Cytotoxicity of lanostane-type triterpenoids and ergosteroids isolated from Omphalia lapidescens on MDA-MB-231 and HGC-27 cells

Liu, Fei; Chen, Jinfeng; Wang, Yue; Guo, Li; Zhou, Qin‐Mei; Peng, Cheng; Xiong, Liang

doi:10.1016/j.biopha.2019.109273

Cited by 10 publications

(2 citation statements)

References 31 publications

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“…The cytotoxic activity of the isolates against the MCF-7 and MDA-MB-231 human breast cancer cells were determined by a colorimetric MTT assay, as described in the literature [9,28]. Paclitaxel was used as a positive control.…”

Section: Methodsmentioning

confidence: 99%

New Isoflavanes from Spatholobus suberectus and Their Cytotoxicity against Human Breast Cancer Cell Lines

et al. 2019

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The rattans of Spatholobus suberectus Dunn are a traditional Chinese medicine activating blood circulation and removing stasis. They have often been used for the traditional Chinese medicinal treatment of breast cancer in modern China. In this study, four novel isoflavanes (1–3 and 5) and four known analogues (4 and 6–8) were isolated from an ethanolic extract of the rattans of S. suberectus. Their structures were elucidated by extensive spectroscopic analyses and electronic circular dichroism studies. MCF-7 and MDA-MB-231 human breast cancer cell lines were used to evaluate the cytotoxic effects of the isolates. Interestingly, compounds 1 and 2 only inhibited the proliferation of MCF-7 cells, while compound 6 showed a selective cytotoxicity against MDA-MB-231 cells. However, compound 4 had significant cytotoxicity against both MCF-7 and MDA-MB-231 cell lines.

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Section: Methodsmentioning

confidence: 99%

New Isoflavanes from Spatholobus suberectus and Their Cytotoxicity against Human Breast Cancer Cell Lines

et al. 2019

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“…The latter is the main sterol of fungi involved in the regulation of membrane fluidity and structure as well as performing immunological functions [ 4 ]. Fungal ergosterol derivatives are often referred to as “ergostane-type steroids” [ 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 ] or “ergosteroids” [ 13 , 14 , 15 , 16 , 17 ]. One should bear in mind, however, that the application of the term “ergosteroids” can be confusing, as it was also suggested by Lardy et al [ 18 ] to structurally different dehydroepiandrosterone derivatives based on their mode of action (influence on energy metabolism).…”

Section: Introductionmentioning

confidence: 99%

Structure and Biological Activity of Ergostane-Type Steroids from Fungi

2022

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Mushrooms are known not only for their taste but also for beneficial effects on health attributed to plethora of constituents. All mushrooms belong to the kingdom of fungi, which also includes yeasts and molds. Each year, hundreds of new metabolites of the main fungal sterol, ergosterol, are isolated from fungal sources. As a rule, further testing is carried out for their biological effects, and many of the isolated compounds exhibit one or another activity. This study aims to review recent literature (mainly over the past 10 years, selected older works are discussed for consistency purposes) on the structures and bioactivities of fungal metabolites of ergosterol. The review is not exhaustive in its coverage of structures found in fungi. Rather, it focuses solely on discussing compounds that have shown some biological activity with potential pharmacological utility.

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Unveiling the pharmacological potential of plant triterpenoids in breast cancer management: an updated review

Aly,

Elbadry,

Doghish

et al. 2024

Naunyn-Schmiedeberg's Arch Pharmacol

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Breast cancer is the most prevalent type of cancer, the fifth leading cause of cancer-related deaths, and the second leading cause of cancer deaths among women globally. Recent research has provided increasing support for the significance of phytochemicals, both dietary and non-dietary, particularly triterpenoids, in the mitigation and management of breast cancer. Recent studies showed that triterpenoids are promising agents in the treatment and inhibition of breast cancer achieved through the implementation of several molecular modes of action on breast cancer cells. This review discusses recent innovations in plant triterpenoids and their underlying mechanisms of action in combating breast cancer within the timeframe spanning from 2017 to 2023. The present work is an overview of different plant triterpenoids with significant inhibition on proliferation, migration, apoptosis resistance, tumor angiogenesis, or metastasis in various breast cancer cells. The anticancer impact of triterpenoids may be attributed to their antiproliferative activity interfering with angiogenesis and differentiation, regulation of apoptosis, DNA polymerase inhibition, change in signal transductions, and impeding metastasis. The present review focuses on several targets, mechanisms, and pathways associated with pentacyclic triterpenoids, which are responsible for their anticancer effects. We could conclude that natural triterpenoids are considered promising agents to conquer breast cancer. Graphical Abstract

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Cytotoxicity of lanostane-type triterpenoids and ergosteroids isolated from Omphalia lapidescens on MDA-MB-231 and HGC-27 cells

Cited by 10 publications

References 31 publications

New Isoflavanes from Spatholobus suberectus and Their Cytotoxicity against Human Breast Cancer Cell Lines

New Isoflavanes from Spatholobus suberectus and Their Cytotoxicity against Human Breast Cancer Cell Lines

Structure and Biological Activity of Ergostane-Type Steroids from Fungi

Unveiling the pharmacological potential of plant triterpenoids in breast cancer management: an updated review

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