Cytotoxicity of Substituted Alkyl-3,4-bis(4-methoxyphenyl)pyrrole-2-carboxylates in L1210 Lymphoid Leukemia Cells

Abstract

Arch. Pharm. Pharm. Med. Chem.

Efficient synthesis of Some Novel Symmetrical and Unsymmetrical Pyridine bis-1,2,4-triazoles and bis-1,3,4-thiadiazoles

“…The 1 H NMR spectra (DMSO-d 6 ) of compounds 5a-f displayed the NH resonances in the range 8.10-10.80 ppm. Further structural confirmation was provided by the 13 C NMR spectra of compounds 3a-f which exhibited the expected 13 C NMR and 1 H NMR correlations. The spectra of compounds 5a-f provided further confirmation for the formation of the expected structures and were in support of conversion of thiosemicarbazides to triazoles and thiadiazoles.…”

“…-1 : 3092 (CH-aromatic), 2912 (CH 3 ), 2766 (S-H), 1556, 1504 (C=N), 1290 (C=S); 1 H NMR (DMSO-d 6 ) δ 3.60 (s, 3H, CH 3 ), 3.86 (s, 3H, CH 3 ), 8.16 (d, 1H, ArH, J = 8.1 Hz), 8.37 (d, 1H, ArH, J = 8.1 Hz), 9.06 (s, 1H, py-H), 14.14 (s, 2H, SH, exchangeable with D 2 O) 13. C NMR (DMSO-d 6 ) δ 31.2, 31.4, 122.6, 131.0, 137.6, 148.1, 152.0, 162.8, 163.4, 164.6, 182.4.…”

“…(3a): Yield 94%; m.p. 245-247 °C; IR (KBr) ν max / cm -1 : 3257-3153 (NH), 2987 (CH-aromatic), 2941 (CH 3 ), 1701 (C=O), 1282 (C=S);1 H NMR (DMSO-d 6 ) δ 2.88 (s, 6H, 2 × CH 3 ), 8.12 (3H, ArH), 8.24 (s, 2H, NH, exchangeable with D 2 O), 9.48 (s, 2H, NH, exchangeable with D 2 O), 10.98 (s, 2H, NH, exchangeable with D 2 O) 13. C NMR (DMSO-d 6 ) δ 31.3, 124.6, 141.0, 147.5, 165.5, 182.6.…”