Cytotoxicity of some modified root canal sealers and their leachable components

Barbosa, Sergio; Araki, Koji; Spångberg, Larz S.W.

doi:10.1016/0030-4220(93)90151-s

Cited by 45 publications

(29 citation statements)

References 11 publications

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“…19, 20 The method has been used extensively vestigated are tapped gum resins that originate from when evaluating the cytotoxicity of dental materials, 21,22 Pinus palestris and P. sylvestris (oleoresin #1) and P. and we have found that the results of the 51 Cr technique massoniana (oleoresin #2). correlates well with supravital staining and cellular degeneration evaluated by electron microscopy 23 as well as with neutral red uptake.…”

Section: The Chemical Composition Of Rosins Greatly Affectsmentioning

confidence: 98%

“…2 However, a direct action of zinc on the cells also may be expected as zinc readily binds to interpreted as an indication of the concentrations at which the test substances becomes highly toxic. 22 cellular membranes, 51,52 which are thereby stabilized. 53 This also is indicated by the dose-dependent decrease Dehydroabietic acid (DHAA) is one of the constituent resin acids of oleoresin and rosins.…”

Section: Table II Effects Of Zinc On the Spontaneous Release Ofmentioning

confidence: 98%

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The protective effect of zinc on rosin and resin acid toxicity in human polymorphonuclear leukocytes and human gingival fibroblastsin vitro

Sunzel

Söderberg

Johansson

et al. 1997

J. Biomed. Mater. Res.

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Combinations of rosin and zinc are used in dentistry as components of periodontal dressings and cements and as root canal sealers. The composition and properties of rosins differ largely depending on source and refinement processes. Rosin (colophony) is composed of approximately 70% resin acids. In order to study the toxic effects of different natural rosins and purified resin acids and the detoxifying effects of zinc, these compounds were analyzed and tested on human polymorphonuclear leukocytes (PMN cells) and human gingival fibroblasts using the radiochromium release method. The rosins and the pure resin acids showed a strong dose-related cytotoxicity, which was inhibited by increased zinc concentrations. The purified resin acids (isopimaric, levopimaric, and neoabietic acid) were more toxic than the natural rosins. The contents of these resin acids might explain the difference in toxicity of the rosins tested. It is concluded that rosin and zinc are not to be considered inert compounds and that the cytoprotective effects of zinc and its role in dentistry products merit further investigations.

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Section: The Chemical Composition Of Rosins Greatly Affectsmentioning

confidence: 98%

Section: Table II Effects Of Zinc On the Spontaneous Release Ofmentioning

confidence: 98%

The protective effect of zinc on rosin and resin acid toxicity in human polymorphonuclear leukocytes and human gingival fibroblastsin vitro

Sunzel

Söderberg

Johansson

et al. 1997

J. Biomed. Mater. Res.

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“…However, it has been reported that the apical extent of root fillings seems to have no correlation with treatment failure, provided infection is absent (6, 7, 13, 141). Apart from the paraformaldehyde‐containing materials, most of the materials used in root fillings are either biocompatible or show cytotoxicity only prior to setting (41–43, 142, 143). Therefore, it is highly unlikely that most of the contemporary endodontic materials by themselves are able to sustain a periradicular inflammation when overfilled in the absence of a concomitant endodontic infection.…”

Section: Influence Of Overfilling On Treatment Outcomementioning

confidence: 99%

Reaction of periradicular tissues to root canal treatment: benefits and drawbacks

Siqueira¹

2005

Endodontic Topics

108

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Tissue injury induced by intra‐canal procedures and substances extruded through the apical foramen may influence the development of post‐operative pain as well as the outcome of root canal treatment. While the development of pain is related to the intensity of tissue damage, treatment outcome is more dependent on the persistence of the source of injury. Procedural errors are the main causative agents of either post‐operative pain or persistent periradicular lesions. However, even when the treatment has followed the highest standards, post‐operative pain can occur and periradicular disease can persist, albeit at a lower incidence when compared to teeth treated to a poor technical standard. This paper critically reviews the effects of intra‐canal procedures on the periradicular tissues, with special emphasis on the occurrence of post‐operative pain and the outcome of the root canal treatment. The possible systemic effects stemming from root canal procedures are also discussed in the light of current knowledge.

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“…2003). Root canal filling materials have been formulated in an attempt to obtain better physical and biological properties (Barbosa et al. 1993).…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity of new resin‐, calcium hydroxide‐ and silicone‐based root canal sealers on fibroblasts derived from human gingiva and L929 cell lines

et al. 2007

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Cytotoxicity of some modified root canal sealers and their leachable components

Cited by 45 publications

References 11 publications

The protective effect of zinc on rosin and resin acid toxicity in human polymorphonuclear leukocytes and human gingival fibroblastsin vitro

The protective effect of zinc on rosin and resin acid toxicity in human polymorphonuclear leukocytes and human gingival fibroblastsin vitro

Reaction of periradicular tissues to root canal treatment: benefits and drawbacks

Cytotoxicity of new resin‐, calcium hydroxide‐ and silicone‐based root canal sealers on fibroblasts derived from human gingiva and L929 cell lines

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