Cytotoxicity of Heavy Metals to A Thyroid Carcinoma Cell Line

Kobayashi, Jun; Ikeda, Keiichi; Sugiyama, Hideo

doi:10.4172/2161-0525.1000461

Cited by 5 publications

(5 citation statements)

References 8 publications

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“…A consensus, among these studies, is that the mitochondria are a vital organelle in mediating Cd-related toxicities. In vitro studies with the ‘8505C’ thyroid cell line have demonstrated Cd-induced toxicity at relatively low Cd concentrations [ 73 , 74 ]. Observed toxicity was reversed when cell media was supplemented with either calcium or selenium, suggesting interference with Cd uptake.…”

Section: Mechanisms Of Cadmium Thyrotoxicitymentioning

confidence: 99%

Overview of Cadmium Thyroid Disrupting Effects and Mechanisms

Buha

Matović

Antonijević

et al. 2018

IJMS

165

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Humans are exposed to a significant number of chemicals that are suspected to produce disturbances in hormone homeostasis. Hence, in recent decades, there has been a growing interest in endocrine disruptive chemicals. One of the alleged thyroid disrupting substances is cadmium (Cd), a ubiquitous toxic metal shown to act as a thyroid disruptor and carcinogen in both animals and humans. Multiple PubMed searches with core keywords were performed to identify and evaluate appropriate studies which revealed literature suggesting evidence for the link between exposure to Cd and histological and metabolic changes in the thyroid gland. Furthermore, Cd influence on thyroid homeostasis at the peripheral level has also been hypothesized. Both in vivo and in vitro studies revealed that a Cd exposure at environmentally relevant concentrations results in biphasic Cd dose-thyroid response relationships. Development of thyroid tumors following exposure to Cd has been studied mainly using in vitro methodologies. In the thyroid, Cd has been shown to activate or stimulate the activity of various factors, leading to increased cell proliferation and a reduction in normal apoptotic activity. Evidence establishing the association between Cd and thyroid disruption remains ambiguous, with further studies needed to elucidate the issue and improve our understanding of Cd-mediated effects on the thyroid gland.

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Section: Mechanisms Of Cadmium Thyrotoxicitymentioning

confidence: 99%

Overview of Cadmium Thyroid Disrupting Effects and Mechanisms

Buha

Matović

Antonijević

et al. 2018

IJMS

165

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“…Several toxic trace metals, primarily cadmium (Cd), arsenic (As), lead (Pb), and mercury (Hg), could be associated with the etiology of TC. Cd inhibits the activity of antioxidative enzymes and induces oxidative stress, impairs mitochondria, depletes DNA repair mechanisms, reduces apoptosis, activates ERK (extracellular signal-regulated kinase), PI3K (phosphoinositide 3-kinase), and signaling pathways, and promotes initiation and progression of the malignant process (Kobayashi et al 2017;Huff et al 2007;Alkharashi et al 2017;Buha et al 2018;Ferrari et al 2017). Cancer progression and gain of metastatic growth result from the Cd-mediated disruption effect on the cellular adhesion molecule, E-cadherin that favors tumor invasion dissemination (Prozialeck et al 2003).…”

Section: Trace Metals and Thyroid Cancermentioning

confidence: 99%

“…Several studies have highlighted the impact of Cd on TC. An in vitro study conducted by Kobayashi et al (2017) reported the cytotoxicity of 12 trace metals on a TC cell line. Although the authors noted reduced cell viability with Ni 2+ , Cu 2+ , and Zn 2+ , the effects of Cd 2+ on cell death were most pronounced.…”

Section: Cadmium and Thyroid Cancermentioning

confidence: 99%

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Impact of Essential and Toxic Trace Metals on Thyroid Health and Cancer: A Review

Stojsavljević

Rovčanin

2021

Expo Health

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Most investigations conducted in the last four decades have shown a rising incidence of thyroid diseases worldwide. Although our knowledge of the molecular pathways of thyroid disease has advanced, the initial steps in thyroid cancerogenesis have not yet been sufficiently elucidated. However, recent human biomonitoring studies have shown that specific trace metals, as major endocrine disrupters, could be considered as risk factors for impaired thyroid health and the evolution of thyroid cancer (TC). In this review, the impact of essential and toxic trace metals from the environment on thyroid health and TC was evaluated. Furthermore, this review clarifies which trace metals most likely contribute to the etiology of TC. Biomarkers based on trace metal ratios are proposed. Overall, the information described in this review is expected to be useful in planning future fundamental and applied studies on the endocrine toxicity of essential and toxic trace metals.

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“…Although Cd thyrotoxicosis has been widely documented, most works have focused on thyroid hormone function, yielding conflicting data [4,5]. Few studies have investigated the action of Cd on human thyroid cells and the underlying molecular and cellular mechanisms involved in thyroid toxicity, and most studies have been performed in cancer cell lines [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Quercetin Protects Human Thyroid Cells against Cadmium Toxicity

Capriglione

Maiuolo

Celano

et al. 2021

IJMS

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Various natural compounds have been successfully tested for preventing or counteracting the toxic effects of exposure to heavy metals. In this study, we analyzed the effects of cadmium chloride (CdCl2) on immortalized, non-tumorigenic thyroid cells Nthy-ori-3-1. We investigated the molecular mechanism underlying its toxic action as well as the potential protective effect of quercetin against CdCl2-induced damage. CdCl2 suppressed cell growth in a dose- and time-dependent manner (IC50 value ~10 μM) associated with a decrease in levels of phospho-ERK. In addition, CdCl2 elicited an increase in reactive oxygen species (ROS) production and lipid peroxidation. A significant increase in GRP78, an endoplasmic reticulum (ER) stress-related protein, was also observed. Supplementation of quercetin counteracted the growth-inhibiting action of CdCl2 by recovering ERK protein phosphorylation levels, attenuating ROS overproduction, decreasing MDA content and reducing the expression of GRP78 in cells exposed to CdCl2. Thus, in addition to revealing the molecular effects involved in cadmium-induced toxicity, the present study demonstrated, for the first time, a protective effect of quercetin against cadmium-induced damages to normal thyroid cells.

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Cytotoxicity of Heavy Metals to A Thyroid Carcinoma Cell Line

Cited by 5 publications

References 8 publications

Overview of Cadmium Thyroid Disrupting Effects and Mechanisms

Overview of Cadmium Thyroid Disrupting Effects and Mechanisms

Impact of Essential and Toxic Trace Metals on Thyroid Health and Cancer: A Review

Quercetin Protects Human Thyroid Cells against Cadmium Toxicity

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