Cytotoxicity of botanicals and isolated phytochemicals from Araliopsis soyauxii Engl. (Rutaceae) towards a panel of human cancer cells

Mbaveng, Armelle T.; Noulala, Cédric Guy Tchatchouang; Samba, Anne R.M.; Tankeo, Simplice B.; Fotso, Ghislain Wabo; Happi, Emmanuel Ngeufa; Ngadjui, Bonaventure T.; Beng, Véronique Penlap; Kuete, Victor; Efferth, Thomas

doi:10.1016/j.jep.2020.113535

Cited by 15 publications

(9 citation statements)

References 55 publications

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“…They are involved in apoptosis by secreting pro-apoptotic proteins that respond to chemical stimuli. 47 The health of mitochondria can be assessed by measuring the mitochondrial membrane potential (MMP). It is interesting to note that MMP depletion connects with ROS generation.…”

Section: Resultsmentioning

confidence: 99%

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Fabrication of myristic acid–potato starch complex nanostructures and assessment of their cytotoxic behavior

Almushawah,

Athinarayanan,

Periasamy

et al. 2023

J Sci Food Agric

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BACKGROUNDLipids and carbohydrates play essential functions in foods. In the last few decades, food scientists have studied the effects of carbohydrate‐lipid interaction on food's functional properties. However, how carbohydrate‐lipid complex‐derived materials affect the biological system is unknown. We created a myristic acid‐potato starch complex using a simple cooking approach. The complex was employed as a precursor for myristic acid‐potato starch complex‐based nanostructured materials (MPS‐NMs) fabrication through a liquid‐liquid extraction approach. A study was conducted on the structural and cytotoxic features of fabricated MPS‐NMs.RESULTSThe transmission electron microscopy images confirm spherical nanostructure formation with 3 ‐ 60 nm in size. After 24 h exposure, the chloroform fraction‐ and n‐hexane fraction‐based MPS‐NMs enhanced cell death by ~ 90% and ~ 82%, respectively. The chloroform fraction‐based MPS‐NMs (CMPS‐NMs) triggers apoptotic cell death in human mesenchymal stem cells (hMSCs). Also, n‐hexane fraction‐based MPS‐NMs (HMPS‐NMs) treated cells have red colour‐intact nuclei, attributed to necrotic cell death. CMPS‐NMs and HMPS‐NMs significantly decreased the mitochondria membrane potential and increased intracellular ROS levels. We observed significant downregulation in FMO, ATM and UGT gene expression levels in the exposed cells of CMPS‐NMs and HMPS‐ NMs. In addition, GSR and GSTA4 genes have upregulation in CMPS‐NMs and HMPS‐ NMs exposure.CONCLUSIONOur results conclude that the cooking process may lead to the formation of nanostructured material in food systems. These CMPS‐NMs and HMPS‐NMs may also contribute to cell metabolic disorders.This article is protected by copyright. All rights reserved.

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Section: Resultsmentioning

confidence: 99%

“…Mitochondria play a crucial role in the regulation of cell respiration and metabolism. They are involved in apoptosis by secreting pro‐apoptotic proteins that respond to chemical stimuli 47 . The health of mitochondria can be assessed by measuring the mitochondrial membrane potential (MMP).…”

Section: Resultsmentioning

confidence: 99%

Fabrication of myristic acid–potato starch complex nanostructures and assessment of their cytotoxic behavior

Almushawah,

Athinarayanan,

Periasamy

et al. 2023

J Sci Food Agric

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“…and both characterized as anticancer agents capable of inhibiting the growth of various tumor cell lines in vitro. [ 63 ] It will be interesting to examine more closely the potential contribution of GSK‐3β inhibition to the anticancer activity. Nomilin ( 7 ) and kihadanin B ( 9 ) emerge as potential GSK‐3β ligands.…”

Section: Resultsmentioning

confidence: 99%

Molecular docking study of GSK‐3β interaction with nomilin, kihadanin B, and related limonoids and triterpenes with a furyl‐δ‐lactone core

Vergoten

Bailly

2022

J Biochem & Molecular Tox

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Glycogen synthase kinase‐3β (GSK‐3β) is a target enzyme considered for the treatment of multiple human diseases, from neurodegenerative pathologies to viral infections and cancers. Numerous inhibitors of GSK‐3β have been discovered but thus far only a few have reached clinical trials and only one drug, tideglusib (1), has been registered. Natural products targeting GSK‐3β have been identified, including the two anticancer limonoids obacunone (5) and gedunin (4), both presenting a furyl‐δ‐lactone core. To help identifying novel GSK‐3β ligands, we have performed a molecular docking study with 15 complementary natural products bearing a furyl‐δ‐lactone unit (such as limonin (6) and kihadanins A (8) and B (9)) or a closely related structure (such as cedrelone (10) and nimbolide (11)). The formation of GSK‐3β‐binding complexes for those natural products was compared to reference GSK‐3β ATP‐competitive inhibitors LY2090314 (3) and AR‐A014418 (2). Our in silico analysis led to the identification of two new GSK‐3β‐binding natural products: kihadanin B (9) and nomilin (7). The latter surpassed the reference compounds in terms of calculated empirical energy of interaction (ΔE). Nomilin (7) can possibly bind to the active site of GSK‐3β, notably via the furyl‐δ‐lactone core and its 1‐acetyl group, implicated in the protein interaction. Compound structure‐binding relationships are discussed. The study should help the discovery of novel natural products targeting GSK‐3β.

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“…In addition, cell cycle arrest was noted by several studies, at different stages of the cell cycle, with G2/M arrest [134,142,153,162,164], being most commonly noted, followed by Sub-G0 [133,135,156] and G0/G1 arrest [140,142]. A considerable number of the included studies (9/36) observed that extracts and phytochemicals induced cell death by generating ROS low concentrations [130,131,140,142,143,147,154,159]. This suggests that the generation of ROS may be a promising therapeutic strategy against GBM.…”

Section: Natural Extract and Phytochemical Efficacy Against Glioblast...mentioning

confidence: 99%

Glioblastoma Multiforme: Molecular Biology and Updated Systematic Review on Natural Extract and Phytochemical Efficacy In-vitro

Cuschieri

Baron

2023

JOCAMR

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Glioblastoma multiforme (GBM) is the most prevalent primary malignant central nervous system tumours (CNST). Current treatment consists of surgical resection and adjuvant chemoradiotherapy, the gold-standard agent being Temozolomide (TMZ). Despite optimal treatment, GBM has an abysmal associated prognosis of approximately 15 months. The disproportionately high morbidity and mortality necessitate studies which strive to increase knowledge on putative therapeutic agents to confirm or deny their possible use against GBM Therefore, there is an urgent need to develop a deep understanding of GBM molecular biology upon which more effective therapeutic strategies may be developed. Natural extracts and phytochemicals have shown promise as potential therapeutic agents against GBM. In this review, the molecular biology of GBM and molecular factors which contribute to therapeutic resistance are discussed in depth. The mechanisms by which phytochemicals and natural extracts exhibit can inhibit GBM growth and proliferation are discussed. Moreover, statistical analysis demonstrated that natural extracts and phytochemicals may be superior to TMZ in-vitro. This review demonstrates that phytochemicals have great potential as novel therapeutic agents against GBM. Further preclinical and clinical studies are needed to determine the optimal doses, routes of administration, and potential toxicities of these agents, but their unique molecular targets and low toxicity profiles make them attractive candidates for further investigation.

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Cytotoxicity of botanicals and isolated phytochemicals from Araliopsis soyauxii Engl. (Rutaceae) towards a panel of human cancer cells

Cited by 15 publications

References 55 publications

Fabrication of myristic acid–potato starch complex nanostructures and assessment of their cytotoxic behavior

Fabrication of myristic acid–potato starch complex nanostructures and assessment of their cytotoxic behavior

Molecular docking study of GSK‐3β interaction with nomilin, kihadanin B, and related limonoids and triterpenes with a furyl‐δ‐lactone core

Glioblastoma Multiforme: Molecular Biology and Updated Systematic Review on Natural Extract and Phytochemical Efficacy In-vitro

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