D-Dímero Elevado Em Pacientes Com Covid-19: Relato De Uma Seguimento Clínico E Laboratorial Em 6 Casos Confirmados

Rocha, M. E. G.; Chagas, V. M.; Carvalho, Luiz Guilherme; S., V. R.; Aroucha, A. Q. M. S.; Correia, M. C. B.; Costa, Manuela

doi:10.1016/j.htct.2020.10.892

Cited by 3 publications

(4 citation statements)

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“…It was observed that of the patients in the present study, 27.59% had Ddimer levels six times higher than the reference value, while 17.24% had values ten times higher than the established reference value, which was 500 ng/dL. Elevation of the D-dimer is associated with an intense inflammatory reaction from the viral infection, as well as a greater risk of thromboembolic events during infection with the new coronavirus, which worsens the prognosis and increases the death rate (ROCHA et al, 2020).…”

Section: Discussioncontrasting

confidence: 44%

Prognostic analysis and clinical and nutritional characteristics of critical Covid-19 patients

et al. 2023

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The Covid-19 pandemic represented a challenge for health systems, in large part due to the high mortality rate of the disease in older population, multiform clinical manifestations and prognosis related to nutritional diagnosis and biochemical profile of patients. Objective: to correlate Covid-19 patients admitted to an Intensive Care Unit (ICU) with laboratory tests, anthropometric data and the clinical outcome of the disease. Methodology: an epidemiological and cross-sectional study was performed using secondary databases, analyzing the laboratory (hemoglobin, hematocrit, leukocytes, rods, platelets, creatinine, d-dimer, oxaloacetic transaminase, pyruvic transaminase and C-reactive protein) and nutritional (upper arm circumference, calf circumference and body mass index) parameters of Covid-19 patients admitted to the ICU between March 2020 and March 2021. Sociodemographic, laboratory and clinical data were collected from hospitalized Covid-19 patients in the hospital. Results: inverse correlations were observed between age and anthropometric indicators. The use of a greater number of medications (average 2.1) was associated with lower final Body Mass Index (average 29.2 kg/m²) and arm circumference (average 32.3 cm) values. Patients who died were older, had shorter hospital stays, higher creatinine levels and lower baseline anthropometric indicators. Conclusions: older patients had lower anthropometric values. Patients with chronic diseases had a worse prognosis in the evolution of Covid-19.

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Section: Discussioncontrasting

confidence: 44%

Prognostic analysis and clinical and nutritional characteristics of critical Covid-19 patients

et al. 2023

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“…It was also observed that critically ill patients hospitalized the ICU had significantly higher values for D-dimer markers. Nonetheless, changes in relation to D-dimer can be predictors of severity and reflect in poor prognosis, mainly associated with thrombotic events [ 24 ]. A prospective cohort study demonstrated a 10% increase in mortality risk for every 10% increase in interleukin (IL)−6 or D-dimer levels [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

“…Finally, ROS and D-dimer presented a relationship, since they were associated with an increased risk of needing to be hospitalized in the ICU. This relationship appear, once, the immune response leads to excessive production and accumulation of ROS, that cause clinical signs characteristic of COVID-19, such as decreased oxygen saturation, vasoconstriction, elevated cytokines, alteration of hemoglobin properties, cardiac and/or renal injury and enhanced D-dimer [ 32 ], that reflects poor prognosis, mainly associated with thrombotic events [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of oxidative stress level: reactive oxygen species, reduced glutathione, and D-dimer in patients hospitalized due to COVID-19

Roessler,

de Oliveira,

de Oliveira Portella

et al. 2023

Redox Report

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Elevated D-dimer levels at hospital admission may also indicate a higher likelihood of progressing to a severe or critical state. This study aimed to assess reactive oxygen species (ROS), non-enzymatic antioxidant reduced glutathione (GSH), and D-dimer levels in COVID-19 patients upon admission, examining their association with mortality outcomes. Data was collected from the medical records of 170 patients hospitalized in a referral hospital unit between March 2020 and December 2021. Patients were divided into two groups: the ward bed group ( n = 87), comprising 51% with moderate clinical conditions, and the intensive care unit (ICU) group ( n = 83), comprising 49% with severe conditions. The mean age was 59.4 years, with a male predominance of 52.4%. The overall death rate was 43%, with 30.6% in the moderate group and 69.4% in the severe group. The average time from symptom onset to hospitalization was 6.42 days. Results showed that non-survivors had high D-dimer and ROS counts, longer ICU stays, and worse saturation levels at admission. In conclusion, elevated ROS and D-dimer levels may contribute to worse outcomes in critically ill patients, potentially serving as specific and sensitive predictors of poor outcomes upon admission.

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“…(9) Los factores de riesgo para desarrollar TEP son algo inespecíficos y muchos de estos representarán un riesgo franco para la presentación de TEP asociada a COVID-19, sin embargo, varían entre pacientes y es por esto que no se puede generalizar quienes van a presentar esta complicación y quienes van a ser esquivos a la misma, a pesar de esto se debe conocer dichos factores y tenerlos en cuenta en todo momento. (6,10) Existen múltiples factores de riesgo con influencia en la presentación de TEP relacionado a COVID-19, así por mencionar algunos se sabe que los pacientes que precisan ingreso a UCI tienen un mayor riesgo de desarrollar TEP que aquellos pacientes que se mantienen en planta de hospitalización, (11,12) el aumento de dímero D (DD) se ha visto también asociado con patología trombótica además de relacionarse a un mayor índice de mortalidad, así también la presencia de comorbilidades como la obesidad aumenta el riesgo de contagio y la necesidad de intubación, (11,13,14) incluso a cierta edad se aumenta el riesgo embolias venosas y debe ser considerado como un factor a tomar en cuenta. (15,16) Esta investigación busca dar a conocer algunos de los factores de riesgo que se asocian al desarrollo de TEP en pacientes con COVID-19, con el fin de contribuir a integrar el conocimiento científico como base teórica para el desarrollo de estrategias de prevención y con el objetivo de llegar no solo al conocimiento del personal de salud sino además de la población en general y así poder garantizar una mayor supervivencia de los pacientes además de evitar el colapso de los sistemas de salud como fue evidente en un inicio de la pandemia.…”

Section: Introductionunclassified

Risk factors associated with the development of pulmonary thromboembolism in adult patients diagnosed with COVID-19

Gaona

Cajamarca

Palomeque

et al. 2022

Salud, Ciencia y Tecnología

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Introducción: La infección por COVID-19 abarca varias manifestaciones clínicas que van desde tos, fiebre, mialgias, disnea, fatiga y rinorrea hasta una infección asintomática en algunos de los casos, a esto se suma y gana importancia como una complicación del COVID-19 las enfermedades de la coagulación entre las que encontramos el tromboembolismo pulmonar (TEP), de hecho se ha logrado identificar pacientes que han llegado a fallecer por esta causa asociada a la infección por SARS-CoV-2.Objetivo: Describir los factores de riesgo asociados al desarrollo de tromboembolismo pulmonar en pacientes adultos con diagnóstico de COVID-19.Métodos: revisión bibliográfica narrativa en donde se incluyó meta-análisis, revisiones sistemáticas, artículos de revisión y artículos de investigación publicadas en PubMed y Web of Science entre los años 2020-2022.Conclusiones: se determinó que existen factores de riesgo que propician el desarrollo de TEP asociado a COVID-19, de los cuales mencionamos algunos como la edad, el ingreso a unidades de cuidados intensivos (UCI) e incluso el sexo del paciente, cabe recalcar que cada uno de estos se encuentra relacionado en mayor o menor medida por lo que deben ser considerados y asociados teniendo en cuenta esa distinción.

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D-Dímero Elevado Em Pacientes Com Covid-19: Relato De Uma Seguimento Clínico E Laboratorial Em 6 Casos Confirmados

Cited by 3 publications

References 0 publications

Prognostic analysis and clinical and nutritional characteristics of critical Covid-19 patients

Prognostic analysis and clinical and nutritional characteristics of critical Covid-19 patients

Evaluation of oxidative stress level: reactive oxygen species, reduced glutathione, and D-dimer in patients hospitalized due to COVID-19

Risk factors associated with the development of pulmonary thromboembolism in adult patients diagnosed with COVID-19

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