Cytotoxicity of Substituted Benzimidazolyl Curcumin Mimics Against Multi-Drug Resistance Cancer Cell

Eom, Young Woo; Oh, Sangtae; Woo, Ho Bum; Ham, Jungyeob; Ahn, Chan Mug; Lee, Seokjoon

doi:10.5012/bkcs.2013.34.4.1272

Cited by 6 publications

(2 citation statements)

References 23 publications

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“…The procedures were conducted according to the literature [16]. Glycolic acid (15.24 g, 0.2 mol) was dissolved in 40 mL HCl (20% aqueous) in the flask.…”

Section: Methodsmentioning

confidence: 99%

Synthesis and Biological Evaluation of Benzimidazole Phenylhydrazone Derivatives as Antifungal Agents against Phytopathogenic Fungi

et al. 2016

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A series of benzimidazole phenylhydrazone derivatives (6a-6ai) were synthesized and characterized by 1 H-NMR, ESI-MS, and elemental analysis. The structure of 6b was further confirmed by single crystal X-ray diffraction as (E)-configuration. All the compounds were screened for antifungal activity against Rhizoctonia solani and Magnaporthe oryzae employing a mycelium growth rate method. Compound 6f exhibited significant inhibitory activity against R. solani and M. oryzae with the EC 50 values of 1.20 and 1.85 µg/mL, respectively. In vivo testing demonstrated that 6f could effectively control the development of rice sheath blight (RSB) and rice blast (RB) caused by the above two phytopathogens. This work indicated that the compound 6f with a benzimidazole phenylhydrazone scaffold could be considered as a leading structure for the development of novel fungicides.

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“…The procedures were conducted according to the literature [16]. Glycolic acid (15.24 g, 0.2 mol) was dissolved in 40 mL HCl (20% aqueous) in the flask.…”

Section: Methodsmentioning

confidence: 99%

Synthesis and Biological Evaluation of Benzimidazole Phenylhydrazone Derivatives as Antifungal Agents against Phytopathogenic Fungi

et al. 2016

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“…MDR refers to the phenomenon that tumor cells are resistant to the structurally unrelated drugs without a clear mechanism (Takács et al, 2015; Domínguez‐Álvarez et al, 2016; Eom et al, 2013; Ferreira et al, 2018), which lead to the failure of clinical treatment. Therefore, the development of MDR inhibitors and more safe and effective antineoplastic agent has become a worth focus.…”

Section: Introductionmentioning

confidence: 99%

Application of curcumin and its derivatives in tumor multidrug resistance

Guo

et al. 2020

Phytotherapy Research

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Malignant tumor endangers seriously the health of all mankind. Multidrug resistance (MDR) is one of the main causes of clinical tumor chemotherapy failure. Curcumin (CUR) has not only antitumor activity but also reversing tumor MDR effect. CUR reverses tumor MDR via regulating related signal pathways or corresponding expressed proteins or gene. When combined with chemotherapeutic agents, CUR can be a chemotherapeutic sensitive agent to enhance chemotherapy efficacy and weaken tumor MDR. On the other hand, to improve the MDR reversal effect of CUR, its derivatives have been extensively studied. Therefore, this article mainly focuses on reviewing the application of CUR and its derivatives in MDR and its mechanism of reversing MDR.

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An appraisal on recent medicinal perspective of curcumin degradant: Dehydrozingerone (DZG)

Hampannavar

Karpoormath

Palkar

et al. 2016

Bioorganic & Medicinal Chemistry

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Cytotoxicity of Substituted Benzimidazolyl Curcumin Mimics Against Multi-Drug Resistance Cancer Cell

Cited by 6 publications

References 23 publications

Synthesis and Biological Evaluation of Benzimidazole Phenylhydrazone Derivatives as Antifungal Agents against Phytopathogenic Fungi

Synthesis and Biological Evaluation of Benzimidazole Phenylhydrazone Derivatives as Antifungal Agents against Phytopathogenic Fungi

Application of curcumin and its derivatives in tumor multidrug resistance

An appraisal on recent medicinal perspective of curcumin degradant: Dehydrozingerone (DZG)

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