D-Galaktoz ile İndüklenen Farelerde Yaşlanma Modelinin Nefropatisi Üzerine Mirisitrin ve Vitamin E’nin Koruyucu Etkileri

Radmehr, Vahid; Ahangarpour, Akram; Khorsandi, Layasadat; Omidi, Mina

doi:10.18678/dtfd.994776

Cited by 3 publications

(3 citation statements)

References 32 publications

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“…D-Gal causes aging progression and nephropathy in the brain, kidney, and liver. It also induces oxidative stress by increasing lipid peroxidation [41]. In the present study, the effects of TQ on the changes caused by AlCl3+D-Gal in the testicular tissue of rats, which were administried to create an experimental Alzheimer's model, were investigated.…”

Section: Discussionmentioning

confidence: 96%

Effects of thymoquinone against D- galactose and aluminum chloride induced testicular dysfunction in rats.

AKARSU,

ÇETİN

2023

Türk Doğa Ve Fen Dergisi

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Alzheimer's disease affects all tissues negatively. In this study, it was aimed to determine the effects of TQ on testicular toxicity in rats with experimental Alzheimer's disease. In the study, 33 Wistar Albino rats weighing 190-230 gr were used. Rats were 11 rats in each group; were divided into 3 equal groups as control, ALZ and ALZ+TQ. The control group was given saline by IP route for 28 days daily. The ALZ group was given 60 mg/kg D-gal + 40 mg/kg AlCl3 IP for 28 days daily. The ALZ+TQ group was given 60 mg/kg D-gal + 40mg/kg AlCl3 for 28 days by IP + 20 mg/kg TQ by oral gavage for last 14 days daily. According to the findings of our study, a decrease in SOD, CAT, GPx activity and GSH levels and an increase in MDA levels were determined in the ALZ group. In the ALZ+TQ group, while SOD, GPx, CAT activities and GSH levels increased, MDA levels decreased. Semen analyzes showed that there was a decrease in sperm motility and sperm density in the ALZ group, and an increase in the rate of abnormal sperm and dead spermatozoa. In the ALZ+TQ group, sperm motility, abnormal sperm rate and dead spermatozon rate improved. As a result, it was determined that the decrease in semen quality and increase in oxidative stress induced by AlCl3+D-Gal were suppressed by TQ, protecting the testicular tissue from oxidative damage and increasing semen quality.

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Section: Discussionmentioning

confidence: 96%

Effects of thymoquinone against D- galactose and aluminum chloride induced testicular dysfunction in rats.

AKARSU,

ÇETİN

2023

Türk Doğa Ve Fen Dergisi

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“…Imenshahidi et al demonstrated that crocins, safranal (12), and the extract of C. sativus can reduce the mean arterial pressure in both healthy and hypertensive rats depending on the dose [43].…”

Section: Antihypertensionmentioning

confidence: 99%

“…Crocins are utilized extensively as colorants and flavoring agents in the food, cosmetics, and pharmaceutical industries [ 5 ]. They exhibit a broad spectrum of pharmacological activity, including antitumor [ 6 ], anti-inflammatory [ 7 ], hepatoprotective [ 8 ], nephroprotective [ 9 ], antidepressant [ 10 ], antioxidant [ 11 ], and antidiabetic [ 12 ] properties. The Saffron Multi-glycoside Tablet (Xihonghua Zonggan Pian) ameliorates myocardial ischemia or myocardial infarction induced by coronary ligation.…”

Section: Introductionmentioning

confidence: 99%

Research progress on the pharmacological activity, biosynthetic pathways, and biosynthesis of crocins

Hua,

Liu,

Yan

2024

Beilstein J. Org. Chem.

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Crocins are water-soluble apocarotenoids isolated from the flowers of crocus and gardenia. They exhibit various pharmacological effects, including neuroprotection, anti-inflammatory properties, hepatorenal protection, and anticancer activity. They are often used as coloring and seasoning agents. Due to the limited content of crocins in plants and the high cost of chemical synthesis, the supply of crocins is insufficient to meet current demand. The biosynthetic pathways for crocins have been elucidated to date, which allows the heterologous production of these valuable compounds in microorganisms by fermentation. This review article provides a comprehensive overview of the chemistry, pharmacological activity, biosynthetic pathways, and heterologous production of crocins, aiming to lay the foundation for the large-scale production of these valuable natural products by using engineered microbial cell factories.

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Crocin Protects Mice Pancreatic Islets from Oxidative Stress Induced by Methylglyoxal and Increases Insulin Secretion

RADMEHR,

AHANGARPOUR,

HAROONI

et al. 2023

Düzce Tıp Fakültesi Dergisi

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Aim: Islets of Langerhans are more sensitive to oxidative damage because of their low antioxidant capacity. In diabetes, methylglyoxal (MG) accumulates in the pancreas. The present study examined the effect of crocin on oxidative stress induced by MG in isolated Langerhans islets from male mice. Material and Methods: Twenty-four male mice weighing 20 to 25 g were prepared. The isolated Langerhans islets were transferred to the culture medium. Oxidative stress was induced through MG administration for 30 min, and then 10, 20, 30, and 40 μM of crocin was used for 2 h. Samples were divided into seven groups with 2.8, 5.6, and 16.7 mM glucose concentrations: control, MG 300 μM, MG+glibenclamide 10 μM, and MG+crocin in four doses of 10, 20, 30, and 40 μM. At the end, the islet’s insulin, antioxidant levels, and lipid peroxidation were assessed by ELISA and calorimetry methods. Results: Increased levels of malondialdehyde (MDA) in MG groups significantly decreased in 2.8 (p=0.008), 5.6 (p=0.004), and 16.7 (p˂0.001) mM glucose concentrations, with administration of 30 and 40 μM crocin. Total antioxidant capacity (TAC) was reduced in MG groups (p˂0.001) and significantly restored in all crocin-treated groups in 2.8, 5.6, and 16.7 mM glucose concentrations. Also, a significant decrease in insulin secretion and content was observed in MG groups of all three glucose concentrations (p˂0.001). Crocin at high doses improved these alterations. Conclusion: MG caused oxidative damage and reduced insulin secretion in isolated islets. Crocin improved the antioxidant defense system, diminished MDA, and increased insulin secretion.

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D-Galaktoz ile İndüklenen Farelerde Yaşlanma Modelinin Nefropatisi Üzerine Mirisitrin ve Vitamin E’nin Koruyucu Etkileri

Cited by 3 publications

References 32 publications

Effects of thymoquinone against D- galactose and aluminum chloride induced testicular dysfunction in rats.

Effects of thymoquinone against D- galactose and aluminum chloride induced testicular dysfunction in rats.

Research progress on the pharmacological activity, biosynthetic pathways, and biosynthesis of crocins

Crocin Protects Mice Pancreatic Islets from Oxidative Stress Induced by Methylglyoxal and Increases Insulin Secretion

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