Cytotoxicity study of polyethylene glycol derivatives

Liu, Guoqiang; Li, Yongsan; Yang, Lei; Wei, Yen; Wang, Xing; Wang, Zhiming; Tao, Lei

doi:10.1039/c7ra00861a

Cited by 152 publications

(104 citation statements)

References 52 publications

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“…They also corroborated that at higher doses PEG is more cytotoxic. Liu et al contributed the PEG cytotoxicity to the reactive oxygen species (ROS) generation, which is generated by PEG derivates [50]. In this study we presented an analysis of the PEG degradation, which showed the disappearance of bonds from the PEG polymer generating derivatives, which correlates also with the formation of ROS.…”

Section: Interactions With Erythrocytes Membranesmentioning

confidence: 84%

Magnetite Nanoparticles Coated with PEG 3350-Tween 80: In Vitro Characterization Using Primary Cell Cultures

et al. 2020

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Some medical applications of magnetic nanoparticles require direct contact with healthy tissues and blood. If nanoparticles are not designed properly, they can cause several problems, such as cytotoxicity or hemolysis. A strategy for improvement the biological proprieties of magnetic nanoparticles is their functionalization with biocompatible polymers and nonionic surfactants. In this study we compared bare magnetite nanoparticles against magnetite nanoparticles coated with a combination of polyethylene glycol 3350 (PEG 3350) and polysorbate 80 (Tween 80). Physical characteristics of nanoparticles were evaluated. A primary culture of sheep adipose mesenchymal stem cells was developed to measure nanoparticle cytotoxicity. A sample of erythrocytes from a healthy donor was used for the hemolysis assay. Results showed the successful obtention of magnetite nanoparticles coated with PEG 3350-Tween 80, with a spherical shape, average size of 119.2 nm and a zeta potential of +5.61 mV. Interaction with mesenchymal stem cells showed a non-cytotoxic propriety at doses lower than 1000 µg/mL. Interaction with erythrocytes showed a non-hemolytic propriety at doses lower than 100 µg/mL. In vitro information obtained from this work concludes that the use of magnetite nanoparticles coated with PEG 3350-Tween 80 is safe for a biological system at low doses.

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Section: Interactions With Erythrocytes Membranesmentioning

confidence: 84%

Magnetite Nanoparticles Coated with PEG 3350-Tween 80: In Vitro Characterization Using Primary Cell Cultures

et al. 2020

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“…31,32 However, PEG is a commonly used MMC agent for studies of biomolecular polymerization, like actin, and has been shown to be non-toxic for several different cell types including fibroblasts, cancer cells and stem cells. 33,34 Additionally, PEG is a widely used material for the preparation of hydrogels for the study of cell migration and morphogenesis programs. 35 Thus, we chose to test PEG for our purposes.…”

Section: Macromolecular Crowding With Peg Tunes Collagen Fibrilsmentioning

confidence: 99%

Macromolecular crowding tunes 3D collagen architecture and cell morphogenesis

et al. 2019

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“…In addition, a cytotoxic effect, caused by the increase in the levels of Reactive Oxygen Species (ROSs), was also informed. This last hypothesis was recently confirmed by Liu et al on both Human Cervical cancer cells (HeLa) and on mouse fibroblasts (L929), which exhibited up to 400% increase on ROSs levels, compared to the controls, when cultures were exposed to high concentrations of PEG 200 . Given these chemoprotective properties of PEG, we decided to include these monomers in the new materials, which should, in principle, help to increase the long term efficiency of PTX.…”

Section: Introductionmentioning

confidence: 67%

Poly‐(pentaerythritol adipate)‐co‐(poly ethylene glycol) Elastomers for the Sustained Release of Paclitaxel

Navarro

Minari

Ceaglio

et al. 2018

J. Polym. Sci. Part A: Polym. Chem.

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Over the past 10 years poly‐(polyol alkanoate)s elastomers have intensively been investigated due to their extraordinary potential for soft tissue engineering applications. In this work, a family of novel hyperbranched elastomers based on pentaerythritol and adipic acid, modified with PEG of 200 and 400 Da, is synthesized. The polymers are obtained by a simple 2 steps thermal process that avoids the use of toxic catalysts. Noteworthy, elastomers properties can be finely tuned by adjusting the molar ratio of monomers and curing conditions. The elastomers, which are fully characterized by standard methods, show excellent results in the in vitro controlled release of Paclitaxel. Cell culture assays indicate that all materials are able to inhibit lung cancer cell proliferation and that the release of Paclitaxel reduce cancer cell viability, indicating that the elastomers prepared hereby are good candidates for their use as eluting systems in long term cancer treatment. © 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2018, 56, 1199–1209

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Cytotoxicity study of polyethylene glycol derivatives

Abstract: Cytotoxicity of PEG oligomers (with different molecular weights) and PEG based monomers (with different chain end groups) was studied in detail.

Cited by 152 publications

References 52 publications

Magnetite Nanoparticles Coated with PEG 3350-Tween 80: In Vitro Characterization Using Primary Cell Cultures

Magnetite Nanoparticles Coated with PEG 3350-Tween 80: In Vitro Characterization Using Primary Cell Cultures

Macromolecular crowding tunes 3D collagen architecture and cell morphogenesis

Poly‐(pentaerythritol adipate)‐co‐(poly ethylene glycol) Elastomers for the Sustained Release of Paclitaxel

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