Cytotoxicity of noble metal nanoparticles sputtered into glycerol

Staszek, Marek; Siegel, Jakub; Rimpelová, Silvie; Lyutakov, Oleksiy; Švorčı́k, Václav

doi:10.1016/j.matlet.2015.06.021

Cited by 34 publications

(24 citation statements)

References 21 publications

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“…The U-2 OS cellular line, however, exhibits a rather different behavior on the same substrate. For this cell line, both Pt and Pd are cytotoxic [119]. On the contrary, biocompatibility tests using the VSMC line on Au-grafted PE show that the PE functionalized by BPD-anchored Au nanoparticles has excellent properties for cell adhesion and proliferation [111].…”

Section: Nanoparticle Graftingmentioning

confidence: 99%

Surface Modification of Polymer Substrates for Biomedical Applications

2017

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While polymers are widely utilized materials in the biomedical industry, they are rarely used in an unmodified state. Some kind of a surface treatment is often necessary to achieve properties suitable for specific applications. There are multiple methods of surface treatment, each with their own pros and cons, such as plasma and laser treatment, UV lamp modification, etching, grafting, metallization, ion sputtering and others. An appropriate treatment can change the physico-chemical properties of the surface of a polymer in a way that makes it attractive for a variety of biological compounds, or, on the contrary, makes the polymer exhibit antibacterial or cytotoxic properties, thus making the polymer usable in a variety of biomedical applications. This review examines four popular methods of polymer surface modification: laser treatment, ion implantation, plasma treatment and nanoparticle grafting. Surface treatment-induced changes of the physico-chemical properties, morphology, chemical composition and biocompatibility of a variety of polymer substrates are studied. Relevant biological methods are used to determine the influence of various surface treatments and grafting processes on the biocompatibility of the new surfaces—mammalian cell adhesion and proliferation is studied as well as other potential applications of the surface-treated polymer substrates in the biomedical industry.

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Section: Nanoparticle Graftingmentioning

confidence: 99%

Surface Modification of Polymer Substrates for Biomedical Applications

2017

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“…This applies even for the most studied types of NPs -gold and silver ones (see reviews [42,43]). This fact was considered in our related study [9], addressing NPs biological properties. We used cathode sputtering method to prepare NPs of gold (6.1 ± 1.0 nm), silver (4.2 ± 0.9 nm), palladium (2.5 ± 0.6 nm), and platinum (1.8 ± 0.6 nm).…”

Section: Nanoparticles Cytotoxicitymentioning

confidence: 99%

“…More specifically, the NPs were tested against A549 (human lung carcinoma cells), HaCaT (human keratinocytes), RAW 264.7 (mouse macrophages), CHO-K1 (Chinese hamster ovary), NIH 3 T3 and L929 (both mouse embryonic fibroblasts), the cell lines commonly used to evaluate the cytotoxic potential of pollutants [24]. The cytotoxic potential was investigated for 24, 48 and 72 h over the NPs concentration range of 0-6.150 mg/ml [9]. Table 2, all results are summarized in the form of the half maximal inhibitory concentration (IC50).…”

Section: Nanoparticles Cytotoxicitymentioning

confidence: 99%

“…This chapter is devoted to the very contemporary themes of polymer nano-metallization, the process giving the polymers exceptional properties in biological applications, namely the bactericidal action while preserving sufficiently low cytotoxicity level [1][2][3][4][5][6][7][8], as well as to novel techniques for metal nanoparticle (NP) synthesis providing antibacterial, cell-conform entities [9,10]. So far many efforts has been spent to synthesize the next generation antimicrobial materials applicable in the health-care industry in response to increasing resistance of the pathogens to conventional antibiotics [9][10][11][12]. A lot of strategies have been developed to produce those sophisticated manmade materials which hinders their single-key classification.…”

Section: Introductionmentioning

confidence: 99%

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Structure-Dependent Biological Response of Noble Metals: From Nanoparticles, Through Nanowires to Nanolayers

Siegel¹,

Staszek²,

Polívková³

et al. 2018

Noble and Precious Metals - Properties, Nanoscale Effects and Applications

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Noble metals in their diverse nanoforms bring revolution to many fields of science and technology, as they provide unique properties over their bulk counterparts. Thanks to these completely unprecedented properties, commercial sphere pressure is growing to use them in everyday life. Unfortunately, one of the issues that are subject to dramatic changes is the reactivity of these structures. This may have often fatal consequences to the living organisms. Due to the fact that the mechanism of action of metal nanostructures on living organisms is not yet fully elucidated even in the case of the most studied noble metals such as gold and silver, it is necessary to continue intensively in their research, characterization and categorization. The main prerequisite for the undistorted study of interactions of nanostructures with living organisms is the use of suitable methods of their preparation. Within this context, this chapter attempts to summarize current knowledge form the field of synthesis of metal nanoparticles, layers, wires, and other nanostructures, especially regarding novel techniques of their preparation and extend them by our own results in this area, in the context of their biological properties. More specifically, antibacterial efficacy and potential cytotoxicity of those structures are thoroughly addressed.

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“…They may have different shapes and complex morphologies which enable to classify them into three basic groups, i.e., 0, 1 and 2 dimensional (0, 1 and 2D) nanomaterials as they are smaller than 100 nm in all directions, two axes or one axis, respectively. Nanomaterials have many shapes, whereas the most common ones are nanoparticles (0D) [1], nanowires (1D) [2], nanolayers (2D) [3]. All together, they represent basic building blocks or active components in dynamically growing field of bioengineering.…”

Section: Introductionmentioning

confidence: 99%

Nanostructured Materials for Artificial Tissue Replacements

Pryjmaková

Kaimlová

Hubáček

et al. 2020

IJMS

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This paper review current trends in applications of nanomaterials in tissue engineering. Nanomaterials applicable in this area can be divided into two groups: organic and inorganic. Organic nanomaterials are especially used for the preparation of highly porous scaffolds for cell cultivation and are represented by polymeric nanofibers. Inorganic nanomaterials are implemented as they stand or dispersed in matrices promoting their functional properties while preserving high level of biocompatibility. They are used in various forms (e.g., nano- particles, -tubes and -fibers)—and when forming the composites with organic matrices—are able to enhance many resulting properties (biologic, mechanical, electrical and/or antibacterial). For this reason, this contribution points especially to such type of composite nanomaterials. Basic information on classification, properties and application potential of single nanostructures, as well as complex scaffolds suitable for 3D tissues reconstruction is provided. Examples of practical usage of these structures are demonstrated on cartilage, bone, neural, cardiac and skin tissue regeneration and replacements. Nanomaterials open up new ways of treatments in almost all areas of current tissue regeneration, especially in tissue support or cell proliferation and growth. They significantly promote tissue rebuilding by direct replacement of damaged tissues.

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Cytotoxicity of noble metal nanoparticles sputtered into glycerol

Cited by 34 publications

References 21 publications

Surface Modification of Polymer Substrates for Biomedical Applications

Surface Modification of Polymer Substrates for Biomedical Applications

Structure-Dependent Biological Response of Noble Metals: From Nanoparticles, Through Nanowires to Nanolayers

Nanostructured Materials for Artificial Tissue Replacements

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