d-Lysergic acid diethylamide (LSD-25): A constrictor of human umbilical vein

Gant, D.W.; Dyer, Donald C.

doi:10.1016/0024-3205(71)90252-9

Cited by 17 publications

(7 citation statements)

References 7 publications

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“…Numerous drugs have been observed to constrict human umbilical blood vessels, e.g.. bradykinin [Gokhale et al, 1966;Klinge et al, 1968;Elitheringlon et al, 1968], 5-hydroxytryptamine [Somlyo et al, 1965;Astrome and Samelius, 1957;Klinge et al, 1968] and ¿-lysergic acid diethylamide [Gant and Dyer, 1971], On the other hand, recently, vasodilating agents such as sodium nitro prusside, verapamil, etc. have been used to clarify the Ca metabolism of smooth muscles other than umbilical vessels.…”

Section: Introductionmentioning

confidence: 99%

A Comparative Study of the Relaxing Effect of Nitroprusside and Verapamil on Human Umbilical Vessels

Ozaki¹,

Shibata²,

Kohno³

et al. 1981

J Vasc Res

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Relaxing effects of nitroprusside and verapamil on the resting or K-stimulated tension and ⁴⁵Ca uptake in human umbilical vessels were investigated. Both nitroprusside and verapamil reduced the resting and K-stimulated tensions in a dose-dependent manner. Nitroprusside was much more effective than verapamil in reducing resting tension. However, verapamil caused a greater relaxation of the K-induced contraction than nitroprusside. In a Ca²⁺-free medium, K⁺ still caused a small and sustained contraction. Nitroprusside abolished the contraction in the Ca²⁺-free medium, which verapamil failed to inhibit. Neither nitroprusside nor verapamil affected the resting ⁴⁵Ca uptake measured by a lanthanum method. The K-induced increase in ⁴⁵Ca uptake was inhibited by verapamil, but not by nitroprusside. The results suggest that nitroprusside unlike verapamil does not act as a Ca²⁺ influx inhibitor resulting in the relaxation of human umbilical vessels.

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Section: Introductionmentioning

confidence: 99%

A Comparative Study of the Relaxing Effect of Nitroprusside and Verapamil on Human Umbilical Vessels

Ozaki¹,

Shibata²,

Kohno³

et al. 1981

J Vasc Res

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“…drug evoked or anaphylactic reaction, it could reduce blood supply leading to growth retardation or abortion. Similarly, any drug with agonism at these receptors and which reached the fetal circulation would have similar consequences, as has been postulated previously for LSD (D-lysergic acid diethylamide; Gant & Dyer, 1971).…”

mentioning

confidence: 60%

Comparison of the Effects of Oxygen, 5‐hydroxytryptamine, Bradykinin and Adrenaline in Isolated Human Umbilical Artery Smooth Muscle

McGrath

MacLennan²,

Whittle

1988

Exp Physiol

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SUMMARYThe actions of 5-HT, bradykinin and adrenaline on the isolated human umbilical artery (HUA) were examined in paired isometric and isotonic preparations and in paired isometric and perfused preparations at both low ( 20 mmHg) and high (-120 mmHg) oxygen tensions. The response to each agonist was potentiated by the higher oxygen tension in all test systems. The relative potency of the three agonists studied was similar using each of the experimental techniques. The contractions to stepped increments in oxygen tension were compared in isometric and isotonic preparations. The thresholds were found to be 20 and 28 mmHg respectively. The maximum contraction occurred at 234 and 199 mmHg respectively. In the perfused (constant flow rate) preparations, oxygen did not evoke any increase in perfusion pressure unless the vessel was held under longitudinal tension, in which case the pressor responses were similarly concentration dependent as for isometric and isotonic preparations. Responses to 5-HT, bradykinin and adrenaline in the perfused preparation were similar with or without application of longitudinal tension. It is concluded that oxygen may contract only the longitudinal muscle whereas 5-HT, bradykinin and adrenaline act on both longitudinal and circular muscle. The possible roles which these agonists may play in the regulation of umbilical blood flow are discussed.

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“…Strips of human umbilical vessels were prepared as previously described [7]. Sheep umbilical vasculature was obtained and prepared as previously described [4].…”

Section: Methodsmentioning

confidence: 99%

“…The fetus was delivered aseptically by cesarean section. The umbilical cord was tied on both fetal and placental ends, cut between the ties and placed in a modified Krebs-Henseleit (Krebs) solution previously described [7]. The umbilical vein was dissected free of tissue and cut helically into strips about 2 mm wide and 3 cm long.…”

Section: Methodsmentioning

confidence: 99%

“…All agonists were administered in a cumulative manner by micropipettes. Serotonin, which in our previous studies on umbilical vasculature was always found to be a good agonist [4,7] was routinely used in this study to establish maximal contractility on all vascular strips. The following drugs were used in this study: serotonin creatinine sulfate, histamine diphosphate and tripelennamine hydro chloride.…”

Section: Methodsmentioning

confidence: 99%

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Actions of Histamine on Human, Sheep and Monkey Umbilical Vasculature

Dyer¹,

Gant²,

Park³

1972

Pharmacology

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Comparative studies on the actions of serotonin and histamine were carried out on umbilical arteries and veins from humans and sheep and on monkey umbilical veins. All vein preparations and human umbilical arteries were more sensitive to serotonin than to histamine. Tripelen-namine specifically antagonized responses to histamine. Only on monkey umbilical vein strips did histamine produce a greater than serotonin-evoked maximal contraction. These studies suggest that the vasoconstrictor action of histamine has the potential of influencing the umbilical vasculature in vivo.

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d-Lysergic acid diethylamide (LSD-25): A constrictor of human umbilical vein

Cited by 17 publications

References 7 publications

A Comparative Study of the Relaxing Effect of Nitroprusside and Verapamil on Human Umbilical Vessels

A Comparative Study of the Relaxing Effect of Nitroprusside and Verapamil on Human Umbilical Vessels

Comparison of the Effects of Oxygen, 5‐hydroxytryptamine, Bradykinin and Adrenaline in Isolated Human Umbilical Artery Smooth Muscle

Actions of Histamine on Human, Sheep and Monkey Umbilical Vasculature

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