D-limonene exhibits antitumor activity by inducing autophagy and apoptosis in lung cancer

Yu, Xiao; Lin, Hongyan; Wang, Yu; Lv, Wen; Zhang, Shuo; Qian, Ying; Deng, Xiaobei; Feng, Na; Yu, Herbert; Qian, Biyun

doi:10.2147/ott.s155716

Cited by 154 publications

(106 citation statements)

References 41 publications

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“…Furthermore, its pharmaceutical activities do not confine in the mentioned components. There are several bioactive factors in Carum Carvi essential oil such as trans ‐dihydrocarvone, α‐pinene, trans ‐carveole, perillaldehyde, trans ‐β‐caryophyllene, and sabinene, which are known to have anticancer activities (Arak & Orav, , Ding & Chen, ; Pejin et al, ; Yu et al., ). In the current study, nanoemulsions of Carum Carvi essential oil were prepared to evaluate their cytotoxic and apoptotic activity of them in human HT‐29 colon cancer cells.…”

Section: Introductionmentioning

confidence: 99%

Synthesis ofCarum Carviessential oil nanoemulsion, the cytotoxic effect, and expression of caspase 3 gene

et al. 2019

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Scientists are attempting to find novel methods to overcome cancers. Nanoemulsion systems as the novel drug delivery tools have been widely used in cancer therapy. In this study, the Carum Carvi oil nanoemulsions (CCONE) were prepared and its cytotoxic activity was studied on human colon cancer HT‐29 cells using MTT assay. Flow cytometry and Real‐time qPCR were triggered to evaluate the nanoemulsions' apoptotic properties. The results showed a significant negative association between the HT‐29 cancer cell viability and CCONE doses of treatments compared with Huvec normal cells (p value < 0.001). The IC50 values were estimated 12.5 µg/ml and 50 µg/ml for HT‐29 and Huvec, respectively. Moreover, we observed that increasing concentrations of nanoemulsions significantly upregulate Caspase‐3 gene expression. The results showed the CCONE is an efficient novel apoptosis inducer for human colon cancer cells without any undesirable side effects. However, further in vitro and in vivo researches are required. Practical applications Cancer is a complex and usually untreatable disorder. Several types of cancer therapy strategies have been applied widely to overcome cancers. Chemotherapy has been used in various types of cancers. In most cases, not only it had not been effective on cancer cells but also been distractive within normal tissues. According to results, Carum Carvi essential oil nanoemulsions have apoptotic and cytotoxic effects on colon cancer cells (HT‐29). When it comes to cancer of any kind, it's important to realize that no dietary supplement can fully treat, cure, or prevent cancer. However, there are some supplements that can potentially decrease the risk of cancer. Nanoemulsions present several advantages including the ability to incorporate hydrophilic, amphiphilic, and lipophilic excipient ingredients, high physical stability, and rapid gastrointestinal digestibility. The Carum Carvi essential oil nanoemulsion can also be applied as an effective food supplement due to its potent apoptotic activity.

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Section: Introductionmentioning

confidence: 99%

Synthesis ofCarum Carviessential oil nanoemulsion, the cytotoxic effect, and expression of caspase 3 gene

et al. 2019

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“…[5][6][7][8][9] Fiber-shaped Yarn supercapacitors (YSCs) that have the merits of tiny volume, high flexibility and wearability are attractive as power sources for miniaturized electronic devices, such as micro-robots, wearable electronic textiles and implantable medical devices. [5,[15][16][17][18] These fibers have advantages of good flexibility, high specific surface area and high conductivity. [5,[15][16][17][18] These fibers have advantages of good flexibility, high specific surface area and high conductivity.…”

Section: Introductionmentioning

confidence: 99%

Twisted yarns for fiber-shaped supercapacitors based on wetspun PEDOT:PSS fibers from aqueous coagulation

et al. 2016

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+ These authors contributed equally to this work. Abstract Recently, fiber-shaped yarn supercapacitors (YSCs) have attracted extensively attention due to their merits of small volume, high flexibility and potential to be woven in the textiles for future wearable electronics. PEDOT: PSS possesses properties of high-redox capacitance, high conductivity and high intrinsic flexibility, so PEDOT: PSS yarn electrodes are quite promising in the field of YSCs. However, to the best of our knowledge, twisted yarns based on wetspun PEDOT: PSS fibers for fiber-shaped YSCs have not been reported. Herein, we develop a new coagulation bath with CaCl 2 in aqueous solution for preparing meter-long PEDOT: PSS fibers. The PEDOT: PSS fibers with good mechanical properties can be easily woven, sewed, knotted and braided as the YSCs electrode. The PEDOT: PSS fiber-based YSCs show a high areal capacitance of 119 mF cm -2 and areal energy density of 4.13 µWh cm -2 .

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“…Limonene has been shown to strongly stimulate autophagy and to prevent tumor growth in vivo as well as in vitro [114]. The treatment of limonene accelerates LC3 lipidation, which is accomplished by targeting autophagosome formation and induction of basal autophagy via activating ERK and by not inhibiting the mTOR kinase [115].…”

Section: Autophagymentioning

confidence: 99%

Therapeutic Potential of Volatile Terpenes and Terpenoids from Forests for Inflammatory Diseases

Kim

Song

Cho

et al. 2020

IJMS

174

131

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Forest trees are a major source of biogenic volatile organic compounds (BVOCs). Terpenes and terpenoids are known as the main BVOCs of forest aerosols. These compounds have been shown to display a broad range of biological activities in various human disease models, thus implying that forest aerosols containing these compounds may be related to beneficial effects of forest bathing. In this review, we surveyed studies analyzing BVOCs and selected the most abundant 23 terpenes and terpenoids emitted in forested areas of the Northern Hemisphere, which were reported to display anti-inflammatory activities. We categorized anti-inflammatory processes related to the functions of these compounds into six groups and summarized their molecular mechanisms of action. Finally, among the major 23 compounds, we examined the therapeutic potentials of 12 compounds known to be effective against respiratory inflammation, atopic dermatitis, arthritis, and neuroinflammation among various inflammatory diseases. In conclusion, the updated studies support the beneficial effects of forest aerosols and propose their potential use as chemopreventive and therapeutic agents for treating various inflammatory diseases.

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D-limonene exhibits antitumor activity by inducing autophagy and apoptosis in lung cancer

Cited by 154 publications

References 41 publications

Synthesis ofCarum Carviessential oil nanoemulsion, the cytotoxic effect, and expression of caspase 3 gene

Synthesis ofCarum Carviessential oil nanoemulsion, the cytotoxic effect, and expression of caspase 3 gene

Twisted yarns for fiber-shaped supercapacitors based on wetspun PEDOT:PSS fibers from aqueous coagulation

Therapeutic Potential of Volatile Terpenes and Terpenoids from Forests for Inflammatory Diseases

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