Cytotoxicity study of ethanol extract of the stem bark of asam kandis (Garcinia cowa Roxb.) on T47D breast cancer cell line

Husni, Elidahanum; Nahari, Faras; Wirasti, Yan; Wahyuni, Fatma Sri; Hamidi, Dachriyanus

doi:10.1016/s2221-1691(15)30013-7

Cited by 23 publications

(18 citation statements)

References 9 publications

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“…The IC 50 values of OTH‐P, OTH‐T and OTH‐PT against HeLa cells were 4.67, 1.22, and 0.78 mg mL −1 , respectively (Table ). The observation of morphological changes in cell lines was used in many studies to confirm cell proliferation . The morphological changes in HeLa cells by OTF or OTF hydrolysate treatments are shown in Fig.…”

Section: Resultsmentioning

confidence: 99%

Antioxidant and anticancer effects of functional peptides from ovotransferrin hydrolysates

et al. 2017

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Section: Resultsmentioning

confidence: 99%

Antioxidant and anticancer effects of functional peptides from ovotransferrin hydrolysates

et al. 2017

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“…7 The chemical composition and biological activities of various parts of G. cowa have been investigated. 8 In the previous paper, we have reported cytotoxicity study of ethanol extract 9 and cytotoxic xanthones from the stem bark of G. cowa. 10 A new ring reduced prenyltoluquinone, Tetraprenyltoluquinone (TPTQ) (Figure 1) was first isolated for G. cowa.…”

Section: Introductionmentioning

confidence: 99%

In vivo study of tetraprenyltoluquinone, an anticancer compounds from Garcinia cowa Roxb

Wahyuni¹,

Hui²,

Stanslas³

et al. 2017

JYP

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Objective: To investigate the in vivo antitumor effect of TPTQ against H-460 lung cancer cell lines in nude mice. Materials and Methods: Female nude mice bearing H-460 tumor at size approximately 5 mm in diameter were treated with a single intraperitoneal dose 800 mg/kg of TPTQ. The vehicletreated (10% tween 80) animals were used as control group. The tumor size and mice body weight were measured for 14 days. Results: Single treatment of 800 mg/kg of TPTQ displayed moderate antitumor activity against H-460 tumor xenografts as compared with vehicle-treated control. The mean time to reach RTV of 4 for vehicle-treated control group was 4.5 days whereas for TPTQ-treated (800 mg/kg) group was 9.5 days. Conclusion:The results showed that TPTQ slowed the tumor growth by 5 days. Thus, TPTQ may be considered as a promising compound in cancer chemotherapy.

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“…5,6 G. cowa is potential as chemopreventive agents have been studied in vitro against various types of cancer cells, such as HL-60 (leukemia), MCF-7 (breast), DU-45 (prostate), NCI-H460 (NSCL) and T47D (breast). [7][8][9][10] A preliminary study showed that dichloromethane (DCM) fraction from the rinds of G. cowa is known to have a cytotoxic effect on HeLa cervical cancer cells with IC 50 value of 5.764 µg/mL. Through this study, the apoptosis induction of HeLa cervical cancer cell death by DCM fraction of the rinds of G. cowa are studied further to develop cancer therapies, especially herbal medicine.…”

Section: Introductionmentioning

confidence: 99%

Apoptosis Induction of Cervical Carcinoma HeLa Cells Line by Dichloromethane Fraction of the Rinds of Garcinia cowa Roxb

Wahyuni¹,

Siska²,

Arisanty³

2017

Phcog J

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Objective: This study aims to determine the apoptosis induction of HeLa cervical carcinoma cells death by dichloromethane fraction of the rinds of Garcinia cowa Roxb. Methods: Apoptosis induction of HeLa cell line was observed using a double staining method. Results: The result of double staining observation showed that an apoptosis occurs which marked with yellowish green fluorescence and cell fragmentation. The average percentage of apoptotic cells was higher in the treated variables (70.38%) compared to the control variables (12.26% ). Statistical analysis by Independent Sample T-Test showed apoptosis Sig. (2-tailed) = 0.000 (<0.025). Conclusion: The dichloromethane fraction of G. cowa rind induces apoptosis in HeLa cervical cancer cells.

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Cytotoxicity study of ethanol extract of the stem bark of asam kandis (Garcinia cowa Roxb.) on T47D breast cancer cell line

Cited by 23 publications

References 9 publications

Antioxidant and anticancer effects of functional peptides from ovotransferrin hydrolysates

Antioxidant and anticancer effects of functional peptides from ovotransferrin hydrolysates

In vivo study of tetraprenyltoluquinone, an anticancer compounds from Garcinia cowa Roxb

Apoptosis Induction of Cervical Carcinoma HeLa Cells Line by Dichloromethane Fraction of the Rinds of Garcinia cowa Roxb

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