D-Dimer Predicts Long-Term Cause-Specific Mortality, Cardiovascular Events, and Cancer in Patients With Stable Coronary Heart Disease

Simes, John; Robledo, Kristy; White, Harvey D.; Espinoza, David; Stewart, Ralph; Sullivan, David; Zeller, Tanja; Hague, Wendy; Nestel, Paul J.; Glasziou, Paul; Keech, Anthony; Elliott, John; Blankenberg, Stefan; Tonkin, Andrew; Investigators, Lipid Study

doi:10.1161/circulationaha.117.029901

Cited by 111 publications

(113 citation statements)

References 59 publications

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“…D‐dimer plays an important role in VTE exclusion, acute aortic dissection, DIC diagnosis, and other clinical settings, which has been well reviewed previously . Furthermore, because of the close relationship between coagulation, inflammation, and endothelial injury, elevation of D‐dimer level is also observed in patients with infection, surgery or trauma, malignance, and other nonthrombotic diseases …”

Section: D‐dimer Measurement and Its Traditional Applicationmentioning

confidence: 96%

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Use of D‐dimer in oral anticoagulation therapy

Zhang

Long

Xiao

et al. 2018

Int J Lab Hematology

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Individualized anticoagulation management and improvement of the safety and effectiveness of oral anticoagulant have always been the focus of clinicians' attention. D‐dimer, a sensitive marker of thrombosis and coagulation activation, is not only traditionally used in the diagnosis of venous thromboembolism, acute aortic dissection, and disseminated intravascular coagulation but can also be used as a helpful marker in the management of oral anticoagulant, including evaluating the anticoagulation quality, predicting clinical outcomes, and determining the optimal duration and intensity of anticoagulation.

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Section: D‐dimer Measurement and Its Traditional Applicationmentioning

confidence: 96%

“…7-10 Furthermore, because of the close relationship between coagulation, inflammation, and endothelial injury, elevation of D-dimer level is also observed in patients with infection, surgery or trauma, malignance, and other nonthrombotic diseases. 7,[19][20][21][22]…”

mentioning

confidence: 99%

Use of D‐dimer in oral anticoagulation therapy

Zhang

Long

Xiao

et al. 2018

Int J Lab Hematology

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“…Circulating D‐dimer is also elevated in patients with liver disease, coronary artery disease and other cardiovascular diseases, cancer, trauma, pregnancy, infections, inflammatory diseases, severe renal disease, recent surgical procedures, and advanced age as summarized in Table . However, the D‐dimer elevation in these conditions is less specific than for DVT/PE.…”

Section: Common Uses Of D‐dimer Assaysmentioning

confidence: 99%

“…Despite this volume of data, its clinical value and significance for many indications remain controversial . Many attempts have been made to increase clinical utility of the D‐dimer test in a variety of other medical conditions, including combining D‐dimer with other laboratory tests and clinical algorithms …”

Section: Introductionmentioning

confidence: 99%

The D‐dimer assay

2019

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D-dimer is an indirect marker of fibrinolysis and fibrin turnover; this molecule exhibits unique properties as a biological marker of hemostatic abnormalities as well as an indicator of intravascular thrombosis. D-dimer is a soluble fibrin degradation product that results from the systematic degradation of vascular thrombi through the fibrinolytic mechanism. Because of this, the D-dimer serves as a valuable marker of activation of coagulation and fibrinolysis in a number of clinical scenarios. Most commonly, D-dimer has been extensively investigated for excluding the diagnosis of venous thromboembolism (VTE) and is used routinely for this indication. In addition, D-dimer has been evaluated for determining the optimal duration of anticoagulation in VTE patients, for diagnosing and monitoring disseminated intravascular coagulation, and for monitoring other conditions in which the patient is at high risk of bleeding or thrombosis. Limitations of the assay include D-dimer elevation in a constellation of clinical scenarios (age, pregnancy, and cancer) and lack of clinical standardization.

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“…D-Dimer is a speci c degradation product under the action of plasmin after cross-linking of brin, and its increased level indicates that the body's secondary brinolytic activity is enhanced, re ecting the body's hypercoagulable and brinolytic state, and can be used for diagnosis Thromboembolic disease. And previous studies have shown that the elevation of D-Dimer is an important independent and persistent risk factor for cardiovascular events and cancer events [17] , as well as an early sign of impending MAS in febrile patients with active rheumatism and monitoring indicator for severe infections [18][19] . In this study, a ROC curve was used to analyze the diagnostic e ciency of various markers for EBV-HLH.…”

Section: Resultsmentioning

confidence: 98%

Clinical Warning of Hemophagocytic Syndrome Caused by Epstein-barr Virus

Shi

Chu

et al. 2020

Preprint

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Objectives This study aimed to compare the clinical features and laboratory tests of infectious mononucleosis (IM) and hemophagocytic syndrome (HLH) caused by Epstein-Barr virus (EBV) in 1-3-year-old children and to explore the risk factor of HLH caused by EBV (EBV-HLH). Methods The clinical data of 92 children with EBV infection admitted in our hospital from 2011 to 2019 were collected; 61 cases were diagnosed as EBV-IM, and 31 cases were diagnosed as EBV-HLH. The subjects’ clinical manifestations and laboratory tests were analyzed retrospectively. Results Compared with EBV-IM patients, EBV-HLH patients had longer durations of fever, both before hospitalization and overall, and a higher probability of hepatomegaly. The levels of ALT, AST, LDH, TG, SF, D-Dimer and the plasma EBV DNA load of EBV-HLH patients were significantly higher than those of EBV-IM patients. The absolute values of CD3+, CD4+, CD8+, NK, and CD3-CD19+ cells and IgA and IgM levels of EBV-HLH patients were significantly lower than those of EBV-IM patients. The plasma EBV DNA load was positively correlated with the PT, TT, α-HBDH, AST, LDH, CK, Scr, BUN, UA, TG, and CRP levels in EBV-HLH patients, and the plasma EBV DNA load was positively correlated with the D-Dimer level in the EBV-IM patients. Among the 10 different potential markers, at the cut-off point of 1721.500 µg/L, the sensitivity and specificity of D-Dimer was 88.90% and 90.20%, respectively. Conclusion The D-Dimer level may be a good prognostic indicator of EBV-HLH caused by EBV.

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D-Dimer Predicts Long-Term Cause-Specific Mortality, Cardiovascular Events, and Cancer in Patients With Stable Coronary Heart Disease

Cited by 111 publications

References 59 publications

Use of D‐dimer in oral anticoagulation therapy

Use of D‐dimer in oral anticoagulation therapy

The D‐dimer assay

Clinical Warning of Hemophagocytic Syndrome Caused by Epstein-barr Virus

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