Cytotoxicity study of some indophenines and isatin derivatives

Abstract

Eight indophenines were synthesized for the interest of studying biological activity especially for cytotoxicity. The cytotoxicity of some indophenines and some isatin derivatives was studied by the brine shrimp lethality bioassay. It was observed that all the indophenines from thiophene, thiazol and isatin derivatives showed potential cytotoxicity against brine shrimp nauplii and the structure activity relationships (SAR) of these compounds have been reported. Article Info

Cytotoxicity study of reaction products between isatin and furan

“…The chemical structure of a compound is very important as the relatively minor modification in the compound may result in major change in biological properties. The isatin (1a), 5-chloroisatin (1b), 7-bromoisatin (1c) shows moderately cytotoxicity (Hoque and Islam, 2008) as 1c> 1b>1a whereas the inserted furan moiety products show higher cytotoxicity. The cytotoxicity enhancement is due to presence of hetero atom O in the furan ring.…”

“…It is to be noted here that the products having furan moiety has potential cytotoxicity than the corresponding thiophene analogues (Hoque and Islam, 2008) in every cases (Scheme 3). This cytotoxicity enhancement is caused by the presence of O atom in furan ring because O is more electronegative than S atom in thiophene ring.…”

“…In continuation of our systematic studies (Islam et al, 2001) on isatin derivatives as potential cytotoxic agents, we extended our work on the reaction between isatin and thiophene (Hoque and Islam, 2008). Isatin reacted with thiophene in presence of conc.…”

Sick Leave Determinants in the Healthcare Sector (Part III): A Review of Individual-Level Factors

“…101,102 Robbins et al demonstrated that studies consistently show an inverse relationship between tenure and absenteeism, which means that employees with higher work experience will be less absent than those with lower work experience or length of employment. 103 Employees who have been in employment for long periods tend to express higher levels of job satisfaction and organizational commitment, resulting in lower rates of absenteeism. 104 Bamgboye and Adeleye reported from Nigeria, in their retrospective analysis of sickness absence records of all hospital employees, that younger employees and those employed for shorter periods of time had a higher rate and duration of absence.…”

“…105 Contrary to previous studies, Mollazadeh et al found a considerable variation between duration of employment and sickness absence spells, while Hoque and Islam found that workers with higher work experience report higher levels of absenteeism than workers with lower work experience. 23,103 The authors attributed this to the fact that the employees with higher work experiences or duration believe they have been loyal to their organization and are entitled to a few days of sickness absence. Older age and more senior tenure are factors that represent significantly higher rates of presenteeism, which was consistent with the results of Bierla et al on age, and that of Martinez and Ferreira on tenure.…”