Cytotoxicity of Silver Compounds

Корман, Д. Б.; Ostrovskaya, L. A.; Bluhterova, N. V.; Rikova, V. A.; Фомина, М. М.

doi:10.1134/s0006350922040108

Cited by 3 publications

(2 citation statements)

References 36 publications

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“…The cytotoxicity of Ag complexes with various ligands, including several NSAIDs, against cancer cells has been observed in many studies [ 13 , 43 , 45 , 46 ]. It was reported that the mechanisms of the influence of Ag-NSAID combinations on these cells involve the induction of ROS generation, the overloading of calcium, activating caspase-3, and mitochondrial damage, with the concomitant inhibition of various antioxidant defense enzymes, leading to apoptosis [ 44 , 47 ]. Moreover, some studies have proved that such cytotoxic activity is selectively directed against cancer cell lines, or at least that the IC 50 values for cancer cells and healthy cells differ significantly, which may allow the use of such complexes in therapy without strong side effects [ 43 , 45 , 47 ].…”

Section: Resultsmentioning

confidence: 99%

“…It was reported that the mechanisms of the influence of Ag-NSAID combinations on these cells involve the induction of ROS generation, the overloading of calcium, activating caspase-3, and mitochondrial damage, with the concomitant inhibition of various antioxidant defense enzymes, leading to apoptosis [ 44 , 47 ]. Moreover, some studies have proved that such cytotoxic activity is selectively directed against cancer cell lines, or at least that the IC 50 values for cancer cells and healthy cells differ significantly, which may allow the use of such complexes in therapy without strong side effects [ 43 , 45 , 47 ]. However, this seems to depend mostly on the type of complex and, to some extent, on the cells used, as some IC 50 values reported for normal cells were also relatively low [ 13 ].…”

Section: Resultsmentioning

confidence: 99%

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Silver and Copper Complexes with Ibuprofen and Caffeine—Preparation and Evaluation of Their Selected Biological Effects

Borówka,

Sierosławska,

Baier

et al. 2024

Molecules

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Several organometallic complexes based on more than twenty different metals have already been approved for medical applications. The aim of the presented research was to obtain complexes of silver and copper with the non-steroidal anti-inflammatory drugs ibuprofen and xanthine alkaloid caffeine and evaluate selected aspects of their bioactivity and biosafety in terms of their future possible applications. The obtained complexes were characterized by Fourier-transform infrared spectroscopy, thermogravimetry, UV-VIS spectroscopy, conductometry, elemental analysis, and bioassays. Cytotoxicity for normal human cells of the CCD-Co18 cell line was evaluated by determining the IC50 value, with metabolic and morphology assessments. It was observed that complexes containing ibuprofen and caffeine exhibited lower toxicity than those with ibuprofen only. Complexes with copper showed lower toxicity towards healthy human fibroblasts compared to silver-based compounds, with an IC50 above 140 μg mL−1. However, in the silver complexes, the presence of caffeine increased the potency of COX-2 inhibition. Antimicrobial effects against different Gram-positive and Gram-negative bacterial strains were evaluated by MIC determination with values less than 20 μg mL−1.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Silver and Copper Complexes with Ibuprofen and Caffeine—Preparation and Evaluation of Their Selected Biological Effects

Borówka,

Sierosławska,

Baier

et al. 2024

Molecules

View full text Add to dashboard Cite

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Gold and Silver Compounds as Potential Antitumor Drugs

Ostrovskaya,

Korman,

Nekrasova

et al. 2024

BIOPHYSICS

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Nanostructured Metal Polyacrylates as Both Local Hemostatics and Antimicrobials

A. Abzaeva,

G. Sukhov

2024

Nanotechnology and Nanomaterials

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A methodological approach to directed synthesis of biopharmaceutical composites allows solving an urgent problem: the development of fundamentally new high-molecular materials intended for the interaction of synthetic substances with the biological environment, e.g., with blood. Polymer composites containing ionogenic groups and nanoparticles are capable of complementary conformational transformations and cooperative binding. Functional polymer materials with a wide range of biological activity have been designed on the basis of essential elements and nanoparticles of noble metals. Potential hemostatics with unique properties are proposed. They can be employed as universal agents in a wide variety of surgical operations, as well as for healing the wounds and injuries in case of emergency. At the same time, they stop bleeding even in patients with disorders of the blood coagulation system. The polymer composites can find application as unprecedented, highly effective drugs with a wide range of pharmacological activity. Innovative potential drugs based on polymer composites acting as hemostatics, asepsis, antiseptics without antibiotics, reparants, analgesics, and cytostatics can effectively solve the problems of modern medicine including disaster medicine.

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Cytotoxicity of Silver Compounds

Cited by 3 publications

References 36 publications

Silver and Copper Complexes with Ibuprofen and Caffeine—Preparation and Evaluation of Their Selected Biological Effects

Silver and Copper Complexes with Ibuprofen and Caffeine—Preparation and Evaluation of Their Selected Biological Effects

Gold and Silver Compounds as Potential Antitumor Drugs

Nanostructured Metal Polyacrylates as Both Local Hemostatics and Antimicrobials

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