Cytotoxicity of Bismuth Compounds to Cultured Cancer Cells

Kobayashi, Jun; Ikeda, Keiichi; Sugiyama, Hideo

doi:10.4172/2161-0525.1000462

Cited by 2 publications

(4 citation statements)

References 5 publications

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“…The oral 50% lethal dose (L D50 ) of BiCl 3 for rats is 3334 mg/kg [ 35 ], which is lower than those of Bu 2 SnO (500 mg/kg) [ 36 ] BaO (418 mg/kg) [ 37 ], zinc acetate (664 mg/kg) [ 38 ], and even NaCl (3000 mg/kg) [ 39 ], Ti(OBu) 4 (3122 mg/kg) [ 40 ] and Ti(OPr i ) 4 (7236 mg/kg) [ 41 ]. In addition, BiCl 3 does not exhibit cytotoxicity in human thyroid cancer cells and mitigates the cytotoxicity of gallic acid, probably by complexation [ 28 ]. To the best of our knowledge, the toxicity of BiBr 3 has not been reported.…”

Section: Resultsmentioning

confidence: 99%

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Non-Isocyanate Synthesis of Aliphatic Polyurethane by BiCl3-Catalyzed Transurethanization Polycondensation

Ochiai,

Kobayashi

2024

Polymers

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Non-isocyanate polyurethane synthesis by non-Sn catalysis is an essential challenge toward green polyurethane synthesis. Bismuth compounds are attractive candidates due to their low cost, low toxicity, and availability to urethane chemistry. This work applied various Bi catalysts to the self-polycondensation of a bishydroxyurethane monomer and found BiCl3 to be an excellent catalyst through optimization. The catalytic activity and price of BiCl3 are comparable to those of Bu2SnO, while its toxicity is significantly low. BiCl3 is, therefore, a promising alternative to Sn-based catalysts in non-isocyanate polyurethane synthesis.

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Section: Resultsmentioning

confidence: 99%

“…For an exploration of new catalysts, we focused on compounds of bismuth, which is an inexpensive and safe heavy element [ 26 , 27 , 28 , 29 ]. Many organic and inorganic bismuth compounds have very low toxicity, and some bismuth salts are applied as stomach medicines.…”

Section: Introductionmentioning

confidence: 99%

Non-Isocyanate Synthesis of Aliphatic Polyurethane by BiCl3-Catalyzed Transurethanization Polycondensation

Ochiai,

Kobayashi

2024

Polymers

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“…The cytotoxicity of common bismuth compounds in human thyroid cancer cells was also investigated by Kobayashi et al The compounds tested included bismuth acetate, bismuth chloride, bismuth subgallate, and bismuth subsalicylate. These authors found some cytotoxicity only in the cells treated with bismuth subgallate [72].…”

Section: Antitumor Effectsmentioning

confidence: 93%

“…The following supporting information can be downloaded at: https: //www.mdpi.com/article/10.3390/ijms25031600/s1. References [30,35,[44][45][46][47][48][50][51][52][53][54][55][56][57][58][60][61][62][63][65][66][67][68][69][70][72][73][74][75]85] are cited in the supplementary materials.…”

Section: Supplementary Materialsmentioning

confidence: 99%

Bioactive Bismuth Compounds: Is Their Toxicity a Barrier to Therapeutic Use?

Gonçalves,

Matias,

Salvador

et al. 2024

IJMS

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Bismuth compounds are considered relatively non-toxic, with their low solubility in aqueous solutions (e.g., biological fluids) being the major contributing factor to this property. Bismuth derivatives are widely used for the treatment of peptic ulcers, functional dyspepsia, and chronic gastritis. Moreover, the properties of bismuth compounds have also been extensively explored in two main fields of action: antimicrobial and anticancer. Despite the clinical interest of bismuth-based drugs, several side effects have also been reported. In fact, excessive acute ingestion of bismuth, or abuse for an extended period of time, can lead to toxicity. However, evidence has demonstrated that the discontinuation of these compounds usually reverses their toxic effects. Notwithstanding, the continuously growing use of bismuth products suggests that it is indeed part of our environment and our daily lives, which urges a more in-depth review and investigation into its possible undesired activities. Therefore, this review aims to update the pharmaco-toxicological properties of bismuth compounds. A special focus will be given to in vitro, in vivo, and clinical studies exploring their toxicity.

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Cytotoxicity of Bismuth Compounds to Cultured Cancer Cells

Cited by 2 publications

References 5 publications

Non-Isocyanate Synthesis of Aliphatic Polyurethane by BiCl3-Catalyzed Transurethanization Polycondensation

Non-Isocyanate Synthesis of Aliphatic Polyurethane by BiCl3-Catalyzed Transurethanization Polycondensation

Bioactive Bismuth Compounds: Is Their Toxicity a Barrier to Therapeutic Use?

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