Cytotoxicity of lymphoid cells induced by Maclura pomifera (MP) lectin

Jones, Joe M.; Soderberg, Frances B.

doi:10.1016/0008-8749(79)90197-7

Cited by 9 publications

(6 citation statements)

References 16 publications

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“…Maclura aurantiaca is used for cardiovascular ailments in Azerbaijan (Yakupoglu and Adisoglu, 1991). Several biological activities of Maclura pomifera and its components including antibacterial, antifungal, antiviral, cytotoxic, antitumor, estrogenic and antimalarial activities have been so far reported (Peterson and Brockemeyer, 1953;Jones and Soderberg, 1979;Mahmoud, 1981;Voynova et al, 1991;Maier et al, 1995;Bunyapraphatsara et al, 2000;Hay et al, 2004). Besides, various phytochemical studies carried out on Maclura pomifera showing that the plant contains lectins, triterpenes, xanthones and flavone-type compounds (Wagner and Harris, 1952;Ulevitch et al, 1974;Gearien and Klein, 1975;Gerber, 1986;Young et al, 1991Young et al, , 1995Lee et al, 1998;Marek et al, 2003).…”

Section: Introductionmentioning

confidence: 93%

Anti-inflammatory and antinociceptive potential of Maclura pomifera (Rafin.) Schneider fruit extracts and its major isoflavonoids, scandenone and auriculasin

Küpeli

Orhan

Toker

et al. 2006

Journal of Ethnopharmacology

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Section: Introductionmentioning

confidence: 93%

Anti-inflammatory and antinociceptive potential of Maclura pomifera (Rafin.) Schneider fruit extracts and its major isoflavonoids, scandenone and auriculasin

Küpeli

Orhan

Toker

et al. 2006

Journal of Ethnopharmacology

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“…Some studies were conducted to utilize it for industrial use such as composites (Tisserat and Harry‐O'kuru, 2019). Extracts from fruit and other parts of the tree are of great interest due to biological activities such as anti‐inflammatory and antinociceptive (Kupeli et al, 2006), antifungal (Peterson and Brockemeyer, 1953), cytotoxic (Jones and Soderberg, 1979), antimicrobial (Mahmoud, 1981), anti‐tumor (Voynova et al, 1991), estrogenic (Maier et al, 1995), antiviral (Bunyapraphatsara et al, 2000), and antimalarial activities (Hay et al, 2004). Among a variety of phytochemicals found in the Osage orange fruit, the bioactivities of two major isoflavones, osajin, and pomiferin, have been intensely studied.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Activity of Osage Orange Extract in Soybean Oil and Fish Oil during Storage

Hwang

Winkler‐Moser

Tisserat

et al. 2020

J Americ Oil Chem Soc

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The food industry is seeking natural antioxidants for edible oils that have comparable activity to synthetic counterparts. In this study, Osage orange extract (OOE) rich in osajin (42.9%) and pomiferin (30.0%) was obtained after hexane extraction of the fruit, and its antioxidant activity was examined in stripped soybean oil (SBO) and fish oil (FO), in which antioxidants and polar compounds were removed. The antioxidant activity of OOE was compared with commercial natural antioxidants (i.e., rosemary extract and mixed tocopherols) and a synthetic antioxidant, butylated hydroxytoluene (BHT), during storage at 25 and 40 °C. The 0.1% OOE had stronger antioxidant activity than 0.1% rosemary extract and 0.1% mixed tocopherols in both oils at 25 and 40 °C. Its activity was similar to 0.02% BHT in SBO and was similar or slightly stronger than 0.02% BHT in FO. When OOE was studied at 0.05, 0.1, and 0.2%, there was a weak dose–response in SBO but a stronger dose–response in FO. Headspace volatile analysis using solid phase micro‐extraction (SPME) combined with GC–MS indicated that 0.1% OOE was very effective in preventing the formation of volatile oxidation products in both oils. Although it should be further tested for safety before the actual use, this study shows that OOE can be developed as an antioxidant for edible oils.

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“…Worldwide, various Maclura species are used in folk medicine. Native Americans used M. pomifera for the treatment of cancer [ 2 ]. In Bolivia, the plant sap is used for the treatment of tooth pain, and the bark and leaves are used for uterine hemorrhage [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Isolation and Biological Evaluation of Prenylated Flavonoids from Maclura pomifera

Orazbekov

Ibrahim

Момбеков

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Phytochemical analysis of the ethanolic extract of Maclura pomifera fruits yielded four new compounds (I–IV) along with eleven known compounds (V–XV). The crude extract exhibited significant activity towards cannabinoid receptors (CB1: 103.4% displacement; CB2: 68.8% displacement) and possibly allosteric interaction with δ and μ opioid receptors (−49.7 and −53.8% displacement, resp.). Compound I was found to be possibly allosteric for κ and μ opioid receptors (−88.4 and −27.2% displacement, resp.) and showed moderate activity (60.5% displacement) towards CB1 receptor. Compound II exhibited moderate activity towards cannabinoid receptors CB1 and CB2 (47.9 and 42.3% displacement, resp.). The known compounds (V–VIII) exhibited prominent activity towards cannabinoid receptors: pomiferin (V) (IC50 of 2.110 and 1.318 μM for CB1 and CB2, resp.), auriculasin (VI) (IC50 of 8.923 μM for CB1), warangalone (VII) (IC50 of 1.670 and 4.438 μM for CB1 and CB2, resp.), and osajin (VIII) (IC50 of 3.859 and 7.646 μM for CB1 and CB2, resp.). The isolated compounds were also tested for inhibition of human monoamine oxidase-A and monoamine oxidase-B enzymes activities, where all the tested compounds showed fewer inhibitory effects on MAO-A compared to MAO-B activities: auriculasin (VI) (IC50 of 1.91 and 45.98 μM for MAO-B and MAO-A, resp.).

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Cytotoxicity of lymphoid cells induced by Maclura pomifera (MP) lectin

Cited by 9 publications

References 16 publications

Anti-inflammatory and antinociceptive potential of Maclura pomifera (Rafin.) Schneider fruit extracts and its major isoflavonoids, scandenone and auriculasin

Anti-inflammatory and antinociceptive potential of Maclura pomifera (Rafin.) Schneider fruit extracts and its major isoflavonoids, scandenone and auriculasin

Antioxidant Activity of Osage Orange Extract in Soybean Oil and Fish Oil during Storage

Isolation and Biological Evaluation of Prenylated Flavonoids from Maclura pomifera

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