibacterial activity of Mentha piperita against selected food spoiling bacteria

Antibacterial and antifungal effects of acetone extracts from fifty spice and herb plants

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