2009
DOI: 10.1007/s00253-009-1870-6
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d-Galacturonic acid catabolism in microorganisms and its biotechnological relevance

Abstract: D-Galacturonic acid is the main constituent of pectin, a naturally abundant compound. Pectin-rich residues accumulate when sugar is extracted from sugar beet or juices are produced from citrus fruits. It is a cheap raw material but currently mainly used as animal feed. Pectin has the potential to be an important raw material for biotechnological conversions to fuels or chemicals. In this paper, we review the microbial pathways for the catabolism of D-galacturonic acid that would be relevant for the microbial c… Show more

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Cited by 128 publications
(120 citation statements)
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“…S. flexneri does not use exogenous gluconate as a carbon source, but carbon could enter this pathway from glucose or glucose-phosphate. In E. coli, the EntnerDoudoroff pathway is necessary for colonization initiation and maintenance in a mouse model (45). The Entner-Doudoroff pathway also contributes to colonization and production of disease by Vibrio cholerae, as an edd mutant strain failed to colonize in a mouse model or to induce fluid accumulation in ligated rabbit ileal loops (53).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…S. flexneri does not use exogenous gluconate as a carbon source, but carbon could enter this pathway from glucose or glucose-phosphate. In E. coli, the EntnerDoudoroff pathway is necessary for colonization initiation and maintenance in a mouse model (45). The Entner-Doudoroff pathway also contributes to colonization and production of disease by Vibrio cholerae, as an edd mutant strain failed to colonize in a mouse model or to induce fluid accumulation in ligated rabbit ileal loops (53).…”
Section: Discussionmentioning
confidence: 99%
“…5), indicating a lack of metabolism of these compounds or inhibition by their metabolic product. In E. coli, these substrates are ultimately converted to 2-keto-3-deoxy-D-gluconic acid, which is phosphorylated by ATP to yield 2-keto-3-deoxy-6-phosphogluconic acid (KDPG), the substrate of Eda (44,45). Accumulation of KDPG would be toxic to the bacteria.…”
Section: Figmentioning
confidence: 99%
“…At present, these residues are mainly used as cattle feed. However, since energy-consuming drying and pelletizing of the residues is required to prevent them from rotting, it is not always economical to process the residues, and it is desirable to find alternative uses.Various microbes which live on decaying plant material have the ability to catabolize D-galacturonate using various, completely different pathways (19). Eukaryotic microorganisms use a reductive pathway in which D-galacturonate is first reduced to L-galactonate by an NAD(P)H-dependent reductase (12,17).…”
mentioning
confidence: 99%
“…Various microbes which live on decaying plant material have the ability to catabolize D-galacturonate using various, completely different pathways (19). Eukaryotic microorganisms use a reductive pathway in which D-galacturonate is first reduced to L-galactonate by an NAD(P)H-dependent reductase (12,17).…”
mentioning
confidence: 99%
“…Pectin is found in the cell wall of plants and is often discarded as waste in sugar-beet pulp, apple pomace and citrus peel (Richard & Hilditch, 2009). A number of research groups are interested in redirecting this biomass waste stream for the production of fuel and bulk chemicals (Benz et al, 2014).…”
Section: Introductionmentioning
confidence: 99%