D-dimer levels positively correlate with B-type natriuretic peptide levels in patients with atrial fibrillation

Sadanaga, Tsuneaki; Mitamura, Hideo; Fukuda, Keiichi; Ogawa, Satoshi

doi:10.1016/j.ijcard.2012.04.079

Cited by 11 publications

(15 citation statements)

References 7 publications

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“…[ 6 ] D-dimer level increases with age, and is elevated when AF has long been recognized. [ 7 – 9 ] In recent years, a researcher also reported that D-dimer level has a positive relationship with BNP. [ 9 , 10 ] Furthermore, some prospective studies have confirmed that D-dimer level can predict the occurrence of thromboembolic and cardiovascular events, such as acute myocardial infarction and acute aortic dissection, in atrial fibrillation patients, particularly patients complicated with clinical risk factors.…”

Section: Introductionmentioning

confidence: 99%

The association of high D-dimer level with high risk of ischemic stroke in nonvalvular atrial fibrillation patients

You

Tang

2018

Medicine

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This study aimed to explore the relationship of D-dimer level with the risk stratification of ischemic stroke, and determine whether high D-dimer levels could be used as a risk factor of ischemic stroke in patients with nonvalvular atrial fibrillation (NVAF).This single-center, retrospective study recruited NVAF patients who did not undergo anticoagulant therapy. These patients were divided into 2 groups: ischemic stroke group and no-stroke group. The medical records of each patient were reviewed, demographic and clinical analyses were performed, and the laboratory results were summarized.A total of 323 eligible in-patients with NVAF, who did not receive anticoagulant therapy, were recruited (206 male and 117 female patients, median age was 75.18 ± 10.46 years old). Among these patients, 78 patients suffered from acute ischemic stroke. D-dimer level increased with age, and was positively correlated with the risk stratification of stroke, CHADS2 score (rs = 0.441, P < .001), and CHA2DS2-VASC score (rs = 0.412, P < .001), even after adjustment for age and gender (rs = 0.422, P < .001). The difference in baseline D-dimer level between these 2 groups was not statistically significant (0.70 vs 0.66 mg/L, P = .330), but this significantly increased when patients suffered from stroke (1.34 vs 0.70 mg/L, P < .001). The D-dimer level after stroke (≥6 months) was also higher than the baseline (1.16 vs 0.68 mg/L, P = .514) in 6 months, and this level nearly returned to baseline level after one year (0.69 vs 0.68 mg/L, P = .158). However, logistic regression revealed that only the D-dimer level at stroke onset and OMI were independent risk factors for ischemic stroke (P < .001), while the increase from baseline D-dimer levels was not an independent risk factor (P = .125).D-dimer level is positively correlated with the risk stratification of ischemic stroke, but has no predictive value on the occurrence of ischemic stroke in patients with NVAF.

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Section: Introductionmentioning

confidence: 99%

The association of high D-dimer level with high risk of ischemic stroke in nonvalvular atrial fibrillation patients

You

Tang

2018

Medicine

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“…In our present study, we performed a post hoc analysis of the results of our previous study [10]. Briefly, 59 patients for whom BNP and D‐dimer levels were determined on the same day and who had not started warfarin therapy were included.…”

Section: Methodsmentioning

confidence: 99%

“…The statistical software package JMP (version 9, SAS Institute, Cary, NC, USA) was used for the analyses. The cutoff values for D‐dimer and BNP levels were set at 0.5 μg/mL and 100 pg/mL, respectively, according to previous reports [6,10].…”

Section: Methodsmentioning

confidence: 99%

High B‐type natriuretic peptide levels predict a hypercoagulable state in otherwise low‐risk patients with atrial fibrillation

Sadanaga

Mitamura

2013

Journal of Arrhythmia

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a b s t r a c tThe D-dimer and B-type natriuretic peptide (BNP) levels in relation to CHADS 2 and CHA 2 DS 2 -VASc scores in 59 patients with atrial fibrillation who were not receiving anticoagulant therapy were analyzed. Among 19 patients with CHADS 2 scores of 0-1, 3 of the 7 patients with elevated BNP levels also had elevated D-dimer levels. Among 8 patients with CHA 2 DS 2 -VASc scores of 1, 2 of the 3 patients with elevated BNP levels also had elevated D-dimer levels. Therefore, D-dimer levels can be elevated in low-risk patients when BNP levels are high, and anticoagulation therapy should be considered for these patients.

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“…415 AF-related AIS patients with pneumonia were included in the study, 211 patients were female(52.45%) and 184 patients were male (47.55%), with an average age of 67.62±9.84 years old (ranging from 40 to 93 years old), median NIHSS score was 11 (7)(8)(9)(10)(11)(12)(13)(14), medians international standard ratio (INR) was 1.36(1.09-1.95). 82 patients were treated with anticoagulation, medians D-dimer value was 1.9mg/l (1.2-3.0mg/l).…”

Section: Patient Characteristicsmentioning

confidence: 99%

“…AF leads to decreased ow in the left atrial appendage and the atrium, which combine with platelet activation and endothelial dysfunction, increase coagulation activity and lead to stroke. Studies had shown that patients with AF could increase D-dimer levels [6][7][8], and higher D-dimer levels could increase risk of future cerebrovascular and cardiovascular events [9][10][11], increased D-dimer levels have been reported to be proportional to the severity of stroke. In addition, D-dimer may re ect the effect of infection on coagulation.…”

Section: Introductionmentioning

confidence: 99%

Plasma D-Dimer Level is Associated with Clinical Outcomes in Patients with Atrial Fibrillation Related Acute Ischemic Stroke after Pneumonia

et al. 2020

Preprint

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Objectives: Pneumonia is related to poor prognosis in acute ischemic stroke (AIS), and its risk might be higher in atrial fibrillation (AF) related AIS with elevated plasma D-dimer. The aim of our study was to investigate the prognostic value of D-dimer for predicting clinical outcome of AF-related AIS with pneumonia. Method: AF-related AIS patients with pneumonia were prospectively enrolled. Receiver operating characteristic (ROC) curve was used to determine the optimal D-dimer point for 3-month mortality and death/severe disability. The associations between the D-dimer and 3-month mortality and death/severe disability were assessed by multivariable logistic regression analysis. Results: A total of 415 patients were enrolled in this study. ROC curve analysis showed that the optimal cut point of D-dimer for 3-month death/severe disability and mortality were D-dimer≥2.35mg/l and D-dimer≥3.35mg/l, respectively. Multivariable logistic regression analysis showed that D-dimer≥2.35mg/l(OR 5.95, 95% CI: 3.09-11.45, P＜0.001), higher NIHISS score(OR:1.53, 95% CI: 1.38–1.68, P＜0.001) were associated with increased risk of 3-month death/severe disability), and anticoagulant was associated with decreased risk of death/severe disability (OR:0.16, 95% CI: 0.07-0.35, P＜0.001). Higher NIHISS score(OR:1.56, 95% CI: 1. .37–1.77, P＜0.001), higher age(OR 1.06, 95% CI: 1.01–1.11, P=0.019), D-dimer≥3.35mg/l (OR 7.85, 95% CI: 3.21-19.21, P=0.001)were associated with increased risk of 3-month mortality.Conclusions: AF-related AIS patients with concurrent high D-dimer and pneumonia increased risk of 3-month mortality and death/severe disability, plasma D-dimer may have predictive value in outcome after AF-related AIS with pneumonia.

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D-dimer levels positively correlate with B-type natriuretic peptide levels in patients with atrial fibrillation

Cited by 11 publications

References 7 publications

The association of high D-dimer level with high risk of ischemic stroke in nonvalvular atrial fibrillation patients

The association of high D-dimer level with high risk of ischemic stroke in nonvalvular atrial fibrillation patients

High B‐type natriuretic peptide levels predict a hypercoagulable state in otherwise low‐risk patients with atrial fibrillation

Plasma D-Dimer Level is Associated with Clinical Outcomes in Patients with Atrial Fibrillation Related Acute Ischemic Stroke after Pneumonia

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