d-methionine (d-met) significantly rescues noise-induced hearing loss: Timing studies

Campbell, Kathleen C.M.; Claussen, Alexander D.; Meech, Robert P.; Verhulst, Steven J.; Fox, Daniel J.; Hughes, Larry F.

doi:10.1016/j.heares.2011.08.003

Cited by 63 publications

(33 citation statements)

References 44 publications

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“…Pre-clinical studies have shown benefit for several molecules that can be obtained from normal healthy diets; some of these agents include beta-carotene, vitamins C and E, and magnesium (Le Prell et al, 2007a; Tamir et al, 2010; Le Prell et al, 2011a; Le Prell et al, 2011b), D-methionine (Campbell et al, 2007; Campbell et al, 2011; Clifford et al, 2011; Claussen et al, 2013; Lo et al, 2013; Rewerska et al, 2013), and N-acetylcysteine (Kopke et al, 2000; Kopke et al, 2005; Bielefeld et al, 2007; Kopke et al, 2007; Clifford et al, 2011). Ultimately, it may indeed be possible to prevent the secondary “spread” of damage that occurs with continued metabolic stress after noise stress.…”

Section: Discussionmentioning

confidence: 99%

Associations between dietary quality, noise, and hearing: Data from the National Health and Nutrition Examination Survey, 1999–2002

Spankovich

Prell

2014

International Journal of Audiology

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Section: Discussionmentioning

confidence: 99%

Associations between dietary quality, noise, and hearing: Data from the National Health and Nutrition Examination Survey, 1999–2002

Spankovich

Prell

2014

International Journal of Audiology

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“…The action of antioxidants is attracting most attention, with D-methionine or a combination of betacarotene, vitamin C, vitamin E, and magnesium showing initial promise. 104,105 Repair of cochlear damage by use of gene therapy and stem cell therapy is also being studied. 103 …”

Section: Preventionmentioning

confidence: 99%

Tinnitus

Baguley¹,

McFerran²,

Hall³

2013

The Lancet

1,063

911

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Tinnitus is a common medical symptom that can be debilitating. Risk factors include hearing loss, ototoxic medication, head injury, and depression. At presentation, the possibilities of otological disease, anxiety, and depression should be considered. No eff ective drug treatments are available, although much research is underway into mechanisms and possible treatments. Surgical intervention for any otological pathology associated with tinnitus might be eff ective for that condition, but the tinnitus can persist. Available treatments include hearing aids when hearing loss is identifi ed (even mild or unilateral), wide-band sound therapy, and counselling. Cognitive behavioural therapy (CBT) is indicated for some patients, but availability of tinnitus-specifi c CBT in the UK is poor. The evidence base is strongest for a combination of sound therapy and CBT-based counselling, although clinical trials are constrained by the heterogeneity of patients with tinnitus.

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“…Administration of D-methionine after noise exposure leads to rescue from noise induced auditory brain stem response threshold shift [16]. Dleucine has potential anti-seizure properties.…”

Section: Methodsmentioning

confidence: 99%

Combinatorial Effect of D-Aminoacids and Tetracycline Against Pseudomonas Aeruginosa Biofilm

Jayalekshmi

Harikrishnan

Sali

et al. 2016

Int J Pharm Pharm Sci

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Objective: The present study attempted to evaluate the anti-biofilm activity of D-amino acids (D-AAs) on Pseudomonas aeruginosa and determine if the combination of D-AAs with tetracycline enhances the anti-biofilm activity in vitro and ex vivo. Methods:Different D-AAs were tested for antibiofilm activity against wild type P. aeruginosa PAO1 and two multidrug resistant P. aeruginosa clinical strains in the presence of sub inhibitory concentrations of tetracycline using crystal violet microtitre plate assay. Results were further validated using in vitro wound dressing and ex vivo porcine skin models followed by cytotoxicity and hemocompatibility studies.Results: D-tryptophan (5 mmol) showed 61 % reduction in biofilm formation of P. aeruginosa. Interestingly combinatorial effect of 5 mmol Dtryptophan and 0.5 minimum inhibitory concentration (MIC) (7.5µg/ml) tetracycline showed 90% reduction in biofilm formation. 5 mmol Dmethionine shows 28 % reduction and combination with tetracycline shows 41% reduction in biofilm formation of P. aeruginosa. D-leucine and Dtyrosine alone or in combination with tetracycline did not show significant anti-biofilm activity. D tryptophan-tetracycline combination could reduce 80 % and 77 % reduction in biofilm formation in two multi drug resistant P. aeruginosa clinical strains. D-tryptophan-tetracyclinecombination could also reduce 76% and 66% reduction in biofilm formation in wound dressing model and porcine skin explant respectively. The cytotoxicity and hemocompatibility studies did not show significant toxicity when this combination was used. Conclusion:The results established the potential therapeutic application of D-tryptophan alone or in combination with tetracycline for treating biofilm associated clinical problems caused by P. aeruginosa.

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d-methionine (d-met) significantly rescues noise-induced hearing loss: Timing studies

Cited by 63 publications

References 44 publications

Associations between dietary quality, noise, and hearing: Data from the National Health and Nutrition Examination Survey, 1999–2002

Associations between dietary quality, noise, and hearing: Data from the National Health and Nutrition Examination Survey, 1999–2002

Tinnitus

Combinatorial Effect of D-Aminoacids and Tetracycline Against Pseudomonas Aeruginosa Biofilm

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