Cytotoxicity of Monensic Acid and its Biometal(II) Complexes Against Anaerobic Bacterial Strain<i>Clostridium Perfringens</i>Spp.

Zhorova, Rumyana; Marina, M.; Radeva, Antoaneta; Mitewa, M.; Pantcheva, Ivayla

doi:10.5504/bbeq.2013.0093

Cited by 3 publications

(3 citation statements)

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Section: Introductionmentioning

confidence: 99%

“…An overview of the published results on the activity of monensin and its complexes shows that they exhibit pronounced in vitro activity over some Gram-positive bacteria and human/animal tumor cell lines, incl. drug-resistant cells [38][39][40][41][42][43][44][45][46][47]. The studies on the biological activity of cerium(IV) reveal that CeO2 is a subject of interest in nano-scaled science due to its ability to form nano-sized particles which demonstrate potential to be applied in many scientific fields [48][49][50][51][52].…”

Section: Introductionmentioning

confidence: 99%

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Novel Cerium(IV) Coordination Compounds of Monensin and Salinomycin

et al. 2023

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The largely uncharted complexation chemistry of the veterinary polyether ionophores, monensic and salinomycinic acids (HL) with metal ions of type M4+ and the known antiproliferative potential of antibiotics has provoked our interest in exploring the coordination processes between MonH/SalH and ions of Ce4+. (1) Methods: Novel monensinate and salinomycinate cerium(IV)-based complexes were synthesized and structurally characterized by elemental analysis, a plethora of physicochemical methods, density functional theory, molecular dynamics, and biological assays. (2) Results: The formation of coordination species of a general composition [CeL2(OH)2] and [CeL(NO3)2(OH)], depending on reaction conditions, was proven both experimentally and theoretically. The metal(IV) complexes [CeL(NO3)2(OH)] possess promising cytotoxic activity against the human tumor uterine cervix (HeLa) cell line, being highly selective (non-tumor embryo Lep-3 vs. HeLa) compared to cisplatin, oxaliplatin, and epirubicin.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Novel Cerium(IV) Coordination Compounds of Monensin and Salinomycin

et al. 2023

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“…Monensic acid was found to be less active than metal complexes. The isostructural metal(II) compounds exert enhanced antitumor activity as compared to the noncoordinated ligand and their efficacy seems to depend both on the nature of the metal ions and on the cell lines tested [28][29][30].…”

Section: Introductionmentioning

confidence: 99%

Spectral properties and biological activity of La(III) and Nd(III) Monensinates

et al. 2019

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The present research is focused on evaluation of complexation ability of Monensic acid (MonH) towards La3+ and Nd3+ ions.Changes in the SRCD spectrum of Monensinate anion were monitored upon addition of lanthanide(III) ions. The antibiotic undergoes formation of one neutral ([Ln(Mon)3(H2O)3]) and two positively charged complex species of composition [Ln(Mon)2(H2O)2]+ and [Ln(Mon) (H2O)]2+, respectively (Ln = La3+, Nd3+). Neutral complexes were isolated as fine powders and were characterized by IR, FAB-MS and ESI-MS. It is assumed that Monensin acts in bidentate coordination mode via monodentate carboxylate moiety and hydroxyl group, both located at the opposite ends of antibiotic molecule.Activity of Monensic acid and [Ln(Mon)3(H2O)3] to decrease visible bacteria growth of B. subtilis, S. Lutea and B. mycoides was evaluated by agar hole diffusion method. Results showed that complexation of lanthanide(III) ions to Monensin enhances the activity of non-coordinated ligand.Antitumor efficacy of compounds was assayed on human triple negative breast cancer and transplantable sarcoma in rat. The cytotoxicity was accessed by MTT test, NR uptake, CV assay and double AO/PI staining. Experimental data revealed that Monensic acid and [Ln(Mon)3(H2O)3] possess concentration- and time-dependent activity, and express promising cytotoxic properties against human and rat permanent cancer cell lines.

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