D-dimer level predicts in-hospital mortality in patients with infective endocarditis: A prospective single-centre study

Turak, Osman; Canpolat, Uğur; Özcan, Fırat; Yayla, Çağrı; Mendi, Mehmet Ali; Öksüz, Fatih; Tok, Duran; Tok, Derya; Cagli, Kumral; Gölbaşı, Zehra

doi:10.1016/j.thromres.2014.06.015

Cited by 33 publications

(30 citation statements)

References 42 publications

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“…In our study, we confirmed that elevated Ddimer (> 0.5 mg/L) was a risk factor for death. This result was consistent with those of previous work [32,33]. D-dimer is the degradation of cross-linked fibrin, which represents the activation of coagulation and the fibrinolysis system; it can be used as one of the indicators of thrombosis.…”

Section: Discussionsupporting

confidence: 93%

Clinical characteristics and risk factors for shock and death from E. coli bacteremia in pediatric hematological patients

Wang

Liu

Huang

et al. 2019

J Infect Dev Ctries

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Introduction: The aim of our study was to evaluate the epidemiology, clinical features and risk factors for shock and mortality from Escherichia coli bacteremia among children and adolescents with hematological disorders. Methodology: A retrospective observational study of E. coli bacteremia in the hematology department at Xiangya Hospital from January 2013 to June 2018 was conducted. Clinical characteristics, laboratory results and antimicrobial susceptibility were analysed. Risk factors for shock and mortality were also investigated. Results: Of the 45 strains of E. coli, 73.3% were multidrug-resistant (MDR). Septic shock was observed in 51.1% of patients, and the 30-day all-cause mortality was 22.2%. The risk factors associated with shock were an elevated red blood cell distribution (RDW) value when bloodstream infections (BSIs) occurred (> 15%, OR, 6.840; 95% CI, 1.571 – 29.788) and a lower WBC count (< 300/mm3, OR, 6.761; 95% CI, 1.383 – 33.044). Multivariate analysis showed that only an elevated D-dimer level (> 0.5 mg/L, OR 12.250, 95% CI 1.268 – 118.361) was a risk factor for 30-day mortality. Furthermore, we observed decreases for RDW changes at two time points (neutropenia and BSIs occurred) in the non-shock group and survival group. Conclusions: MDR infections from E. coli bacteremia were common in pediatric hematological patients. In our setting, the laboratory results may serve as a clue for physicians to distinguish patients at higher risk for shock and mortality. Furthermore, RDW could be used as a biomarker to elucidate potential disorders in hematological patients.

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Section: Discussionsupporting

confidence: 93%

Clinical characteristics and risk factors for shock and death from E. coli bacteremia in pediatric hematological patients

Wang

Liu

Huang

et al. 2019

J Infect Dev Ctries

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“…In the present study, our result showed that the serum D-dimer level was an independent risk factor for in-hospital death (relative risk =6.51, 95% CI: 3.06–13.83) and 1-year mortality (HR =3.48, 95% CI 2.07–5.85; P =0.001 for univariate analysis; and HR =1.96, 95% CI 1.05–3.65; P =0.035 for multivariate analysis) for AECOPD. Many studies have reported that the D-dimer was an independent predictor for cardiovascular and all-cause death among elderly persons 10,13,15,20. Our study results were consistent with the retrospective study reported by Oren Fruchter,10 which showed that D-dimer level examined on admission could be used as a predictive biomarker for short-and long-term mortality for AECOPD 10…”

Section: Discussionsupporting

confidence: 91%

Prognostic role of D-dimer for in-hospital and 1-year mortality in exacerbations of COPD

Zhou

et al. 2016

COPD

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Background and objectiveSerum D-dimer is elevated in respiratory disease. The objective of our study was to investigate the effect of D-dimer on in-hospital and 1-year mortality after acute exacerbations of chronic obstructive pulmonary disease (AECOPD).MethodsUpon admission, we measured 343 AECOPD patients’ serum D-dimer levels and arterial blood gas analysis, and recorded their clinical characteristics. The level of D-dimer that discriminated survivors and non-survivors was determined using a receiver operator curve (ROC). The risk factors for in-hospital mortality were identified through univariate analysis and multiple logistic regression analyses. To evaluate the predictive role of D-dimer for 1-year mortality, univariate and multivariate Cox regression analyses were performed.ResultsIn all, 28 patients died, and 315 patients survived in the in-hospital period. The group of dead patients had lower pH levels (7.35±0.11 vs 7.39±0.05, P<0.0001), higher D-dimer, arterial carbon dioxide tension (PaCO2), C-reactive protein (CRP), and blood urea nitrogen (BUN) levels (D-dimer 2,244.9±2,310.7 vs 768.2±1,078.4 µg/L, P<0.0001; PaCO2: 58.8±29.7 vs 46.1±27.0 mmHg, P=0.018; CRP: 81.5±66, P=0.001; BUN: 10.20±6.87 vs 6.15±3.15 mmol/L, P<0.0001), and lower hemoglobin levels (118.6±29.4 vs 128.3±18.2 g/L, P=0.001). The areas under the ROC curves of D-dimer for in-hospital death were 0.748 (95% confidence interval (CI): 0.641–0.854). D-dimer ≥985 ng/L was a risk factor for in-hospital mortality (relative risk =6.51; 95% CI 3.06–13.83). Multivariate logistic regression analysis also showed that D-dimer ≥985 ng/L and heart failure were independent risk factors for in-hospital mortality. Both univariate and multivariate Cox regression analyses showed that D-dimer ≥985 ng/L was an independent risk factor for 1-year death (hazard ratio (HR) 3.48, 95% CI 2.07–5.85 for the univariate analysis; and HR 1.96, 95% CI 1.05–3.65 for the multivariate analysis).ConclusionD-dimer was a strong and independent risk factor for in-hospital and 1-year death for AECOPD patients.

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“…Fibrinogen turns into fibrin which participates in the formation of a thrombus. Increased circulating D-dimer levels are reported to be correlated with adverse outcomes in various clinical settings (15). The detection interval of the D-dimer test in our hospital is 0.01-16 µg/mL, and therefore only D-dimer levels above 16 µg/mL were counted in this study.…”

Section: Discussionmentioning

confidence: 97%

Inflammation is related to preoperative hypoxemia in patients with acute Stanford type A aortic dissection

Duan¹,

Zhao²,

Lu³

et al. 2018

J. Thorac. Dis.

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D-dimer level predicts in-hospital mortality in patients with infective endocarditis: A prospective single-centre study

Cited by 33 publications

References 42 publications

Clinical characteristics and risk factors for shock and death from E. coli bacteremia in pediatric hematological patients

Clinical characteristics and risk factors for shock and death from E. coli bacteremia in pediatric hematological patients

Prognostic role of D-dimer for in-hospital and 1-year mortality in exacerbations of COPD

Inflammation is related to preoperative hypoxemia in patients with acute Stanford type A aortic dissection

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