d-chiro-inositol glycan reduces food intake by regulating hypothalamic neuropeptide expression via AKT-FoxO1 pathway

Jeon, Yoonjeong; Ronnett, Gabriele V.; Kim, Eun Kyoung

doi:10.1016/j.bbrc.2016.01.115

Cited by 12 publications

(10 citation statements)

References 30 publications

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“…However, data supporting the beneficial influence of DCI in the regulation of body mass, through the central regulation of food intake can be found. Jeon et al [63] demonstrated the effect of DCI on hypothalamic insulin signaling, by increasing the expression of anorexigenic neuropeptides (proopiomelanocortin) and orexigenic reduction (neuropeptide Y). After injection of DCI derivative, the intake of food and body weight in mice decreased [63].…”

Section: Cyclitols Insulin Resistance and Diabetesmentioning

confidence: 99%

The Healing-Promoting Properties of Selected Cyclitols—A Review

et al. 2018

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Introduction: Myo-inositol and its derivatives cyclitols play an important role in the processes of cell regulation, signal transduction, osmoregulation, and ion channel physiology, and are a component of the cell membrane. Free cyclitols present in food or released during the degradation of galactosyl cyclitols by bacteria (in digestive tract) show some physiological benefits. Aim: The aim of this paper is to present and analyze the documented data about curative and healing properties of cyclitols. Results and discussion: Cyclitols are well known compounds in the treatment of an accompanied diabetes insulin resistance, and also obesity and polycystic ovarian syndrome. d-chiro-Inositol deficiency exacerbates insulin resistance in the liver, muscles, and fat, while depletion of myo-inositol results in the development of diabetic complications. Cyclitols are successfully applied in treatment of polycystic ovarian syndrome, simultaneous are observed effective reducing of BMI, improving the hormonal profile, and increasing fertility. Moreover, cyclitols have anti-atherogenic, anti-oxidative, anti-inflammatory, and anti-cancer properties. Conclusion: The properties of cyclitols may be a good therapeutic option in the reduction of metabolically induced inflammation. Due to well drugs tolerance and low toxicity of these compounds, cyclitols are recommend for pregnant women and also for children. Another advantage is their widespread presence and easy availability, which encourages their use in medicine.

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Section: Cyclitols Insulin Resistance and Diabetesmentioning

confidence: 99%

The Healing-Promoting Properties of Selected Cyclitols—A Review

et al. 2018

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“…injection of insulin can inhibit food intake through the regulation of PI3K signaling in the hypothalamus [14]. Moreover, in the hypothalamus, the forehead box-containing protein of the O subfamily (FoxO)1—a downstream transcription factor of the insulin-signaling pathway—has a dual function: inhibiting the expression of POMC and stimulating the expression of NPY leading to an increased food intake [15, 16]. On the other hand, FoxO1 activities are also regulated by the InsR/PI3K/Akt signaling pathway, in which insulin induces Akt phosphorylation, followed by inactivation of FoxO1 due to its phosphorylation by p-Akt [17].…”

Section: Introductionmentioning

confidence: 99%

Cyclocarya paliurus (Batal.) Ijinskaja Aqueous Extract (CPAE) Ameliorates Obesity by Improving Insulin Signaling in the Hypothalamus of a Metabolic Syndrome Rat Model

Yoshitomi

Sun

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Background Antiobesity drugs may not be optimal for treating obesity. However novel antiobesity agents, especially those derived from natural products, may be suitable. Therefore, we investigated the effects and mechanisms of Cyclocarya paliurus (CP) aqueous extract (CPAE) on obesity. Methods SHR.Cg-Leprcp/NDmcr (SHR/cp) rats were used as a model of obesity and metabolic syndrome. Experimental animals were allocated into two groups—control and CPAE (0.5 g/kg)—for a 7-week treatment period. Examinations were performed, including general physiological characteristics, obesity-related biochemical parameters, and insulin-signaling pathway-related proteins in the hypothalamus. Results Treatment with CPAE reduced food intake, body weight, organ weight, fat mass, and body mass index (BMI) in SHR/cp rats. Meanwhile, CPAE also decreased the levels of fasting serum glucose, fasting serum insulin, HOMA-IR, serum free fatty acids, serum malondialdehyde, serum superoxide dismutase, and serum total-glutathione. The levels of phosphorylation of target proteins—including InsR, IRS1, PI3Kp85, Akt, and FoXO1 as well as protein expression of POMC—were significantly upregulated in the hypothalamus, but NPY expression remarkably decreased. Conclusions CPAE has antiobesity, antihypoglycemic, antihypolipidemic, and antioxidant properties. The mechanism responsible for the antiobesity effect of CPAE may be related to suppression of energy intake via regulation of insulin-signaling pathway in the hypothalamus.

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“…GLK in hypothalamic neurons participates in glucose-sensing mechanisms and in triggering counter-regulatory responses in hypoglycemia, 49 while hypothalamic INSRA may have a satiety effect, 50 possibly modulating the AKT-(FOXO1) signaling pathway. 51 FOXO1, also participates in leptin signaling in the brain. 52 Gene expression in response to high continuous levels of prolactin was time-and region-dependent.…”

Section: Discussionmentioning

confidence: 99%

Chronic high prolactin levels impact on gene expression at discrete hypothalamic nuclei involved in food intake

et al. 2020

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To study the pathological effects of continuous hyperprolactinemia on food intake mechanisms we used female mice that lack dopamine D2 receptors in lactotropes (lacDrd2KO). These mice had lifelong hyperprolactinemia, increased food intake, and gradual development of obesity from 5 to 10 months of age. Ongoing endogenous prolactin signaling in lacDrd2KO mice was evidenced by increased basal phosphorylation of STAT5b in hypothalamic areas related to food intake, such as the arcuate (ARN), dorsomedial (DMN), and ventromedial nuclei. In the ARN of young lacDrd2KO mice there were higher Prlr mRNA levels and in obese 10‐month‐old lacDrd2KO mice increased expression of the orexigenic genes Neuropeptide Y (Npy) and Agouti‐related peptide, compared to controls. Furthermore, Npy expression was increased in the DMN, probably contributing to increased food intake and decreased expression of Uncoupling protein‐1 in brown adipose tissue, both events favoring weight gain. Leptin resistance in obese lacD2RKO mice was evidenced by its failure to lower food intake and a dampened response of STAT3 phosphorylation, specifically in the mediobasal hypothalamus. Our results suggest that pathological chronically high prolactin levels, as found in psychiatric treatments or patients with prolactinomas, may impact on specific hypothalamic nuclei altering gene expression, leptin response, and food intake.

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d-chiro-inositol glycan reduces food intake by regulating hypothalamic neuropeptide expression via AKT-FoxO1 pathway

Cited by 12 publications

References 30 publications

The Healing-Promoting Properties of Selected Cyclitols—A Review

The Healing-Promoting Properties of Selected Cyclitols—A Review

Cyclocarya paliurus (Batal.) Ijinskaja Aqueous Extract (CPAE) Ameliorates Obesity by Improving Insulin Signaling in the Hypothalamus of a Metabolic Syndrome Rat Model

Chronic high prolactin levels impact on gene expression at discrete hypothalamic nuclei involved in food intake

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