D-dimer levels in assessing severity and clinical outcome in patients with community-acquired pneumonia. A secondary analysis of a randomised clinical trial

Snijders, Dominic; Schoorl, Margreet; Schoorl, Marianne; Bartels, P. C. M.; Werf, Tjip S. van der; Boersma, Wim

doi:10.1016/j.ejim.2011.10.019

Cited by 91 publications

(94 citation statements)

References 23 publications

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“…DD increases had some degree of correlation with the CURB-65 score increases (p < 0.008) which is consistent with previous findings, as published by Snijders et al 6 In fact, the addition of D-dimer has slightly increased the performance of CURB-65, concerning the severity of CAP. On the other hand, no correlation was found with PSI score, which contradicts results from other studies, such as Ribelles et al 5 The relationship between DD and mortality was also assessed.…”

supporting

confidence: 93%

“…In turn, the immunosuppressive drugs induce different disorders, like arterial hypertension, chronic kidney failure, diabetes, hyperlipidemia, osteoporosis, and infections (which are the second cause of mortality after BOS), and increase the risk of malignancies, mainly skin cancers, post-transplant lymphoproliferative disorders and Kaposi's sarcoma. 6 The authors here describe the data about complications related to LT and QoL of patients followed in LT outpatient clinic of Centro Hospitalar São João. Of the 83 patients, 37 (30 LT recipients and 7 LT candidates) completed the Medical Outcomes Study Short Form-36 (MOS SF-36), the London Chest Activity of Daily Living (LCADL) questionnaire and the Hospital Anxiety and Depression Scale (HADS).…”

Section: Lung Transplant: Complications and Quality Of Lifementioning

confidence: 99%

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Prognostic value of plasma D-dimer level in adults with community-acquired pneumonia: A prospective study

Duarte

Castro

Silva

et al. 2015

Revista Portuguesa de Pneumologia (English Edition)

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supporting

confidence: 93%

Section: Lung Transplant: Complications and Quality Of Lifementioning

confidence: 99%

Prognostic value of plasma D-dimer level in adults with community-acquired pneumonia: A prospective study

Duarte

Castro

Silva

et al. 2015

Revista Portuguesa de Pneumologia (English Edition)

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“…The authors found that DD elevation was a negative prognostic factor in CAP: DD 256-1000 ng/mL was combined with 2-3 fold higher mortality rate and DD > 1000 ng/mL -with 5 fold higher mortality rate [26]. Snijders et al and Agapakis et al found DD concentration significantly higher in patients with severe CAP (CURB-65 score 3-5) comparing to the others [27,28].…”

Section: Discussionmentioning

confidence: 94%

Non-High Risk PE in the Patients with Acute or Exacerbated Respiratory Disease: The Value of the Algorithm Based on D-Dimer Evaluation and Revised Geneva Score

Szturmowicz¹,

Kacprzak²,

Wyrostkiewicz³

et al. 2015

Advances in Respiratory Medicine

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Introduction: The diagnostic algorithm of non-high risk pulmonary embolism (PE) is based on probability scoring systems and plasma D-dimer (DD) assessment. The aim of the present study was to investigate the efficacy of Revised Geneva Scoring (RGS) and DD testing for the excluding of non-high risk PE, in the patients admitted to the hospital due to acute respiratory diseases. Material and methods:The consecutive patients, above 18 years of age, referred to the department of lung diseases, entered the study. The exclusion criteria were: the pregnancy and the suspicion of high risk PE. Plasma DD was measured with quick ELISA test, VIDAS D-dimer New, bioMerieux, France. Multislice computed tomography angiography was performed in all of the patients. Results: 153 patients, median age 65 (19−88) years entered the study. The probability of PE was: low -in 58 patients (38%), intermediate -in 90 (59%), high -in 5 (3%). DD < 500 ng/ml was found in 12% of patients with low and intermediate probability of PE. PE was recognized in 10 out of 153 patients (7%). None of the patients with DD < 500 ng/ml was diagnosed with PE (NPV 100%). Median DD value was significantly higher in PE patients comparing to non-PE (4500 ng/ml and 1356 ng/ml respectively, p = 0.006). Conclusion: In the group of the patients with acute respiratory symptoms, low or intermediate clinical probability scoring combined with normal DD had a high NPV in excluding PE. Nevertheless, such approach was not very effective, as the increased DD was noted in 88% of the examined population.

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“…That said, D Dimer levels reflect the pathological role coagulation and fibrinolysis play in development acute lung injury. Levels increase in patients with severe CAP at high-risk mortality (97 (97,98).…”

Section: Novel Biomarkersmentioning

confidence: 99%

Predictors of treatment failure and clinical stability in patients with community acquired pneumonia

Morley¹,

Torres²,

Cillóniz³

et al. 2017

Ann. Transl. Med.

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Community acquired pneumonia (CAP) is the leading infectious cause of mortality worldwide with approximately 10% of patients hospitalized requiring intensive care unit (ICU) admission. The ability to predict clinical stability (CS) and treatment failure (TF) enables the clinician to alter antibiotics appropriately, facilitate a timely ICU admission, or arrange a suitable discharge. The detection of CS and TF can be difficult and changes in clinical signs may be subtle or delayed. Thus clinical scores and biomarkers are routinely used to identify severity and monitor clinical progression. The evidence, however, is vast and the definitive role of these systems is at times difficult to elucidate. The aim of this review is to analyse the current literature and to provide a rational and clinically focused view of the predictive utility of various systems used to identify CS and TF in CAP.

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D-dimer levels in assessing severity and clinical outcome in patients with community-acquired pneumonia. A secondary analysis of a randomised clinical trial

Cited by 91 publications

References 23 publications

Prognostic value of plasma D-dimer level in adults with community-acquired pneumonia: A prospective study

Prognostic value of plasma D-dimer level in adults with community-acquired pneumonia: A prospective study

Non-High Risk PE in the Patients with Acute or Exacerbated Respiratory Disease: The Value of the Algorithm Based on D-Dimer Evaluation and Revised Geneva Score

Predictors of treatment failure and clinical stability in patients with community acquired pneumonia

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