D-penicillamine-induced myositis in rheumatoid arthritis

Chappel, R

doi:10.1007/bf02231694

Cited by 14 publications

(4 citation statements)

References 5 publications

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“…Besides autoimmune myasthenia gravis, approximately 0.2-1.4% of patients treated with D-penicillamine developed an inflammatory myopathy reminiscent of polymyositis or dermatomyositis (76,77). Discontinuation of the drug results in resolution of the symptoms.…”

Section: Drug Induced Inflammatory Myopathiesmentioning

confidence: 99%

Toxic Myopathies

2014

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Muscle tissue is highly sensitive to many substances. Early recognition of toxic myopathies is important, as they potentially are reversible on removal of the offending drug or toxin, with greater likelihood of complete resolution the sooner this is achieved. Clinical features range from mild muscle pain and cramps to severe weakness with rhabdomyolysis, renal failure, and even death. The pathogenic bases can be multifactorial. This article reviews some of the common toxic myopathies and their clinical presentation, histopathologic features and possible underlying cellular mechanisms.

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Section: Drug Induced Inflammatory Myopathiesmentioning

confidence: 99%

Toxic Myopathies

2014

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“…Myositis can be induced by D ‐penicillamine at any time in the course of treatment, even with low doses. Recovery occurs after withdrawal of D ‐penicillamine, although several cases have required corticosteroid therapy to induce remission 23. Associated myocardial involvement, potentially fatal, has been observed 12…”

Section: Inflammatory Myopathiesmentioning

confidence: 99%

Iatrogenic and toxic myopathies

Sieb

Gillessen

2002

Muscle and Nerve

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There has been increasing awareness of the adverse effects of therapeutic agents and exogenous toxins on the structure and function of muscle. The resulting clinical syndrome varies from one characterized by muscle pain to profound myalgia, paralysis, and myoglobinuria. Because toxic myopathies are potentially reversible, their prompt recognition may reduce their damaging effects or prevent a fatal outcome. Interest in the toxic myopathies, however, derives not only from their clinical importance but also from the fact that they serve as useful experimental models in muscle research. Morphological and biochemical studies have increased our understanding of the basic cellular mechanisms of myotoxicity. Toxins may produce, for instance, necrotizing, lysosomal-related, inflammatory, anti-microtubular, mitochondrial, hypokalemia-related, or protein synthesis-related muscle damage.

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“…37 Similarly, procainamide can be associated with myalgias, weakness, CK elevations, and an inflammatory muscle biopsy. 37 Similarly, procainamide can be associated with myalgias, weakness, CK elevations, and an inflammatory muscle biopsy.…”

Section: Inflammatory Drug-induced Myopathiesmentioning

confidence: 99%