D-chiro-inositol is more effective than myo-inositol in preventing folate-resistant mouse neural tube defects

Cogram, Patricia; Tesh, S. A.; Tesh, J.M.; Wade, Angie; Allan, Geoffrey; Greene, Nicholas D. E.; Copp, Andrew J.

doi:10.1093/humrep/17.9.2451

Cited by 58 publications

(72 citation statements)

References 42 publications

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“…In addition, supplementation of folic acid does not reduce the NTD rate to zero in any clinical study (4,5), which suggests the existence of nonfolate deficiency-dependent NTDs. This notion is supported by several studies of animal NTD models where folic acid supplementation fails to completely prevent the developmental damage (12,13).…”

mentioning

confidence: 79%

Folic Acid Supplementation Diminishes Diabetes- and Glucose-Induced Dysmorphogenesis in Rat Embryos In Vivo and In Vitro

2005

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Maternal administration of folic acid diminishes the risk of neural tube defects (NTDs) in offspring, but whether folic acid exerts a similar effect in diabetic pregnancy is unknown. The aim was to investigate whether maldevelopment in rat embryos caused by exposure to diabetes in vivo or high-glucose concentrations in vitro is affected by subcutaneous administration of folic acid to the pregnant mother or by adding the compound to the culture medium, respectively. Exposure of embryos to maternal diabetes in vivo or 30 mmol/l glucose in vitro yielded an increased malformation rate (71 and 88% NTD, respectively) and lowered somite number and crown-rump length compared with control embryos. When we injected folic acid into the diabetic pregnant rat, or added 2 mmol/l folic acid to the culture medium with high glucose, the embryonic parameters improved (3 and 5% NTD, respectively). The present work shows that administration of folic acid can diminish diabetes-induced maldevelopment. This suggests that folic acid supplementation may have a role in the prevention of malformations in diabetic pregnancy. Diabetes 54:546 -553, 2005

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confidence: 79%

Folic Acid Supplementation Diminishes Diabetes- and Glucose-Induced Dysmorphogenesis in Rat Embryos In Vivo and In Vitro

2005

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“…Higher concentrations of up to 0.5 mg per day did not significantly influence this result. Furthermore, in a recent study by Cogram et al (2002), a marked reduction (53%) in the frequency of NTDs was observed after oral supplementation of pregnant Curly tail mice with a total of 800 mg/kg b.w. myo-inositol in a twice-daily regimen from ED8.5 to ED10.5.…”

Section: Diet and Supplementsmentioning

confidence: 89%

“…Early studies showed that culturing rat embryos in myo-inositol-deficient medium resulted in cranial NTDs (Cockroft, 1988). Both in vitro and in vivo studies indicated that NTDs in Curly tail (Ct; a mouse model for human NTDs, in which 50 -60% of the offspring have spina bifida and exencephaly [van Straaten and Copp, 2001]), is sensitive to myo-inositol supplementation (Cockroft et al, 1992;Seller, 1994;Greene and Copp, 1997;Cogram et al, 2002). Furthermore, maternal diabetes mellitus is known to increase the risk of NTDs (Goto and Goldman, 1994).…”

Section: Introductionmentioning

confidence: 99%

Phenotype of the neural tube defect mouse model bent tail is not sensitive to maternal folinic acid, myo‐inositol, or zinc supplementation

Franke¹,

Klootwijk²,

Lemmers³

et al. 2003

Birth Defects Research

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“…Total and LDL serum cholesterol (942,944 -947) ; micelle formation, dietary and biliary cholesterol absorption and LDL-cholesterol (948) ; vascular smooth muscle cell hyperproliferation (949) ; immunosuppression associated with excessive physical stress (950) ; anti-inflammatory, anti-pyretic, immunomodulator and anti-diabetic (cited in Brufau et al (942) ); anti-diabetic and hypoglycaemic (951) b-Sitosterol: Growth of colon cancer line (952,953) ; prostate cancer (954) ; carcinogen-induced neoplasia (cited in Wattenberg (110) ); apoptosis (955) through caspase activation (956) Inositols: Chiro-inositol: Insulin, signal transduction and mimetic of insulin action (957) ; type 2 diabetes (245,958 -961) ; ovulatory functions and serum androgen concentrations, blood pressure and plasma TAG (621) ; folate-resistant neural tube defects (962) ; pinitol and glucose metabolism (622) Myo-inositol: Metabolism (963) ; TAG and total lipid liver, hepatic activities of glucose-6-phosphate dehydrogenase, malic enzyme, fatty acid synthetase and citrate cleavage enzyme (242,964) ; Hypotheses for whole-grain cereal protectionconversion into chiro-inositol and precursor for several phospholipids (cited in Larner (957) , Novak et al (965) and Pak et al…”

Section: Appendixmentioning

confidence: 99%

New hypotheses for the health-protective mechanisms of whole-grain cereals: what is beyond fibre?

2010

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Epidemiological studies have clearly shown that whole-grain cereals can protect against obesity, diabetes, CVD and cancers. The specific effects of food structure (increased satiety, reduced transit time and glycaemic response), fibre (improved faecal bulking and satiety, viscosity and SCFA production, and/or reduced glycaemic response) and Mg (better glycaemic homeostasis through increased insulin secretion), together with the antioxidant and anti-carcinogenic properties of numerous bioactive compounds, especially those in the bran and germ (minerals, trace elements, vitamins, carotenoids, polyphenols and alkylresorcinols), are today well-recognised mechanisms in this protection. Recent findings, the exhaustive listing of bioactive compounds found in whole-grain wheat, their content in whole-grain, bran and germ fractions and their estimated bioavailability, have led to new hypotheses. The involvement of polyphenols in cell signalling and gene regulation, and of sulfur compounds, lignin and phytic acid should be considered in antioxidant protection. Whole-grain wheat is also a rich source of methyl donors and lipotropes (methionine, betaine, choline, inositol and folates) that may be involved in cardiovascular and/or hepatic protection, lipid metabolism and DNA methylation. Potential protective effects of bound phenolic acids within the colon, of the B-complex vitamins on the nervous system and mental health, of oligosaccharides as prebiotics, of compounds associated with skeleton health, and of other compounds such as a-linolenic acid, policosanol, melatonin, phytosterols and para-aminobenzoic acid also deserve to be studied in more depth. Finally, benefits of nutrigenomics to study complex physiological effects of the 'whole-grain package', and the most promising ways for improving the nutritional quality of cereal products are discussed. Whole-grain wheat: Bioactive compounds: Physiological mechanisms: Health IntroductionThere is growing evidence that whole-grain cereal products protect against the development of chronic diseases. The most important of these in terms of public health are obesity (1,2) , the metabolic syndrome (3,4) , type 2 diabetes (5,6) , CVD (7) and cancers (8 -12) . Whole-grain cereal consumption has also been shown to be protective against mortality, as was shown with inflammation-related death (i.e. noncardiovascular and non-cancer inflammatory diseases such as, for example, respiratory system diseases) (13) and with cancer and CVD (4,14,15) . These conclusions are supported by the effects of consuming refined cereal products (bread, pasta and rice), as these have been associated with an increased risk of digestive tract, pharynx, larynx and thyroid cancers in northern Italians (16) . However, an association between a lower risk of developing a chronic disease and a high whole-grain cereal consumption does not mean a direct causal relationship and provides no information about the physiological mechanisms involved.These metabolic diseases are related to our daily lifestyle, no...

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D-chiro-inositol is more effective than myo-inositol in preventing folate-resistant mouse neural tube defects

Abstract: D-chiro-inositol offers a safe and effective method for preventing folic acid-resistant NTDs in the curly tail mouse. This raises the possibility of using inositol as an adjunct therapy to folic acid for prevention of NTDs in humans.

Cited by 58 publications

References 42 publications

Folic Acid Supplementation Diminishes Diabetes- and Glucose-Induced Dysmorphogenesis in Rat Embryos In Vivo and In Vitro

Folic Acid Supplementation Diminishes Diabetes- and Glucose-Induced Dysmorphogenesis in Rat Embryos In Vivo and In Vitro

Phenotype of the neural tube defect mouse model bent tail is not sensitive to maternal folinic acid, myo‐inositol, or zinc supplementation

New hypotheses for the health-protective mechanisms of whole-grain cereals: what is beyond fibre?

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