Czy nowe leki przeciwhistaminowe cechuje zjawisko tachyfilaksji?

Kłos, Krzysztof; Kruszewski, Jerzy

doi:10.1016/s0030-6657(07)70551-6

Cited by 3 publications

(2 citation statements)

References 8 publications

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“…Tachyphylaxis is not known to occur in H1 receptor blockade. In fact, a study which addressed this issue in allergic rhinitis patients treated for 180 days with cetirizine or levocetirizine found no evidence of tachyphylaxis [46]. Furthermore, once response to initially prescribed dosing is lost, subsequent response to increasing doses (the hallmark of early tachyphylaxis) is not observed in patients with allergic CV.…”

Section: Cholinergic Modulation Of Inflammationmentioning

confidence: 99%

Neuromodulation in the Management of Allergic Chronic Vaginitis

Theodoropoulos¹,

Àlex²,

Michalopoulou³

et al. 2016

Reprod Syst Sex Disord

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Chronic vaginitis (CV) affects 16% of women. While a number of distinct diagnoses account for the underlying causes of CV, allergic inflammation is also present in a significant number of cases and may range from 25 to 54% of CV patients. Allergic inflammation in CV is encountered as a result of: i) direct sensitization of the vaginal mucosa to latex, local products, Candida, bacteria, etc.; ii) inhalant allergy compounding the chronic vaginitis syndrome; iii) immune cell activation secondary to neurogenic inflammation in the context of chronic neuropathic pain. Despite the varying nature of specific neuro-immune interactions, chronic pain/irritation remains a cardinal feature of CV which needs to be addressed as a priority independently of specific gynecological or allergy-modifying interventions. This is necessary not only for reasons of symptom relief but also because long-term neuronal changes due to inflammation and chronic pain have a profound effect on the course of CV by potentiating adverse pro-inflammatory and degenerating processes. The pathophysiology of these processes and their alteration by means of neuromodulators is presented with a view of long-term control of chronic pain and neurogenic inflammation. Special emphasis is placed on gamma-aminobutyric acid-served pathways, the use of tricyclic antidepressants, serotoninreuptake inhibitors and certain antihistamines with anti-serotoninergic properties.

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Section: Cholinergic Modulation Of Inflammationmentioning

confidence: 99%

Neuromodulation in the Management of Allergic Chronic Vaginitis

Theodoropoulos¹,

Àlex²,

Michalopoulou³

et al. 2016

Reprod Syst Sex Disord

View full text Add to dashboard Cite

show abstract

“…Multiple studies have shown that the effectiveness of the newer drugs in ameliorating the effect of histamine release in the skin continues unchanged for up to 30 18 to 180 days. 19 Patients may mistake an intensification of the underlying symptoms for a waning in effectiveness of the antihistamine. There are situations in which a pre-emptive intensification of treatment may be required -such as before contact with a known trigger or in the weeks before the onset of the spring pollen season.…”

Section: Tachyphylaxismentioning

confidence: 99%