D-Carvone, a Monoterpene Reverses Alterations in Heart Rate, Nitric Oxide, Aortic Lipids and Enzymatic Antioxidant Status in Nitric Oxide Deficient Hypertensive Rats

Rajeshwari, Thiyagarajan; Raja, Boobalan

doi:10.18052/www.scipress.com/ilns.32.19

Cited by 3 publications

(2 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, Carum carvi containing (S)-(+)-carvone significantly decreased serum TGs, LDL-C, and total cholesterol levels in rats ( 31 ). Similarly, oral administration of Anethum graveolens essential oil containing 28% S-carvone ( 32 ) to rats reduced TC, TGs and LDL-C and increased significantly HDL-C. S-carvone also lowered cholesterol level in two rat disease models: in diabetic rats ( 11 ) and in L-NAME hypertensive rats ( 10 ). It is important to consider that the metabolism of R- and S-carvone is stereoselective in phase-I and phase-II.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Hypolipidaemic and Insulin Secretagogue Activities of (R)-(−)-Carvone

Abbas

Oriquat

Al-Najjar

et al. 2020

MJMS

View full text Add to dashboard Cite

Background: Dyslipidaemias are common in patients with diabetes mellitus. A high prevalence of type 2 diabetes in hyperlipidaemic patients also exists. The aim of this study was to find a treatment that lowers both blood glucose and lipid levels simultaneously. Methods: The hypolipidaemic effect of (R)-(−)-carvone was investigated in a tyloxapol- induced hyperlipidaemia mice model. Furthermore, its effect on insulin secretion and proliferation of 1.1E7 human pancreatic β-cells was studied. In addition, using molecular docking, the binding affinity of (R)-(−)-carvone against 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG- CoA) reductase was estimated. Results: (R)-(−)-carvone (100 mg/kg) decreased plasma triglyceride, total cholesterol, low-density lipoprotein cholesterol (LDL-C) levels and atherogenic index by 90.6%, 49.3%, 56.6% and 70.3%, respectively, but it had no effect on high-density lipoprotein cholesterol (HDL-C). Furthermore, it increased hepatic triglyceride level and catalase activity by 79.6% and 59.6%, respectively. In-vitro, 500 μM (R)-(−)-carvone increased insulin secretion by 454.4% and proliferation of 1.1E7 cells with no cytotoxic effects up to a concentration of 100 μM. Molecular docking simulation demonstrated a good binding affinity with –5.03 Kcal/mol of (R)-(−)-carvone to HMG-CoA reductase. Conclusion: The hypolipidaemic effect of (R)-(−)-carvone is comparable to that of fenofibrate. (R)-(−)-carvone has the advantage over fenofibrate of not producing hypoglycaemia in animals. Furthermore, (R)-(−)-carvone increased proliferation and insulin secretion of human pancreatic β-cells.

show abstract

Section: Discussionmentioning

confidence: 99%

“…In L-NAME (Nω-nitro-L-arginine methyl ester hydrochloride) hypertensive rats, (S)-(+)-carvone supplementation prevented the development of hyperlipidaemia ( 10 ). Furthermore, Mentha spicata containing 51.7% (R)-carvone had a hypocholesterolaemic effect in diabetic rats ( 11 ).…”

Section: Introductionmentioning

confidence: 99%

Hypolipidaemic and Insulin Secretagogue Activities of (R)-(−)-Carvone

Abbas

Oriquat

Al-Najjar

et al. 2020

MJMS

View full text Add to dashboard Cite

show abstract

Monoterpenes and their derivatives as agents for cardiovascular disease management: A systematic review and meta-analysis

et al. 2021

View full text Add to dashboard Cite

D-Carvone Attenuates CCl4-Induced Liver Fibrosis in Rats by Inhibiting Oxidative Stress and TGF-ß 1/SMAD3 Signaling Pathway

Ogaly

Aldulmani

Al‐Zahrani

et al. 2022

Biology

View full text Add to dashboard Cite

D-carvone is a natural monoterpene found in abundance in the essential oil of aromatic medicinal plants with a wide range of pharmacological values. However, the impact of D-carvone on liver fibrosis remains unclear. This study aimed to evaluate the anti-fibrotic potential of D-carvone in a rat model of liver fibrosis and to clarify the possible underlying mechanisms. Liver fibrosis was induced in rats by carbon tetrachloride, CCl4 (2.5 mL/kg, interperitoneally every 72 h for 8 weeks). Oral treatment of rats with D-carvone (50 mg/kg, daily) started on the 3rd week of CCl4 administration. D-carvone significantly enhanced liver functions (ALT, AST), oxidant/antioxidant status (MDA, SOD, GSH, total antioxidant capacity; TAC), as well as histopathological changes. Moreover, D-carvone effectively attenuated the progression of liver fibrosis, evident by the decreased collagen deposition and fibrosis score by Masson trichrome staining (MT) and α-SMA protein expression. Moreover, D-carvone administration resulted in a significant downregulation of the pro-fibrogenic markers TGF-β1 and SMAD3 and upregulation of MMP9. These findings reveal the anti-fibrotic effect of D-carvone and suggest regulation of the TGF-β1/SMAD3 pathway, together with the antioxidant activity as a mechanistic cassette, underlines this effect. Therefore, D-carvone could be a viable candidate for inhibiting liver fibrosis and other oxidative stress-related hepatic diseases. Clinical studies to support our hypothesis are warranted.

show abstract

D-Carvone, a Monoterpene Reverses Alterations in Heart Rate, Nitric Oxide, Aortic Lipids and Enzymatic Antioxidant Status in Nitric Oxide Deficient Hypertensive Rats

Cited by 3 publications

References 38 publications

Hypolipidaemic and Insulin Secretagogue Activities of (R)-(−)-Carvone

Hypolipidaemic and Insulin Secretagogue Activities of (R)-(−)-Carvone

Monoterpenes and their derivatives as agents for cardiovascular disease management: A systematic review and meta-analysis

D-Carvone Attenuates CCl4-Induced Liver Fibrosis in Rats by Inhibiting Oxidative Stress and TGF-ß 1/SMAD3 Signaling Pathway

Contact Info

Product

Resources

About