Cytotoxicity of microglia

Bánati, Richard B.; Gw, Kreutzberg

doi:10.1016/0165-5728(92)90227-c

Cited by 247 publications

(290 citation statements)

References 8 publications

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“…Compartmental release of cytotoxic substances by activated macrophages potentially leads to further CNS damage. 12 In such cases, SPIO-endowed in vivo visualization of macrophage activity presents an exciting opportunity to monitor the real-time efficiency of therapeutic intervention. Clean delineation of metastases in the brain was possible through SPIO presence, initially, at the tumor interstitium and, subsequently, through uptake by surrounding tumor cells, approximately 24 h following injection.…”

Section: Macrophage Imagingmentioning

confidence: 99%

Superparamagnetic Iron Oxide Nanoparticle Probes for Molecular Imaging

et al. 2006

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Abstract-The field of molecular imaging has recently seen rapid advances in the development of novel contrast agents and the implementation of insightful approaches to monitor biological processes non-invasively. In particular, superparamagnetic iron oxide nanoparticles (SPIO) have demonstrated their utility as an important tool for enhancing magnetic resonance contrast, allowing researchers to monitor not only anatomical changes, but physiological and molecular changes as well. Applications have ranged from detecting inflammatory diseases via the accumulation of non-targeted SPIO in infiltrating macrophages to the specific identification of cell surface markers expressed on tumors. In this article, we attempt to illustrate the broad utility of SPIO in molecular imaging, including some of the recent developments, such as the transformation of SPIO into an activatable probe termed the magnetic relaxation switch.

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Section: Macrophage Imagingmentioning

confidence: 99%

Superparamagnetic Iron Oxide Nanoparticle Probes for Molecular Imaging

et al. 2006

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“…Tumor-associated microglia constitute the main population of brain immune cells (Graeber et al, 2002) and are important for monitoring their local environment, regulating function and apoptosis, and secreting proinflammatory cytokines (Banati et al, 1993;Elkabes et al, 1996;Marı´n-Teva et al, 2004;Roumier et al, 2004). These resident brain immune system mononuclear cells can be recruited by glioma tumors cells to the local tumor microenvironment by vascular Figure 3 Co-evolution of neoplastic and non-neoplastic cells in gliomas.…”

Section: Stromal Determinants Of Glioma Formation and Growthmentioning

confidence: 99%

The ecology of brain tumors: lessons learned from neurofibromatosis-1

Pong

Gutmann

2010

Oncogene

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Traditionally, cancer studies have primarily focused on mutations that activate growth or survival pathways in susceptible pre-neoplastic/neoplastic cells. However, recent research has revealed a critical role for nonneoplastic cells within the tumor microenvironment in the process of cancer formation and progression. In addition, the existence of regional and developmental variations in susceptible cell types and supportive microenvironments support a model of tumorigenesis in which the dynamic symbiotic relationship between neoplastic and non-neoplastic cell types dictate where and when cancers form and grow. In this review, we highlight advances in neurofibromatosis type 1 (NF1) genetically engineered mouse brain tumor (glioma) modeling to reveal how cellular and molecular heterogeneity in both the pre-neoplastic/ neoplastic and non-neoplastic cellular compartments contribute to gliomagenesis and glioma growth.

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“…This article refers only to the ®rst topic; readers interested in the biology of the adult microglia and their function in the normal and pathological brain should consult recent reviews (Perry and Gordon, 1991;Thomas, 1992;Banati et al, 1993;Banati and Graeber, 1994;Barron, 1995;Streit, 1995;Kreutzberg, 1996;Moore and Thanos, 1996).…”

Section: Introductionmentioning

confidence: 99%

The origin and differentiation of microglial cells during development

Cuadros

Navascués

1998

Progress in Neurobiology

269

177

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AbstractÐSome authors claim that microglia originate from the neuroepithelium, although most now believe that microglial cells are of mesodermal origin, and probably belong to the monocyte/macrophage cell line. These cells must enter the developing central nervous system (CNS) from the blood stream, the ventricular space or the meninges. Afterward microglial cells are distributed more or less homogeneously through the entire nervous parenchyma. Stereotyped patterns of migration have been recognized during development, in which long-distance tangential migration precedes radial migration of individual cells. Microglial cells moving through the nervous parenchyma are ameboid microglia, which apparently di erentiate into rami®ed microglia after reaching their de®nitive location. This is supported by the presence of cells showing intermediate features between those of ameboid and rami®ed microglia. The factors that control the invasion of the nervous parenchyma, migration within the developing CNS and di erentiation of microglial cells are not well known. These phenomena apparently depend on environmental factors such as soluble or cell-surface bound molecules and components of the extracellular matrix. Microglial cells within the developing CNS are involved in clearing cell debris and withdrawing misdirected or transitory axons, and presumably support cell survival and neurite growth. #

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Cytotoxicity of microglia

Cited by 247 publications

References 8 publications

Superparamagnetic Iron Oxide Nanoparticle Probes for Molecular Imaging

Superparamagnetic Iron Oxide Nanoparticle Probes for Molecular Imaging

The ecology of brain tumors: lessons learned from neurofibromatosis-1

The origin and differentiation of microglial cells during development

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